Shawn S Green

US Patent:

6946439, Sep 20, 2005

Filed:

Feb 28, 2002

Appl. No.:

10/086176

Inventors:

Todd Hembrough - Damascus MD, US
Victor P. Pribluda - Silver Spring MD, US
Shawn J. Green - Vienna VA, US

Assignee:

Entre Med, Inc. - Rockville MD

International Classification:

A61K038/16

US Classification:

514 2, 514 12, 514 13

Abstract:

Compositions and methods effective in inhibiting abnormal or undesirable cell proliferation, particularly endothelial cell proliferation and angiogenesis related to neovascularization and tumor growth are provided. The compositions comprise a naturally occurring or synthetic protein, peptide, or protein fragment containing all or an active portion of the C-terminal portion of proteinase inhibitors such as TFPI. The methods involve administering to a human or animal the composition described herein in a dosage sufficient to inhibit cell proliferation, particularly endothelial cell proliferation. The methods are useful for treating diseases and processes mediated by undesired and uncontrolled cell proliferation, such as cancer, particularly by inhibiting angiogenesis. Administration of the composition to a human or animal having prevascularized, metastasized tumors is useful for preventing the growth or expansion of such tumors.

US Patent:

20020098176, Jul 25, 2002

Filed:

Jul 12, 2001

Appl. No.:

09/905033

Inventors:

Todd Hembrough - Damascus MD, US
Shawn Green - Vienna VA, US

International Classification:

A61K038/48
C12N009/64

US Classification:

424/094630, 435/226000

Abstract:

The present invention relates to compositions and uses of nematode anticoagulant proteins (NAPs). More specifically, the invention relates to the use of rNAPc2 and rNAP5 for the inhibition of endothelial cell proliferation and the inhibition of angiogenesis. The invention also relates to methods for the treatment of angiogenesis-mediated diseases, such as cancer.

US Patent:

20060025329, Feb 2, 2006

Filed:

Jul 18, 2005

Appl. No.:

11/183555

Inventors:

Todd Hembrough - Damascus MD, US
Victor Pribluda - Silver Spring MD, US
Shawn Green - Vienna VA, US

International Classification:

A61K 38/17

US Classification:

514002000

Abstract:

Compositions and methods effective in inhibiting abnormal or undesirable cell proliferation, particularly endothelial cell proliferation and angiogenesis related to neovascularization and tumor growth are provided. The compositions comprise a naturally occurring or synthetic protein, peptide, or protein fragment containing all or an active portion of the C-terminal portion of proteinase inhibitors such as TFPI. The methods involve administering to a human or animal the composition described herein in a dosage sufficient to inhibit cell proliferation, particularly endothelial cell proliferation. The methods are useful for treating diseases and processes mediated by undesired and uncontrolled cell proliferation, such as cancer, particularly by inhibiting angiogenesis. Administration of the composition to a human or animal having prevascularized, metastasized tumors is useful for preventing the growth or expansion of such tumors.