Shawn Lyons

US Patent:

6379703, Apr 30, 2002

Filed:

Nov 28, 2000

Appl. No.:

09/722335

Inventors:

Shawn L. Lyons - Cincinnati OH
J. Michael Ramstack - Lebanon OH
Steven G. Wright - Madeira OH

Assignee:

Alkermes Controlled Therapeutics Inc., II - Cambridge MA

International Classification:

A61K 914

US Classification:

424489, 264 41, 264 421, 264115, 264117, 264122, 5147723

Abstract:

An improved method for preparing microparticles that exhibit controlled release of an effective amount of an active agent over an extended period of time. More particularly, a method is provided for preparing microparticles having a selected release profile for release of active agent contained in the microparticles. By adjusting the degree of drying that is performed during the preparation of the microparticles, the release profile can be controlled. By performing no intermediate drying, an initial burst and a substantially linear release profile is achieved. By performing substantially complete intermediate drying, an initial lag phase and a substantially sigmoidal release profile is achieved.

US Patent:

6379704, Apr 30, 2002

Filed:

Jun 1, 2001

Appl. No.:

09/870751

Inventors:

Steven G. Wright - Madeira OH
Michael E. Rickey - Loveland OH
J. Michael Ramstack - Lebanon OH
Shawn L. Lyons - Cincinnati OH
Joyce M. Hotz - Cincinnati OH

Assignee:

Alkermes Controlled Therapeutics Inc. II - Cambridge MA

International Classification:

A61K 914

US Classification:

424489, 424497, 424484, 264 41, 264 46, 4272133, 42721336

Abstract:

A method for preparing microparticles having a selected polymer molecular weight. The hold time and temperature of a solution containing a nucleophilic compound and a polymer having a starting molecular weight are controlled in order to control the molecular weight of the polymer in the finished microparticle product. In this manner, a selected polymer molecular weight in the finished microparticle product can be achieved from a variety of starting material molecular weights.

US Patent:

6395304, May 28, 2002

Filed:

Apr 10, 2001

Appl. No.:

09/828849

Inventors:

Shawn L. Lyons - Cincinnati OH
Steven G. Wright - Madeira OH

Assignee:

Alkermes Controlled Therapeutics Inc. II - Cambridge MA

International Classification:

A61K 950

US Classification:

424501, 424 129, 424489, 424490, 264 41, 264 433, 264 46, 42840221, 4272133, 42721336

Abstract:

Apparatus and method for preparing microparticles. An emulsion is formed by combining two phases in a static mixing assembly. The static mixing assembly preferably includes a preblending static mixer and a manifold. The emulsion flows out of the static mixing assembly into a quench liquid whereby droplets of the emulsion form microparticles. The residence time of the emulsion in the static mixing assembly is controlled to obtain a predetermined particle size distribution of the resulting microparticles.

US Patent:

6495166, Dec 17, 2002

Filed:

Nov 12, 1999

Appl. No.:

09/438656

Inventors:

Shawn L. Lyons - Cincinnati OH
Steven G. Wright - Madeira OH

Assignee:

Alkermes Controlled Therapeutics Inc. - Cambridge MA

International Classification:

A61K 950

US Classification:

424490, 42840224

Abstract:

Apparatus and method for preparing microparticles using in-line solvent extraction. An emulsion is formed by combining two phases in a static mixer. The emulsion is combined with an extraction liquid in a blending static mixer. The outflow of the blending static mixer is combined with additional extraction liquid. The additional extraction liquid and the outflow of the blending static mixer can be combined in a vessel, or through the use of a static mixer manifold that includes a plurality of static mixers.

US Patent:

6534092, Mar 18, 2003

Filed:

Feb 14, 2002

Appl. No.:

10/073864

Inventors:

Steven G. Wright - Madeira OH
Michael E. Rickey - Loveland OH
J. Michael Ramstack - Lebanon OH
Shawn L. Lyons - Cincinnati OH
Joyce M. Hotz - Cincinnati OH

Assignee:

Alkermes Controlled Therapeutics, Inc. II - Cambridge MA

International Classification:

A61K 914

US Classification:

424489, 424484, 424497, 264 41, 264 46, 427 203, 42721336

Abstract:

A method for preparing microparticles having a selected polymer molecular weight. The hold time and temperature of a solution containing a nucleophilic compound and a polymer having a starting molecular weight are controlled in order to control the molecular weight of the polymer in the finished microparticle product. In this manner a selected polymer molecular weight in the finished microparticle product can be achieved from a variety of starting material molecular weights.

US Patent:

6537586, Mar 25, 2003

Filed:

Apr 1, 2002

Appl. No.:

10/109641

Inventors:

Shawn L. Lyons - Cincinnati OH
Steven G. Wright - Madeira OH

Assignee:

Alkermes Controlled Therapeutics Inc. II - Cambridge MA

International Classification:

A61K 950

US Classification:

424501, 424 129, 424489, 424490, 424497, 264 41, 264 433, 264 46, 42840221, 4272133, 42721336

Abstract:

Apparatus and method for preparing microparticles. An emulsion is formed by combining two phases in a static mixing assembly. The static mixing assembly preferably includes a preblending static mixer and a manifold. The emulsion flows out of the static mixing assembly into a quench liquid whereby droplets of the emulsion form microparticles. The residence time of the emulsion in the static mixing assembly is controlled to obtain a predetermined particle size distribution of the resulting microparticles.

US Patent:

6540393, Apr 1, 2003

Filed:

Aug 16, 2001

Appl. No.:

09/930450

Inventors:

Shawn L. Lyons - Cincinnati OH
Steven G. Wright - Madeira OH

Assignee:

Alkermes Controlled Therapeutics Inc. II - Cambridge MA

International Classification:

B01F 1502

US Classification:

3661815, 366336, 366348

Abstract:

Apparatus and method for preparing microparticles using in-line solvent extraction. An emulsion is formed by combining two phases in a static mixer. The emulsion is combined with an extraction liquid in a blending static mixer. The outflow of the blending static mixer is combined with additional extraction liquid. The additional extraction liquid and the outflow of the blending static mixer can be combined in a vessel, or through the use of a static mixer manifold that includes a plurality of static mixers.

US Patent:

6596316, Jul 22, 2003

Filed:

Jan 31, 2002

Appl. No.:

10/059115

Inventors:

Shawn L. Lyons - Cincinnati OH
J. Michael Ramstack - Lebanon OH
Steven G. Wright - Madeira OH

Assignee:

Alkermes Controlled Therapeutics, Inc. II - Cambridge MA

International Classification:

A61K 914

US Classification:

424489

Abstract:

An improved method for preparing microparticles that exhibit controlled release of an effective amount of an active agent over an extended period of time. More particularly, a method is provided for preparing microparticles having a selected release profile for release of active agent contained in the microparticles. By adjusting the degree of drying that is performed during the preparation of the microparticles, the release profile can be controlled. By performing no intermediate drying, an initial burst and a substantially linear release profile is achieved. By performing substantially complete intermediate drying, an initial lag phase and a substantially sigmoidal release profile is achieved.