Simeon G Bowers from 3252 Birdsall Ave, Oakland, CA 94619, age 51, Phone: 5105359378

Bridged N-Cyclic Sulfonamido Inhibitors Of Gamma Secretase
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US Patent:

7754712, Jul 13, 2010
Filed:

Dec 5, 2007
Appl. No.:

11/951097
Inventors:

Simeon Bowers - Oakland CA, US
Albert W. Garofalo - South San Francisco CA, US
Roy K. Hom - San Francisco CA, US
Andrei W. Konradi - Burlingame CA, US
Matthew N. Mattson - Santa Clara CA, US
Martin L. Neitzel - Pacifica CA, US
Christopher M. Semko - Fremont CA, US
Anh P. Truong - Burlingame CA, US
Jing Wu - Redwood City CA, US
Ying-zi Xu - Palo Alto CA, US
Assignee:

Elan Pharmaceuticals, Inc. - South San Francisco CA
International Classification:

A61K 31/5365
A61K 31/437
A61K 31/4985
A61P 25/28
C07D 497/04
C07D 497/14
C07D 471/14
US Classification:

5142302, 5142305, 514250, 514293, 544101, 544105, 544346, 546 82
Abstract:

The invention provides N-cyclic sulfonamido compounds and salts of Formula I:wherein A is as described in the specification and Rand Rcombine to form a [3. 3. 1] or a [3. 2. 1] ring system, where the nitrogen is attached to the two bridgehead carbons, and the [3. 3. 1] or [3. 2. 1] ring systems are optionally fused with an heteroaryl or heterocycloalkyl ring. Compounds of Formula I are useful in treating or preventing cognitive disorders, such as Alzheimer's Disease. The invention also encompasses pharmaceutical compositions comprising compounds of Formula I, methods of treating cognitive disorders, such as Alzheimer's disease, and the intermediates useful in preparing the compounds of Formula I.

Substituted Hydroxyethylamine Aspartyl Protease Inhibitors
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US Patent:

7858642, Dec 28, 2010
Filed:

Mar 3, 2009
Appl. No.:

12/396989
Inventors:

Varghese John - San Francisco CA, US
Michel Maillard - Redwood City CA, US
John Tucker - San Diego CA, US
Jose Aquino - Daly City CA, US
Barbara Jagodzinska - Redwood City CA, US
Louis Brogley - Santa Cruz CA, US
Jay S. Tung - Belmont CA, US
Simeon Bowers - Oakland CA, US
Darren Dressen - Fremont CA, US
Gary Probst - San Francisco CA, US
Neerav Shah - San Mateo CA, US
Assignee:

Elan Pharmaceuticals, Inc. - South San Francisco CA
International Classification:

A61K 31/427
A61K 31/4709
C07D 215/58
C07D 285/04
US Classification:

514314, 514362, 546159, 548128
Abstract:

The invention relates to novel compounds and also to methods of treating at least one disease, disorder, or condition associated with amyloidosis using such compounds. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.

Pyrazolopyrrolidines As Inhibitors Of Gamma Secretase
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US Patent:

7977368, Jul 12, 2011
Filed:

May 21, 2008
Appl. No.:

12/124358
Inventors:

Darren Dressen - Fremont CA, US
Simeon Bowers - Oakland CA, US
Albert W. Garofalo - South San Francisco CA, US
Roy K. Hom - San Francisco CA, US
Matthew N. Mattson - Santa Clara CA, US
Assignee:

Elan Pharmaceuticals, Inc. - South San Francisco CA
International Classification:

A61K 31/40
A61K 31/4162
C07D 231/54
US Classification:

514406, 514360, 514408, 514422, 548122, 548400, 548416, 548418, 548518
Abstract:

The invention provides compounds of Formula I.

N-Sulfonamido Polycyclic Pyrazolyl Compounds
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US Patent:

8283358, Oct 9, 2012
Filed:

Sep 4, 2009
Appl. No.:

12/554134
Inventors:

Andrei W. Konradi - Burlingame CA, US
Xiaocong Michael Ye - Palo Alto CA, US
Simeon Bowers - Oakland CA, US
Albert W. Garofalo - South San Francisco CA, US
Danielle L. Aubele - Burlingame CA, US
Darren Dressen - Fremont CA, US
Raymond Ng - San Ramon CA, US
Gary Probst - San Francisco CA, US
Christopher M. Semko - Fremont CA, US
Minghua Sun - Burlingame CA, US
Anh P. Truong - Burlingame CA, US
Michael S. Dappen - Emerald Hills CA, US
Assignee:

Elan Pharmaceuticals, Inc. - South San Francisco CA
International Classification:

A61K 31/439
C07D 471/18
US Classification:

514286, 546 63
Abstract:

The current invention provides compounds having a structure according to Formulae 1, 2, 3, and 4:.

