Shawn E Green

US Patent:

6773669, Aug 10, 2004

Filed:

Nov 8, 2000

Appl. No.:

09/707928

Inventors:

John W. Holaday - Bethesda MD
Peter H. Meserol - Montville NJ
Doug Doerfler - Darnestown MD
Shawn J. Green - Vienna VA
Vininder Singh - Gaithersburg MD

Assignee:

Maxcyte, Inc. - Rockville MD

International Classification:

C12N 1587

US Classification:

422 44, 422 33, 4351736

Abstract:

The present invention relates to a method and apparatus for the encapsulation of substances and drugs into cells and platelets. The present invention is also related to the incorporation of thrombus dissolving drugs, such as tissue plasminogen activator and streptokinase into platelets using the apparatus described herein. The treated platelets can then be used to treat patients suffering from a thrombus blocking a blood vessel. The present invention is also related to a preparation of red blood cells that has a stable right shift of the oxygen dissociation curve.

US Patent:

20050019311, Jan 27, 2005

Filed:

May 14, 2004

Appl. No.:

10/846729

Inventors:

John Holaday - Bethesda MD, US
Peter Meserol - Montville NJ, US
Doug Doerfler - Darnestown MD, US
Shawn Green - Vienna VA, US
Vininder Singh - Gaithersburg MD, US

International Classification:

A61K045/00
C12N005/08

US Classification:

424093700, 435372000

Abstract:

The present invention relates to a method and apparatus for the encapsulation of substances and drugs into cells and platelets. The present invention is also related to the incorporation of thrombus dissolving drugs, such as tissue plasminogen activator and streptokinase into platelets using the apparatus described herein. The treated platelets can then be used to treat patients suffering from a thrombus blocking a blood vessel. The present invention is also related to a preparation of red blood cells that has a stable right shift of the oxygen dissociation curve.

US Patent:

20200352986, Nov 12, 2020

Filed:

Jul 22, 2020

Appl. No.:

16/936036

Inventors:

Shawn J. Green - Bethesda MD, US

International Classification:

A61K 33/00
A61K 31/375
A61P 31/14

Abstract:

Compositions, methods of manufacturing compositions, methods of protecting against respiratory problems including coronavirus and coronavirus-associated severe acute respiratory syndrome (SARS) in humans and animals, are provided. Compositions comprising inorganic nitrate used for improving nitric oxide levels, improving health and/or reducing symptoms of SARS are provided. The compositions and methods are applicable for subjects experiencing SARS, and for protecting non-infected subjects against SARS. Compositions and methods for improving nitric oxide levels in a subject disclosed herein comprise administration of compositions comprising inorganic nitrate such as potassium nitrate or sodium nitrate optionally combined with ascorbate.