Simon J Prosser

US Patent:

6627882, Sep 30, 2003

Filed:

Dec 22, 2000

Appl. No.:

09/748518

Inventors:

Gary A. Schultz - Ithaca NY
Thomas N. Corso - Lansing NY
Simon J. Prosser - Ithaca NY

Assignee:

Advion Biosciences, Inc. - Ithaca NY

International Classification:

H01J 4904

US Classification:

250288, 250281, 250282, 250423 R

Abstract:

A microchip-based electrospray device, system, and method of fabrication thereof are disclosed. The electrospray device includes a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electric field generating source for application of an electric potential to the substrate to optimize and generate an electrospray. A method and system are disclosed to generate multiple electrospray plumes from a single fluid stream that provides an ion intensity as measured by a mass spectrometer that is approximately proportional to the number of electrospray plumes formed for analytes contained within the fluid. A plurality of electrospray nozzle devices can be used in the form of an array of miniaturized nozzles for the purpose of generating multiple electrospray plumes from multiple nozzles for the same fluid stream. This invention dramatically increases the sensitivity of microchip electrospray devices compared to prior disclosed systems and methods.

US Patent:

6723985, Apr 20, 2004

Filed:

Jan 23, 2003

Appl. No.:

10/350542

Inventors:

Gary A. Schultz - Ithaca NY
Thomas N. Corso - Lansing NY
Simon J. Prosser - Ithaca NY

Assignee:

Advion BioSciences, Inc. - Ithaca NY

International Classification:

H01J 4904

US Classification:

250288, 250281, 250282, 250423 R, 430320, 430314, 2101982, 210748

Abstract:

A microchip-based electrospray device, system, and method of fabrication thereof are disclosed. The electrospray device includes a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electric field generating source for application of an electric potential to the substrate to optimize and generate an electrospray. A method and system are disclosed to generate multiple electrospray plumes from a single fluid stream that provides an ion intensity as measured by a mass spectrometer that is approximately proportional to the number of electrospray plumes formed for analytes contained within the fluid. A plurality of electrospray nozzle devices can be used in the form of an array of miniaturized nozzles for the purpose of generating multiple electrospray plumes from multiple nozzles for the same fluid stream. This invention dramatically increases the sensitivity of microchip electrospray devices compared to prior disclosed systems and methods.

US Patent:

6811689, Nov 2, 2004

Filed:

Sep 9, 2003

Appl. No.:

10/658006

Inventors:

Sheng Zhang - Ithaca NY
Xian Huang - Ithaca NY
Thomas N. Corso - Lansing NY
Gary A. Schultz - Ithaca NY
Simon J. Prosser - Ithaca NY

Assignee:

Advion BioSciences, Inc. - Ithaca NY

International Classification:

B01D 1508

US Classification:

2101982, 210243, 210656, 210748, 204600, 250288, 422 70

Abstract:

A microchip-based electrospray ionization device and column with affinity adsorbents is disclosed. The invention includes a microchip array and a capillary tube or alone or attached in combination. At least a portion of the device or column has immobilized affinity adsorbents. Methods for using the device are provided as well for affinity capture of biomolecules to meet the needs for the modern life sciences such as proteomics and drug discover.

US Patent:

6814870, Nov 9, 2004

Filed:

Sep 9, 2003

Appl. No.:

10/658008

Inventors:

Sheng Zhang - Ithaca NY
Xian Huang - Ithaca NY
Thomas N. Corso - Lansing NY
Gary A. Schultz - Ithaca NY
Simon J. Prosser - Ithaca NY

Assignee:

Advion BioSciences, Inc. - Ithaca NY

International Classification:

B01D 1508

US Classification:

210656, 210748, 2101982, 210243, 204450, 250288, 436161

Abstract:

A microchip-based electrospray ionization device and column with affinity adsorbents is disclosed. The invention includes a microchip array and a capillary tube or alone or attached in combination. At least a portion of the device or column has immobilized affinity adsorbents. Methods for using the device are provided as well for affinity capture of biomolecules to meet the needs for the modem life sciences such as proteomics and drug discover.

