Shu Liu Chen

US Patent:

8529882, Sep 10, 2013

Filed:

Jul 3, 2012

Appl. No.:

13/541436

Inventors:

Robert Edward Babine - Franklin MA, US
Shu Hui Chen - Carmel IN, US
Ivan Collado - Madrid, ES
Cristina Garcia-Paredes - Madrid, ES
John Irvin Glass - Indianapolis IN, US
Ling Jin - Carmel IN, US
Jason Eric Lamar - Indianapolis IN, US
Nancy June Snyder - Lizton IN, US
Xicheng David Sun - Superior CO, US
Deqi Guo - Carmel IN, US
Yvonne Yee Mai Yip - Indianapolis IN, US
Frantz Victor - Indianapolis IN, US
Mark Joseph Tebbe - Hamburg, DE
Robert B. Perni - Marlborough MA, US
Luc Farmer - Montreal, CA

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

A61K 38/07
A61K 38/20
A61K 38/21
C07D 209/52
C12N 5/073
C12N 9/99
A61P 31/14
C07K 5/117

US Classification:

424 852, 424 854, 424 857, 435184, 435375, 517 43, 530330, 548515

Abstract:

The present invention relates to peptidomimetic compounds useful as protease inhibitors, particularly as serine protease inhibitors and more particularly as hepatitis C NS3 protease inhibitors; intermediates thereto; their preparation including novel stereoselective processes to intermediates. The invention is also directed to pharmaceutical compositions and to methods for using the compounds for inhibiting HCV protease or treating a patient suffering from an HCV infection or physiological condition related to the infection. Also provided are pharmaceutical combinations comprising, in addition to one or more HCV serine protease inhibitors, one or more interferons exhibiting anti-HCV activity and/or one or more compounds having anti HCV activity and a pharmaceutically acceptable carrier, and methods for treating or preventing a HCV infection in a patient using the compositions. The present invention is also directed to a kit or pharmaceutical pack for treating or preventing HCV infection in a patient.

US Patent:

20050235042, Oct 20, 2005

Filed:

Apr 16, 2004

Appl. No.:

10/826109

Inventors:

Todd Rumaner - Livermore CA, US
Shu Chen - Fremont CA, US
Michael Mulqueen - San Ramon CA, US

International Classification:

G06F015/167

US Classification:

709216000

Abstract:

A method for a memory device utility program includes (1) detecting a memory device being coupled to a host device, (2) in response to said detecting, locating files on the memory device, (3) displaying a file transfer page comprising a file transfer button for transferring the files on the memory device to the host device, and (4) in response to a user selecting the transfer button, transferring the files on the memory device to the host device.

US Patent:

20120064034, Mar 15, 2012

Filed:

Nov 10, 2011

Appl. No.:

13/293812

Inventors:

ROBERT EDWARD BABINE - FRANKLIN MA, US
SHU HUI CHEN - CARMEL IN, US
IVAN COLLADO - MADRID, ES
CRISTINA GARCIA-PAREDES - MADRID, ES
JOHN IRVIN GLASS - INDIANAPOLIS IN, US
DEQI GUO - CARMEL IN, US
LING JIN - CARMEL IN, US
JASON ERIC LAMAR - INDIANAPOLIS IN, US
NANCY JUNE SNYDER - LIZTON IN, US
XICHENG DAVID SUN - SUPERIOR CO, US
YVONNE YEE MAI YIP - INDIANAPOLIS IN, US
FRANTZ VICTOR - INDIANAPOLIS IN, US
MARK JOSEPH TEBBE - HAMBURG, DE
ROBERT B. PERNI - MARLBOROUGH MA, US
LUC FARMER - FOXBOROUGH MA, US

Assignee:

VERTEX PHARMACEUTICALS INCORPORATED - CAMBRIDGE MA

International Classification:

A61K 38/08
C07K 5/037
A61K 38/21
C12N 5/071
C07C 229/42
C07D 209/52
C12N 9/99
C07K 7/06
A61K 38/20

US Classification:

424 852, 530330, 514 37, 424 854, 424 857, 560 43, 548512, 548515, 435184, 435375

Abstract:

The present invention relates to peptidomimetic compounds useful as protease inhibitors, particularly as serine protease inhibitors and more particularly as hepatitis C NS3 protease inhibitors; intermediates thereto; their preparation including novel steroselective processes to intermediates. The invention is also directed to pharmaceutical compositions and to methods for using the compounds for inhibiting HCV protease or treating a patient suffering from an HCV infection or physiological condition related to the infection. Also provided are pharmaceutical combinations comprising, in addition to one or more HCV serine protease inhibitors, one or more interferons exhibiting anti-HCV activity and/or one or more compounds having anti HCV activity and a pharmaceutically acceptable carrier, and methods for treating or preventing a HCV infection in a patient using the compositions. The present invention is also directed to a kit or pharmaceutical pack for treating or preventing HCV infection in a patient.

