Spencer David Kimball - East Windsor NJ Louis J. Lombardo - Belle Mead NJ David B. Rawlins - Morrisville PA Robert J. Schmidt - Hainesport NJ David K. Williams - Delran NJ
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
A61K 31513
US Classification:
514256, 514274, 544316, 544323, 544324
Abstract:
The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds induce mitotic arrest thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases which can be treated by inducing mitotic arrest.
Joseph Barbosa - Lambertville NJ, US Cynthia A. Fink - Lebanon NJ, US Spencer D. Kimball - East Windsor NJ, US Hartmuth Kolb - Marina Del Rey CA, US Zhi-Cai Shi - Monmouth Junction NJ, US Ashok R. Tunoori - East Windsor NJ, US
Assignee:
Lexicon Pharmaceuticals, Inc. - The Woodlands TX
International Classification:
C07D 513/02 A61K 31/429
US Classification:
514366, 548153
Abstract:
This invention concerns novel thiazolopyrazole compounds and compositions comprising them. Methods of using these compounds for the treatment, prevention and management of various diseases and disorders are also encompassed by the invention.
Imidazole-Based Compounds, Compositions Comprising Them And Methods Of Their Use
David J. Augeri - Princeton NJ, US Jeffrey Bagdanoff - Robbinsville NJ, US Lakmal W. Boteju - Kendall Park NJ, US Kenneth G. Carson - Princeton NJ, US Theodore C. Jessop - Lawrenceville NJ, US Spencer David Kimball - East Windsor NJ, US
Assignee:
Lexicon Pharmaceuticals, Inc. - The Woodlands TX
International Classification:
C07D 233/64 A61K 31/4164
US Classification:
5483361, 5483355, 5483365, 514400
Abstract:
Imidazole-based compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed. Particular compounds are of formula I:.
Inhibitors Of Sodium Glucose Co-Transporter 2 And Methods Of Their Use
Bryce Alden Harrison - Hamilton NJ, US Spencer David Kimball - East Windsor NJ, US Ross Mabon - Princeton NJ, US David Brent Rawlins - Morrisville PA, US Nicole C Goodwin - Pennington NJ, US
Compounds and pharmaceutical compositions comprising them are disclosed that may be useful for the treatment of diseases and disorders such as diabetes and obesity.
Piperdine-Based Inhibitors Of Sodium Glucose Co-Transporter 2 And Methods Of Their Use
Bryce Alden Harrison - Hamilton NJ, US Spencer David Kimball - East Windsor NJ, US Ross Mabon - Princeton NJ, US David Brent Rawlins - Morrisville PA, US
Compounds and pharmaceutical compositions comprising them are disclosed that may be useful for the treatment of diseases and disorders such as diabetes and obesity.
David J. Augeri - Princeton NJ, US Jeffrey Bagdanoff - Robbinsville NJ, US Lakmal W. Boteju - Kendall Park NJ, US Kenneth G. Carson - Princeton NJ, US Theodore C. Jessop - Lawrenceville NJ, US Spencer David Kimball - East Windsor NJ, US
Assignee:
Lexicon Pharmaceuticals, Inc. - The Woodlands TX
International Classification:
A61K 31/4164 C07D 233/64
US Classification:
514320, 5483361
Abstract:
Imidazole-based compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed. Particular compounds are of formula I:.
David J. Augeri - Princeton NJ, US Jeffrey Bagdanoff - Robbinsville NJ, US Lakmal W. Boteju - Kendall Park NJ, US Kenneth G. Carson - Princeton NJ, US Theodore C. Jessop - Lawrenceville NJ, US Spencer David Kimball - East Windsor NJ, US
Assignee:
Lexicon Pharmaceuticals, Inc. - The Woodlands TX
International Classification:
A61K 31/417 A61K 31/4174 A61K 31/4178 C07D 233/64
US Classification:
514397, 5483111, 514396
Abstract:
Methods of treating and managing ulcerative colitis, using imidazole-based compounds that inhibit S1P lyase, are disclosed.
Sulfanyl-Tetrahydropyran-Based Compounds And Methods Of Their Use
Bryce Alden Harrison - Hamilton NJ, US Spencer David Kimball - East Windsor NJ, US Ross Mabon - Princeton NJ, US David Brent Rawlins - Morrisville PA, US
Assignee:
Lexicon Pharmaceuticals, Inc. - The Woodlands TX
International Classification:
C07H 5/10 C07H 7/04 C07H 7/06
US Classification:
536 41, 536 176, 536 182
Abstract:
Sulfanyl-tetrahydropyran-based compounds, pharmaceutical compositions comprising them, and methods of their use for the treatment of diseases and disorders such as diabetes and obesity are disclosed.
Kelly has more cross-party support for Governor than Schmidt: 91% of Democrats plan to vote for Kelly, 18% of Republicans, and 49% of Independents, said Spencer Kimball, the executive director of Emerson College Polling.
Date: Nov 02, 2022
Category: U.S.
Source: Google
FDA Panel Endorses Updated Covid Boosters Targeting Omicron Subvariants
The FDA hopes the modified Covid-19 vaccines could start being administered early to mid-fall, when public health experts expect another wave of infection as immunity from previous vaccines and infections wane, the weather cools and individuals spend more time indoors, reports Spencer Kimball forCN
Date: Jul 01, 2022
Category: More news
Source: Google
Coronavirus live updates: Residents of three US states asked to defer domestic travel
Cuomo suggested he could sue if the administration did follow through. "I've sued the federal government a number of times over the years. I do not believe it's going to come to that on this," he said.Spencer Kimball
Date: Mar 28, 2020
Category: More news
Source: Google
Buttigieg surges to third place in new Iowa poll | TheHill
"The biggest surprise in this poll is Mayor Pete, last week we saw him inching up in our national poll, and now hes in double digits in Iowa, America is going to be asking who is Mayor Pete?Spencer Kimball, Director of the Emerson Poll, said.
Date: Mar 24, 2019
Category: U.S.
Source: Google
Is the blue wave crashing? 11 experts on Democrats’ chances in 2018.
Emersons Spencer Kimball notes that voter registration could be an important indicator to track as a sign of engagement ahead of the election. Florida, for example, has seen a slight pickup in GOP voters and a slight downtick in Democratic voters, he says. This may be an indication of under-the-
Date: Jun 07, 2018
Category: Headlines
Source: Google
Northern Virginia cab companies ask judge to halt Uber, Lyft operations
We built our businesses playing by the rules and by adhering to state law and local ordinances, said Spencer Kimball, the owner of Northern Virginia Checker Cab. This is not about competition. This is first and foremost about public safety and these companies ignoring the law to gain an unfair ad
Date: Jul 18, 2014
Category: U.S.
Source: Google
Forget 2016. The Pivotal Year In Politics May Be 2020
If the numbers hold, by 2020 Hispanic voters will represent at least 15 percent of the overall vote, says Spencer Kimball, a Republican strategist who teaches communication studies at Emerson College. And according to 2012 exit polls, more than 70 percent of Hispanic voters cast their ballots for Pr
Date: Jan 25, 2013
Category: U.S.
Source: Google
Elizabeth Warren Sees Bounce In Massachusetts Senate Poll
As pollster Spencer Kimball notes, the change is evidence that convention bumps can have effects beyond the top of the ticket. Democratic enthusiasm for the election appears to be up nationwide following the party's convention in Charlotte, where Warren spoke Wednesday. Brown, who has sought to dist