Shu Fen Chen

US Patent:

20020127512, Sep 12, 2002

Filed:

Feb 21, 2002

Appl. No.:

10/080311

Inventors:

Shu Chen - Buffalo Grove IL, US
Richard Paschke - Timonium MD, US
Anisur Rahman - Gurnee IL, US
David Tipton - Rolling Meadows IL, US

International Classification:

A61C003/03
A61C001/08

US Classification:

433/119000, 433/126000

Abstract:

An adapter for use with a piezoelectric and/or magnetostrictive ultrasonic unit can be coupled between the handpiece and the cable. The adapter includes a symmetrically oriented flow path with offset ends to mate with the handpiece and the cable respectively. The adapter also includes a rotary electrical connection facilitating the transfer of energy from the cable to the handpiece while the handpiece is being rotated. The rotary connection of the adapter can be integrated into either of the handpiece or the cable termination.

US Patent:

20030008814, Jan 9, 2003

Filed:

May 21, 2002

Appl. No.:

10/130835

Inventors:

Shu Chen - Carmel IN, US
Xicheng Sun - Superior CO, US
Yanzhi Zhang - Sharon MA, US

International Classification:

A61K038/12
C07K007/50

US Classification:

514/009000, 530/317000

Abstract:

A pseudomycin prodrug represented by structure (A) where R1 is a phosphate benzyloxycarbamate or phosphate methyleneoxycarbamate linkage is described. The phosphate prodrug demonstrates antifungal activity with less adverse side effects than the parent pseudomycin compound.

US Patent:

20040265776, Dec 30, 2004

Filed:

Mar 10, 2004

Appl. No.:

10/797171

Inventors:

David Tipton - Rolling Meadows IL, US
Patricia Parker - Midlothian IL, US
Shu Chen - Buffalo Grove IL, US

International Classification:

A61C003/03

US Classification:

433/119000

Abstract:

A low flow ultrasonic insert has an internal fluid flow channel which extends between an operative tip geometry and a body portion of insert. The channel terminates at the tip geometry with a fluid flow output. A fluid flow input is provided for the channel in the body portion where a transverse slot intersects the channel.

US Patent:

20140294763, Oct 2, 2014

Filed:

Jun 17, 2014

Appl. No.:

14/306778

Inventors:

- Boston MA, US
Shu Hui Chen - Carmel IN, US
Ivan Collado-Cano - Madrid, ES
Maria Cristina Garcia Paredes - Madrid, ES
John Irvin Glass - Indianapolis IN, US
Ling Jin - Carmel IN, US
Jason Eric Lamar - Indianapolis IN, US
Nancy June Snyder - Lizton IN, US
Xicheng David Sun - Superior CO, US
Deqi Guo - Carmel IN, US
Yvonne Yee Mai Yip - Indianapolis IN, US
May Q. Wang - Indianapolis IN, US
Victor Frantz - Indianapolis IN, US
Mark Joseph Tebbe - Hamburg, DE
Robert B. Perni - Marlborough MA, US
Luc J. Farmer - Montreal, CA

International Classification:

C07K 7/02
A61K 38/21
A61K 45/06
C07K 5/103
A61K 38/07
A61K 38/08
C07D 209/52

US Classification:

424 852, 530323, 514 43, 424 854, 424 857, 424 856, 435184, 435375

Abstract:

The present invention relates to peptidomimetic compounds useful as protease inhibitors, particularly as serine protease inhibitors and more particularly as hepatitis C NS3 protease inhibitors; intermediates thereto; their preparation including novel steroselective processes to intermediates. The invention is also directed to pharmaceutical compositions and to methods for using the compounds for inhibiting HCV protease or treating a patient suffering from an HCV infection or physiological condition related to the infection. Also provided are pharmaceutical combinations comprising, in addition to one or more HCV serine protease inhibitors, one or more interferons exhibiting anti-HCV activity and/or one or more compounds having anti HCV activity and a pharmaceutically acceptable carrier, and methods for treating or preventing a HCV infection in a patient using the compositions. The present invention is also directed to a kit or pharmaceutical pack for treating or preventing HCV infection in a patient.