US Patent:

20130292393, Nov 7, 2013

Filed:

Jan 25, 2013

Appl. No.:

13/750050

Inventors:

Richard Kevin Sennett - Abington MA, US
Shu Chen - Long Grove IL, US

Assignee:

The Gillette Company - Boston MA

International Classification:

B65D 1/36
B65D 1/40

US Classification:

220608, 220675

Abstract:

A consumer product package comprising a tub comprising a base and a perimeter wall defining a cavity, the base comprising at least two projections extending from the base within the cavity, the at least two projections spaced apart from the perimeter wall; and a consumer product disposed within the cavity such that each of the at least two projections define a recessed portion to receive the consumer product, wherein the base comprises a secondary projection having a height different than a height of each of the at least two projections, the secondary projection free of contact from the consumer product.

US Patent:

20170200438, Jul 13, 2017

Filed:

Jan 8, 2017

Appl. No.:

15/401033

Inventors:

Shu Chun Chen - Lexington MA, US

International Classification:

G10K 11/04
A61F 11/08
G10K 13/00

Abstract:

Micro-fabricated acoustic attenuation devices are described. One such device includes 1) a substrate, 2) a movable diaphragm supported by springs that anchors to the substrate, and 3) a stationary proliferated backplane which is separated by an air gap, whereby sound pressure causes the movable diaphragm to vibrate and when the sound exceeds threshold, the movable diaphragm deflects and presses against the proliferated backplane restricting further movement thus attenuates incoming sound.Another device includes 1) a substrate, 2) a movable diaphragm wherein the diaphragm has at least one hole on it, and 3) a stationary proliferated backplane which is separated by an air gap, whereby sound pressure causes the movable diaphragm to vibrate and when the sound exceeds threshold, the movable diaphragm deflects and presses against the proliferated backplane restricting further movement thus attenuates incoming sound. Methods of producing the micro-fabricated acoustic attenuation device are also described.

US Patent:

20170200440, Jul 13, 2017

Filed:

Jan 8, 2017

Appl. No.:

15/401032

Inventors:

Shu Chun Chen - Lexington MA, US

International Classification:

G10K 11/162
A61F 11/08
A61F 11/14
G10K 13/00

Abstract:

Micro-fabricated acoustic attenuation devices are described. One such device includes 1) a substrate, 2) a movable diaphragm supported by springs that anchors to the substrate, and 3) a stationary proliferated backplane which is separated by an air gap, whereby sound pressure causes the movable diaphragm to vibrate and when the sound exceeds threshold, the movable diaphragm deflects and presses against the proliferated backplane restricting further movement thus attenuates incoming sound.Another device includes 1) a substrate, 2) a movable diaphragm wherein the diaphragm has at least one hole on it, and 3) a stationary proliferated backplane which is separated by an air gap, whereby sound pressure causes the movable diaphragm to vibrate and when the sound exceeds threshold, the movable diaphragm deflects and presses against the proliferated backplane restricting further movement thus attenuates incoming sound. Methods of producing the micro-fabricated acoustic attenuation device are also described.

US Patent:

20160244198, Aug 25, 2016

Filed:

Feb 19, 2015

Appl. No.:

14/625727

Inventors:

- Boston MA, US
Richard Kevin Sennett - Abington MA, US
Shu Chen - Long Grove IL, US

International Classification:

B65D 1/34
B65D 21/02

Abstract:

A consumer product package comprising a tub comprising a base and a perimeter wall defining a cavity, the base comprising at least two projections extending from the base within the cavity, the at least two projections spaced apart from the perimeter wall; and a consumer product disposed within the cavity such that each of the at least two projections define a recessed portion to receive the consumer product, wherein the base comprises a secondary projection having a height different than a height of each of the at least two projections, the secondary projection free of contact from the consumer product.