Shiazah Z Malik

US Patent:

20040146973, Jul 29, 2004

Filed:

Nov 6, 2003

Appl. No.:

10/704332

Inventors:

Anja Kammesheidt - Laguna Beach CA, US
Shiazah Malik - Santa Ana CA, US

Assignee:

Euro-Celtique S.A. - Luxembourg

International Classification:

C07K014/705
C07H021/04

US Classification:

435/069100, 435/320100, 435/325000, 530/350000, 536/023500

Abstract:

The present invention provides nucleic acids encoding a novel protein subunit of a human proton-gated acid-sensing ion channel, designated hASIC2b. The present invention also provides the amino acid sequence of the novel hASIC2b, genetically engineered host cells expressing hASIC2b nucleic acids and amino acids, as well as methods for identifying modulators of hASIC2b-containing ion channels.

US Patent:

20190185523, Jun 20, 2019

Filed:

Dec 20, 2018

Appl. No.:

16/227027

Inventors:

- Irvine CA, US
Amy Brideau-Andersen - San Clemente CA, US
Hui You - Irvine CA, US
Shiazah Z. Malik - Irvine CA, US
Donald E. Frail - Laguna Hills CA, US
Mitchell F. Brin - Newport Beach CA, US

International Classification:

C07K 14/33
C12N 9/52
C07K 14/315
A61Q 19/00
A61Q 19/08
A61P 17/06
A61P 17/10
A61P 17/08
A61P 37/00
A61P 29/00

Abstract:

A polypeptide having an amino acid sequence corresponding to a binding domain of a botulinum toxin is described. The polypeptide modulates expression of genes involved in, for example, collagen production and extra cellular matrix organization, and finds use, therefore in modulating skin quality attributes such as elasticity, firmness etc. Moreover, the polypeptide inhibits lipogenesis in specialized cells and finds use, therefore, in reducing skin oiliness, which is frequently observed in skin tissue afflicted with large pores and acne. Nucleic acids encoding the polypeptide, as well as vectors, host cells, and systems comprising the nucleic acids, are further described.