Shigeo Matsuda

age ~51

from Andover, MA

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Shigeo Matsuda Phones & Addresses

  • 123 Jenkins Rd, Andover, MA 01810 • 9784704595
  • Woburn, MA
  • Cambridge, MA
  • San Diego, CA
  • Oceanside, CA
  • 7106 Inwood Dr, Woburn, MA 01801

Us Patents

  • Chemical Modifications Of Monomers And Oligonucleotides With Cycloaddition

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  • US Patent:
    20120035115, Feb 9, 2012
  • Filed:
    Sep 23, 2009
  • Appl. No.:
    13/120389
  • Inventors:
    Muthiah Manoharan - Cambridge MA, US
    Takeshi Yamada - Cambridge MA, US
    David Butler - Cambridge MA, US
    K. Narayanannair Jayaprakash - Cambridge MA, US
    Muthusamy Jayraman - Cambridge MA, US
    Shigeo Matsuda - Cambridge MA, US
    Rajendra K. Pandey - Cambridge MA, US
    Chang Geng Peng - Cambridge MA, US
  • Assignee:
    ALNYLAM PHARMACEUTICALS, INC. - Cambridge MA
  • International Classification:
    A61K 38/14
    C07H 19/10
    C07F 9/6561
    C07H 21/02
    A61K 31/7072
    A61K 31/675
    C07H 1/00
    A61P 31/12
    A61P 31/04
    A61P 33/00
    A61P 35/00
    A61P 37/08
    A61P 37/06
    A61P 37/04
    C07K 9/00
    A61K 31/7088
  • US Classification:
    514 209, 514 44 A, 536 268, 544244, 536 231, 536 245, 536 171, 514 32, 514 51, 514 81, 536 253, 514 44 R, 530322
  • Abstract:
    The invention features compounds of formula I or II:In one embodiment, the invention relates compounds and processes for conjugating ligand to oligonucleotide. The invention further relates to methods for treating various disorders and diseases such as viral infections, bacterial infections, parasitic infections, cancers, allergies, autoimmune diseases, immunodeficiencies and immunosuppression.

  • Nucleic Acid Chemical Modifications

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  • US Patent:
    20120071641, Mar 22, 2012
  • Filed:
    Mar 2, 2010
  • Appl. No.:
    13/203927
  • Inventors:
    Muthiah Manoharan - Cambridge MA, US
    Alexander V. Kelin - Cambridge MA, US
    Sudhakar Rao Takkellapati - Cambridge MA, US
    Shigeo Matsuda - Cambridge MA, US
  • Assignee:
    ALNYLAM PHARMACEUTICALS, INC. - Cambridge MA
  • International Classification:
    C07H 21/02
    C07H 19/167
    C07H 19/10
    C07H 19/067
    C07H 21/00
    C07H 19/20
  • US Classification:
    536 245, 536 231, 536 267, 536 268, 536 285, 536 2853, 536 2762, 536 2781, 536 2854
  • Abstract:
    The present invention provides nucleosides of formula (1) and oligonucleotides comprising at least one nucleoside of formula (2): Another aspect of the invention relates to a method of inhibiting the expression of a gene in cell, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.

  • Biodegradable Lipids For The Delivery Of Active Agents

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  • US Patent:
    20130195920, Aug 1, 2013
  • Filed:
    Dec 7, 2012
  • Appl. No.:
    13/708383
  • Inventors:
    Muthusamy Jayaraman - Cambridge MA, US
    Akin Akinc - Cambridge MA, US
    Shigeo Matsuda - Cambridge MA, US
    Pachamuthu Kandasamy - Malden MA, US
    Muthiah Manoharan - Cambridge MA, US
  • Assignee:
    ALNYLAM PHARMACEUTICALS, INC. - Cambridge MA
  • International Classification:
    A61K 47/18
  • US Classification:
    4242831, 562565, 514785, 514 44 R, 514 44 A, 435375, 562571
  • Abstract:
    The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

  • Biodegradable Lipids For The Delivery Of Active Agents

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  • US Patent:
    20120027803, Feb 2, 2012
  • Filed:
    Jun 3, 2011
  • Appl. No.:
    13/153200
  • Inventors:
    Muthiah MANOHARAN - Cambridge MA, US
    Martin Maier - Cambridge MA, US
    Muthusamy Jayaraman - Cambridge MA, US
    Shigeo Matsuda - Cambridge MA, US
    Akin Akinc - Cambridge MA, US
    Thomas A. Baillie - Seattle WA, US
  • Assignee:
    ALNYLAM PHARMACEUTICALS, INC. - Cambridge MA
  • International Classification:
    A61K 47/44
    A61K 31/713
    A61P 37/04
    C12N 5/071
    C12N 15/85
    C07C 229/30
    A61K 31/7088
  • US Classification:
    4242831, 554110, 514785, 514 44 A, 514 44 R, 435375, 435455
  • Abstract:
    The present invention relates to a cationic lipid having one or more biodegradable groups located in the mid- or distal section of a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

