Si Chen

US Patent:

20210153854, May 27, 2021

Filed:

May 15, 2018

Appl. No.:

16/614072

Inventors:

- Ithaca NY, US
Roger HARTL - New York NY, US
Monika MCCARTER - Monroe CT, US
Michael MESSINA - Washingtonville NY, US
Gayathri SHIBU - Ithaca NY, US
Si CHEN - Ithaca NY, US

International Classification:

A61B 17/00

Abstract:

A device comprising a housing including a palm portion, a sheath portion extending from one end of the palm portion, and a slot comprising an adjustable platform capable of receiving a syringe and a needle connected to the syringe with the needle resting in the sheath portion. A trigger mechanism is connected to the adjustable platform. Adjustment of the trigger mechanism in a first direction moves the platform along the slot toward the sheath portion and adjustment of the bidirectional trigger mechanism in a second direction moves the platform away from the sheath. A light element is connected to the housing and is capable of directing light along the sheath portion away from the palm portion. A power source is electrically coupled to the light element to provide electrical power to the light element. Also disclosed is a system comprising the device, as well as methods of using the device.

US Patent:

20170224838, Aug 10, 2017

Filed:

Apr 24, 2017

Appl. No.:

15/495474

Inventors:

- La Jolla CA, US
Rong XIANG - San Diego CA, US
Yunping LUO - San Diego CA, US
Debbie LIAO - San Diego CA, US
Ze LIU - Beijing, CN
Tingmei CHEN - Chongqing, CN
Si CHEN - Little Rock AR, US
Dan LU - San Diego CA, US

Assignee:

The Scripps Research Institute - La Jolla CA

International Classification:

A61K 9/127
A61K 31/58
A61K 47/28
A61K 31/704

Abstract:

An aqueous tumor-targeting liposome nanoparticle composition comprises an aqueous dispersion of liposome nanoparticles. The nanoparticles preferably encapsulate an anti-cancer chemotherapeutic agent, which can be added to a pre-formed liposome composition or can be incorporated in the liposomes during the formation of the liposomes. The liposome nanoparticles comprise a legumain-targeting lipid admixed with one or more other micelle or vesicle-forming lipid materials in the form of nanoparticulate liposomes dispersed in an aqueous carrier. A preferred tumor-targeting liposome nanoparticle composition comprises a legumain-targeting lipid component and polyethylene glycol-conjugated lipid component. The legumain-targeting lipid component comprising a hydrophobic lipid portion covalently attached to a legumain-binding moiety.