US Patent:

6956207, Oct 18, 2005

Filed:

Apr 1, 2003

Appl. No.:

10/405689

Inventors:

Thomas N. Corso - Lansing NY, US
Gary A. Schultz - Ithaca NY, US
Simon J. Prosser - Ithaca NY, US
Xian Huang - Ithaca NY, US

Assignee:

Advion BioScience, Inc. - Ithaca NY

International Classification:

H01J049/00
B01D059/44

US Classification:

250288, 250281

Abstract:

A microfabricated silicon chip with a separation material, such as in situ prepared porous polymer monoliths in its microchannels is disclosed. The polymer monoliths are liquid-permeable and serve as microcolumns for liquid chromatography, which are prepared by in situ radical polymerization of a mixture containing vinyl monomers and solvents (porogen) in the microchannels. A method and system are disclosed to generate one or more electrospray plumes from one or more nozzles that provide an ion intensity as measured by a mass spectrometer that is approximately proportional to the number of electrospray plumes formed for analyses contained within the fluid. A plurality of electrospray devices can be used in the form of an array of miniaturized separate electrospray devices for the purpose of generating multiple electrospray plumes from multiple nozzles for the same fluid for analysis. This invention dramatically increases the sensitivity of microchip electrospray devices compared to prior disclosed systems and methods. The silicon chip having the packed microchannels disclosed herein finds application in coupling with mass spectrometry for sample analysis.

US Patent:

8373118, Feb 12, 2013

Filed:

Aug 18, 2011

Appl. No.:

13/212259

Inventors:

Simon Prosser - Ithaca NY, US
Jack Henion - Ithaca NY, US
Stephen Thompson - Old Trafford, GB
Vic Parr - Old Trafford, GB

Assignee:

Advion, Inc. - Ithaca NY
Scientific Analysis Instruments Ltd. - Manchester

International Classification:

H01J 49/26
H01J 49/00

US Classification:

250288, 250281, 250282, 250289

Abstract:

Methods and systems for mass spectrometry and more particularly to an interface providing charged particles to a mass spectrometer are described herein.

US Patent:

8487247, Jul 16, 2013

Filed:

Aug 1, 2012

Appl. No.:

13/563991

Inventors:

Simon Prosser - Ithaca NY, US
Jack Henion - Ithaca NY, US
Stephen Thompson - Manchester, GB
Vic Parr - Manchester, GB

Assignee:

Advion Inc. - Ithaca NY
Scientific Analysis Instruments Ltd. - Manchester

International Classification:

H01J 49/26
H01J 49/00

US Classification:

250288, 250281, 250282, 250289

Abstract:

Methods and systems for mass spectrometry and more particularly to an interface providing charged particles to a mass spectrometer are described herein.

US Patent:

20020000517, Jan 3, 2002

Filed:

Jan 18, 2001

Appl. No.:

09/764698

Inventors:

Thomas Corso - Lansing NY, US
Gary Schultz - Ithaca NY, US
Simon Prosser - Ithaca NY, US
Xian Huang - Ithaca NY, US

International Classification:

H01J049/00
B01D059/44

US Classification:

250/288000

Abstract:

A microfabricated silicon chip with a separation material, such as in situ prepared porous polymer monoliths in its microchannels is disclosed. The polymer monoliths are liquid-permeable and serve as microcolumns for liquid chromatography, which are prepared by in situ radical polymerization of a mixture containing vinyl monomers and solvents (porogen) in the microchannels. A method and system are disclosed to generate one or more electrospray plumes from one or more nozzles that provide an ion intensity as measured by a mass spectrometer that is approximately proportional to the number of electrospray plumes formed for analyses contained within the fluid. A plurality of electrospray devices can be used in the form of an array of miniaturized separate electrospray devices for the purpose of generating multiple electrospray plumes from multiple nozzles for the same fluid for analysis. This invention dramatically increases the sensitivity of microchip electrospray devices compared to prior disclosed systems and methods. The silicon chip having the packed microchannels disclosed herein finds application in coupling with mass spectrometry for sample analysis. Also disclosed is a separation block having multiple through-substrate channels filled with a separation material such as polymer monolith which can be stacked in multiple blocks for sequential two-dimensional chromatographic separation and integrated with the electrospray device.