Shawn E Davis

US Patent:

20220313128, Oct 6, 2022

Filed:

Jan 13, 2022

Appl. No.:

17/575493

Inventors:

- Medford MA, US
Shawn Davis - Santa Monica CA, US
Ping Gong - Belmont MA, US
Kristin Horton - Brighton MA, US
Scott James - Epping NH, US

Assignee:

YourBio Health, Inc. - Medford MA

International Classification:

A61B 5/15
A61M 1/34
A61M 1/36
A61B 5/145
A61B 5/151
A61B 5/154
B01L 3/00
G01N 33/18

Abstract:

The present invention generally relates to systems and methods for receiving blood (or other bodily fluids) from a subject, e.g., from or beneath the skin of a subject. In some cases, the blood (or other bodily fluids) may be deposited on a membrane or other substrate. For example, blood may be absorbed in a substrate, and dried in some cases to produce a dried blood spot. In one aspect, the present invention is generally directed to devices and methods for receiving blood from a subject, e.g., from the skin, using devices including a substance transfer component (which may contain, for example, one or more microneedles), and directing the blood on a substrate, e.g., for absorbing blood. The substrate, in some embodiments, may comprise filter paper or cotton-based paper. After absorption of some blood onto the substrate, the substrate may be removed from the device and shipped or analyzed. In some cases, the device itself may be shipped or analyzed. For example, in some embodiments, a portion of the device may be sealed such that the substrate is contained within an airtight portion of the device, optionally containing desiccant. Other aspects are generally directed at other devices for receiving blood (or other bodily fluids), kits involving such devices, methods of making such devices, methods of using such devices, and the like.

US Patent:

20220287642, Sep 15, 2022

Filed:

Dec 21, 2021

Appl. No.:

17/557191

Inventors:

- Medford MA, US
Shawn Davis - Santa Monica CA, US
Ramin Haghgooie - Arlington MA, US
Howard Bernstein - Cambridge MA, US
Douglas A. Levinson - Sherborn MA, US
Mark Michelman - Reading MA, US

Assignee:

YourBio Health, Inc. - Medford MA

International Classification:

A61B 5/00
A61B 5/15
A61B 5/151
A61B 5/157
A61B 5/145

Abstract:

The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.

US Patent:

20220257158, Aug 18, 2022

Filed:

Dec 3, 2021

Appl. No.:

17/541548

Inventors:

- Medford MA, US
Shawn Davis - Santa Monica CA, US
Mark Michelman - Reading MA, US
Howard Bernstein - Cambridge MA, US
Kristin Horton - Brighton MA, US

Assignee:

YourBio Health, Inc. - Medford MA

International Classification:

A61B 5/15
A61M 1/34
A61M 1/36
A61B 5/145
A61B 5/151
A61B 5/154
B01L 3/00
G01N 33/18

Abstract:

In some embodiments, the present invention generally relates to the separation of blood within a device to form plasma or serum. In some embodiments, the present invention generally relates to the removal of fluids, such as blood, contained within a device. In one aspect, the present invention is generally directed to systems and methods for receiving blood from a subject and processing the blood to form plasma or serum. For example, a device may be applied to the skin of a subject to receive blood from the subject and pass the blood through a separation membrane, which separates the blood into plasma and a portion concentrated in blood cells. As another example, blood or plasma may be allowed to clot within the device and serum (the unclotted portion of the blood) may be withdrawn from the device. The device may contain, in some cases, a vacuum source such as a pre-packaged vacuum to facilitate receiving of blood and/or passage of the blood through the separation membrane to produce plasma or serum. In certain embodiments, plasma, serum, or other fluids may be removed from the device by inserting a needle into a portion of the device that has reduced pressure, expelling gas into the device through the needle, then receiving plasma, serum, or other fluids through the needle.

US Patent:

20210259599, Aug 26, 2021

Filed:

Oct 7, 2020

Appl. No.:

17/064618

Inventors:

- Medford MA, US
Shawn Davis - Santa Monica CA, US
Mark Michelman - Reading MA, US
Li Yang Chu - Medford MA, US

Assignee:

Seventh Sense Biosystems, Inc. - Medford MA

International Classification:

A61B 5/15
A61B 5/151
A61B 5/145
A61B 10/00
A61M 37/00

Abstract:

Systems and methods for delivering to and/or receiving fluids or other materials, such as blood or interstitial fluid, from subjects, e.g., from the skin. Beading disruptors and/or capillaries may be used for facilitating the transport of fluids from a subject into a device. Beading disruptors may disrupt the “pooling” of bodily fluids such as blood on the surface of the skin and help influence flow in a desired way. A capillary may conduct flow of fluid in the device, e.g., to an inlet of a channel or other flow path that leads to a storage chamber. A vacuum (reduced pressure relative to ambient) may be used to receive fluid into the device, e.g., by using relatively low pressure to draw fluid into the inlet of a channel leading to a storage chamber. The vacuum source may be part of the device and have a volume that is larger than a recess of the fluid transporter that receives fluid from a surface.