Inhibitors Of Polo-Like Kinase
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US Patent:

8445503, May 21, 2013
Filed:

Dec 21, 2010
Appl. No.:

12/974401
Inventors:

Robert A. Galemmo - San Francisco CA, US
Dean R. Artis - Kensington CA, US
Xiaocong Michael Ye - Palo Alto CA, US
Danielle Aubele - Burlingame CA, US
Anh Truong - Burlingame CA, US
Simeon Bowers - Oakland CA, US
Roy K. Hom - San Francisco CA, US
Yong-Liang Zhu - Fremont CA, US
R. Jeffrey Neitz - San Francisco CA, US
Jennifer Sealy - Oakland CA, US
Marc Adler - Orinda CA, US
Paul Beroza - Belmont CA, US
John P. Anderson - San Francisco CA, US
Assignee:

Elan Pharmaceuticals, Inc. - South San Francisco CA
International Classification:

A01N 43/54
A61K 31/505
C07D 491/00
US Classification:

514267, 544251
Abstract:

The present invention provides compounds having a structure according to Formula (I):.

Inhibitors Of Jun N-Terminal Kinase
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US Patent:

8450363, May 28, 2013
Filed:

Feb 5, 2010
Appl. No.:

12/701474
Inventors:

Hing L. Sham - Palo Alto CA, US
Roy K. Hom - San Francisco CA, US
Andrei W. Konradi - Burlingame CA, US
Gary D. Probst - San Francisco CA, US
Simeon Bowers - Oakland CA, US
Anh Truong - Burlingame CA, US
R. Jeffrey Neitz - San Francisco CA, US
Jennifer Sealy - Oakland CA, US
Gergely Toth - Palo Alto CA, US
Assignee:

Elan Pharmaceuticals, Inc. - South San Francisco CA
International Classification:

A61K 31/38
A01N 43/06
C07D 333/36
US Classification:

514447, 549 69
Abstract:

The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula:.

Inhibitors Of Polo-Like Kinase
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US Patent:

8541418, Sep 24, 2013
Filed:

Dec 21, 2010
Appl. No.:

12/974622
Inventors:

Robert A. Galemmo - San Francisco CA, US
Dean R. Artis - Kensington CA, US
Xiaocong Michael Ye - Palo Alto CA, US
Danielle Aubele - Burlingame CA, US
Anh Truong - Burlingame CA, US
Simeon Bowers - Oakland CA, US
Roy K. Hom - San Francisco CA, US
Yong-Liang Zhu - Fremont CA, US
R. Jeffrey Neitz - San Francisco CA, US
Jennifer Sealy - Oakland CA, US
Marc Adler - Orinda CA, US
Paul Beroza - Belmont CA, US
John P. Anderson - San Francisco CA, US
Assignee:

Elan Pharmaceutical, Inc. - South San Francisco CA
International Classification:

A61K 31/4965
C07D 475/00
US Classification:

51425505, 544258
Abstract:

The present invention provides compounds having a structure according to Formula (I):.

Methods Of Treatment Of Amyloidosis Using Bi-Cyclic Aspartyl Protease Inhibitors
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US Patent:

20050239832, Oct 27, 2005
Filed:

Mar 9, 2005
Appl. No.:

11/074828
Inventors:

Varghese John - San Francisco CA, US
Michel Maillard - Redwood City CA, US
Lawrence Fang - Foster City CA, US
John Tucker - San Diego CA, US
Louis Brogley - Santa Cruz CA, US
Jose Aquino - Daly City CA, US
Simeon Bowers - Oakland CA, US
Gary Probst - San Francisco CA, US
Jay Tung - Belmont CA, US
International Classification:

A61K031/381
A61K031/137
A61K031/35
A61K031/445
US Classification:

514317000, 514447000, 514459000, 514649000, 514326000, 514444000
Abstract:

The invention relates to novel compounds and methods of treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.

Simeon G Bowers