  • Biodegradable Lipids For The Delivery Of Active Agents

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  • US Patent:
    20220347302, Nov 3, 2022
  • Filed:
    Apr 29, 2021
  • Appl. No.:
    17/302310
  • Inventors:
    - Cambridge MA, US
    Muthusamy Jayaraman - Cambridge MA, US
    Akin Akinc - Cambridge MA, US
    Shigeo Matsuda - Cambridge MA, US
    Pachamuthu Kandasamy - Cambridge MA, US
    Muthiah Manoharan - Cambridge MA, US
  • International Classification:
    A61K 47/18
    A61K 9/127
    A61K 9/51
    A61K 31/713
    C07D 317/30
    C07C 211/09
    C07C 211/10
    C07C 211/11
    C07C 217/08
    C07C 229/12
    C07C 327/22
    C07C 327/28
    C07C 327/32
    C07C 235/06
    C07C 251/38
    C07F 5/02
    C07D 233/54
    C07D 207/32
    C07D 295/08
    C07D 295/12
    C07D 295/14
    C07C 323/12
    C07C 323/58
    C07C 31/125
    A61K 31/7088
    A61K 31/7105
  • Abstract:
    The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

  • Oligonucleotide-Ligand Conjugates And Process For Their Preparation

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  • US Patent:
    20220348914, Nov 3, 2022
  • Filed:
    Oct 2, 2020
  • Appl. No.:
    17/062422
  • Inventors:
    - CAMBRIDGE MA, US
    Jayaprakash K. Nair - Cambridge MA, US
    Pachamuthu Kandasamy - Cambridge MA, US
    Shigeo Matsuda - Cambridge MA, US
    Alexander V. Kelin - Cambridge MA, US
    Muthusamy Jayaraman - Cambridge MA, US
  • International Classification:
    C12N 15/113
    C07H 21/00
    C12N 15/11
    A61K 47/54
  • Abstract:
    The present invention relates to ligand conjugates of oligonucleotides (e.g., iRNA agents) and methods for their preparation. The ligands are derived primarily from monosaccharides These conjugates are useful for the in vivo delivery of oligonucleotides.

  • Biodegradable Lipids For The Delivery Of Active Agents

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  • US Patent:
    20220249670, Aug 11, 2022
  • Filed:
    Feb 14, 2022
  • Appl. No.:
    17/651017
  • Inventors:
    - Cambridge MA, US
    Muthusamy Jayaraman - Cambridge MA, US
    Akin Akinc - Cambridge MA, US
    Shigeo Matsuda - Cambridge MA, US
    Pachamuthu Kandasamy - Cambridge MA, US
    Muthiah Manoharan - Cambridge MA, US
  • International Classification:
    A61K 47/18
    A61K 9/127
    A61K 9/51
    A61K 31/713
    C07D 317/30
    C07C 211/09
    C07C 211/10
    C07C 211/11
    C07C 217/08
    C07C 229/12
    C07C 327/22
    C07C 327/28
    C07C 327/32
    C07C 235/06
    C07C 251/38
    C07F 5/02
    C07D 233/54
    C07D 207/32
    C07D 295/08
    C07D 295/12
    C07D 295/14
    C07C 323/12
    C07C 323/58
    C07C 31/125
    A61K 31/7088
    A61K 31/7105
  • Abstract:
    The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

  • Biodegradable Lipids For The Delivery Of Active Agents

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  • US Patent:
    20220175928, Jun 9, 2022
  • Filed:
    Feb 14, 2022
  • Appl. No.:
    17/651023
  • Inventors:
    - Cambridge MA, US
    Muthusamy Jayaraman - Cambridge MA, US
    Akin Akinc - Cambridge MA, US
    Shigeo Matsuda - Cambridge MA, US
    Pachamuthu Kandasamy - Cambridge MA, US
    Muthiah Manoharan - Cambridge MA, US
  • International Classification:
    A61K 47/18
    A61K 9/127
    A61K 9/51
    A61K 31/713
    C07D 317/30
    C07C 211/09
    C07C 211/10
    C07C 211/11
    C07C 217/08
    C07C 229/12
    C07C 327/22
    C07C 327/28
    C07C 327/32
    C07C 235/06
    C07C 251/38
    C07F 5/02
    C07D 233/54
    C07D 207/32
    C07D 295/08
    C07D 295/12
    C07D 295/14
    C07C 323/12
    C07C 323/58
    C07C 31/125
    A61K 31/7088
    A61K 31/7105
  • Abstract:
    The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

Wikipedia

A Pale View of Hills

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... of noodle shop who gave Sachiko a job; Hanada Jiro's friend who threatened his wife with a golf club; Shigeo Matsuda a student in Ogata-san's class ...

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Shigeo Matsuda ( )

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Shigeo Matsuda Photo 2

Shigeo Matsuda ( )

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Friends: Kiyooka Kenji, Takashi Tani, Issei Sawada, Emi Naito, Souichi Hijikata, Shigeo MatsudaFacebookFacebookShigeo Matsuda Facebook ...

Youtube

Haruka Entry for ShigeoX3

Haruka Entry for ShigeoX3

Alright yes it's a nother entry....But it's Haruka this timeXD And YES...

  • Category:
    Entertainment
  • Uploaded:
    25 Jul, 2009
  • Duration:
    59s

Plaxo

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Shigeo Matsuda's Public

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Shigeo Matsuda's Public Profile on Plaxo. Plaxo helps members like Shigeo Matsuda keep in touch with the people who really matter, helping them to connect , ...
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Shigeo Matsuda

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Scientist at Alnylam Pharmaceuticals
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