US Patent:

20210022681, Jan 28, 2021

Filed:

Mar 2, 2020

Appl. No.:

16/806426

Inventors:

- Medford MA, US
Shawn Davis - Santa Monica CA, US
Ramin Haghgooie - Arlington MA, US
Howard Bernstein - Cambridge MA, US
Douglas A. Levinson - Sherborn MA, US

Assignee:

Seventh Sense Biosystems, Inc. - Medford MA

International Classification:

A61B 5/00
A61B 5/15
A61B 5/151
A61B 5/157
A61B 5/145

Abstract:

The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, in some cases, may be interfaced with external equipment to determine an analyte contained within a fluid contained within or collected by the device. For example, the device may be mounted or engaged on an external holder, the device may include a port for transporting fluid out of the device, the device may include a window for interrogating a fluid contained within the device, or the like. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.

US Patent:

20200015751, Jan 16, 2020

Filed:

Dec 1, 2017

Appl. No.:

15/828908

Inventors:

- Medford MA, US
Shawn Davis - Santa Monica CA, US
Ramin Haghgooie - Arlington MA, US
Howard Bernstein - Cambridge MA, US
Douglas A. Levinson - Sherborn MA, US
Mark Michelman - Reading MA, US

Assignee:

Seventh Sense Biosystems, Inc. - Medford MA

International Classification:

A61B 5/00
A61B 5/15
A61B 5/145
A61B 5/151
A61B 5/157

Abstract:

The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.

US Patent:

20190336058, Nov 7, 2019

Filed:

Dec 12, 2018

Appl. No.:

16/218441

Inventors:

- Medford MA, US
Shawn Davis - Santa Monica CA, US
Mark Michelman - Reading MA, US
Howard Bernstein - Cambridge MA, US
Kristin Horton - Brighton MA, US

Assignee:

Seventh Sense Biosystems, Inc. - Medford MA

International Classification:

A61B 5/15
A61M 1/36
G01N 33/18
A61B 5/145
A61M 1/34
B01L 3/00
A61B 5/154
A61B 5/151

Abstract:

In some embodiments, the present invention generally relates to the separation of blood within a device to form plasma or serum. In some embodiments, the present invention generally relates to the removal of fluids, such as blood, contained within a device. In one aspect, the present invention is generally directed to systems and methods for receiving blood from a subject and processing the blood to form plasma or serum. For example, a device may be applied to the skin of a subject to receive blood from the subject and pass the blood through a separation membrane, which separates the blood into plasma and a portion concentrated in blood cells. As another example, blood or plasma may be allowed to clot within the device and serum (the unclotted portion of the blood) may be withdrawn from the device. The device may contain, in some cases, a vacuum source such as a pre-packaged vacuum to facilitate receiving of blood and/or passage of the blood through the separation membrane to produce plasma or serum. In certain embodiments, plasma, serum, or other fluids may be removed from the device by inserting a needle into a portion of the device that has reduced pressure, expelling gas into the device through the needle, then receiving plasma, serum, or other fluids through the needle.

US Patent:

20180242890, Aug 30, 2018

Filed:

Sep 1, 2017

Appl. No.:

15/693666

Inventors:

- Medford MA, US
Shawn Davis - Santa Monica CA, US
Ramin Haghgooie - Arlington MA, US
Howard Bernstein - Cambridge MA, US
Douglas A. Levinson - Sherborn MA, US

Assignee:

Seventh Sense Biosystems, Inc. - Medford MA

International Classification:

A61B 5/145
A61B 5/15
A61B 5/151
A61B 5/00
A61B 5/157

Abstract:

The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, in some cases, may be interfaced with external equipment to determine an analyte contained within a fluid contained within or collected by the device. For example, the device may be mounted or engaged on an external holder, the device may include a port for transporting fluid out of the device, the device may include a window for interrogating a fluid contained within the device, or the like. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.