Stephanie S Yang

US Patent:

8425683, Apr 23, 2013

Filed:

Mar 8, 2010

Appl. No.:

12/719350

Inventors:

Eric Yang - Closter NJ, US
Marion Recane - Cypress TX, US
Stephanie H. Yang - Closter NJ, US

Assignee:

Acoustic Systems, Inc. - Houston TX
Acoustic Systems, Inc. - Nanuet NY

International Classification:

B08B 3/12
B08B 9/04

US Classification:

134 1, 134 8, 134 42

Abstract:

A method for tracking a scraper within a pipeline has the steps of moving the scraper along a path in the pipeline such that the scraper produces an acoustic signal, sensing the acoustic signal as produced by the scraper by at least a pair of acoustic sensors positioned in spaced relation along the pipeline, time-stamping the sensed acoustic signal, and calculating a location of the scraper based on the time-stamped acoustic signal. The acoustic signal can be a transient pressure wave produced by the movement of the scraper or a pressure signal produced by a mechanism positioned on the scraper.

US Patent:

20040156889, Aug 12, 2004

Filed:

Nov 26, 2003

Appl. No.:

10/723610

Inventors:

Ning Hu - San Gabriel CA, US
Gerard Jensen - Brea CA, US
Michele Sulivan - Arcadia CA, US
Stephanie Yang - Temple City CA, US

International Classification:

A61K009/127

US Classification:

424/450000

Abstract:

A method for encapsulation of pharmaceutical agents (e.g., antineoplastic agents) in liposomes is provided, having preferably a high drug:lipid ratio. Liposomes can be made by a process that loads the drug by an active mechanism using a transmembrane pH gradient. Using this technique, trapping efficiencies approach 100%. Drug:lipid ratios employed are higher than for older traditional liposome preparations, and the release rate of the drug from the liposomes is reduced. After loading, residual acid is quenched with a quenching agent that is base permeable at low temperatures. The residual aciditiy is thus reduced and chemical stability (e.g. against hydrolysis) is enhanced. The stability of both the liposome and the pharmaceutical agent is thus maintained, prior to administration. The pH gradient is, however, present when the liposome is administered in vivo because the quenching agent rapidly exits the liposome.

US Patent:

20040170677, Sep 2, 2004

Filed:

Nov 26, 2003

Appl. No.:

10/723431

Inventors:

Ning Hu - San Gabriel CA, US
Gerard Jensen - Brea CA, US
Michele Sulivan - Arcadia CA, US
Stephanie Yang - Temple City CA, US

International Classification:

A61K009/127

US Classification:

424/450000

Abstract:

A method for encapsulation of pharmaceutical agents (e.g., antineoplastic agents) in liposomes is provided, having preferably a high drug:lipid ratio. Liposomes can be made by a process that loads the drug by an active mechanism using a transmembrane pH gradient. Using this technique, trapping efficiencies approach 100%. Drug:lipid ratios employed are higher than for older traditional liposome preparations, and the release rate of the drug from the liposomes is reduced. After loading, residual acid is quenched with a quenching agent that is base permeable at low temperatures. The residual aciditiy is thus reduced and chemical stability (e.g. against hydrolysis) is enhanced. The stability of both the liposome and the pharmaceutical agent is thus maintained, prior to administration. The pH gradient is, however, present when the liposome is administered in vivo because the quenching agent rapidly exits the liposome.

US Patent:

20050238705, Oct 27, 2005

Filed:

Jan 14, 2005

Appl. No.:

11/035755

Inventors:

Ning Hu - San Gabriel CA, US
Gerard Jensen - Brea CA, US
Stephanie Yang - Temple City CA, US
Su-Ming Chiang - West Hills CA, US

International Classification:

A61K009/127

US Classification:

424450000

Abstract:

The invention provides lipid-based dispersion comprising comprising, a) phosphatidyl choline; b) an anionic phospholipid; optionally c) up to 1% cholesterol by weight of total lipids; and optionally d) a therapeutic agent; wherein the mean particle size measured by dynamic light scattering is less than 100 nm. The invention also provides pharmaceutical compositions comprising such a dispersion as well as methods of producing a therapeutic effect in a mammal comprising administering an effective amount of such a dispersion.

US Patent:

20080213345, Sep 4, 2008

Filed:

Sep 13, 2005

Appl. No.:

11/662048

Inventors:

Ning Hu - San Gabriel CA, US
Gerard M. Jensen - Brea CA, US
Craig Skenes - Lake Forest CA, US
Stephanie Yang - Temple City CA, US

Assignee:

GILEAD SCIENCES, INC. - Foster City CA

International Classification:

A61K 9/10
A61K 33/26
A61P 7/06

US Classification:

424450, 424646, 424647, 424648

Abstract:

The invention provides a method for delivery iron to an animal. This invention further provides a method for treating iron deficiency in an animal.

US Patent:

20090060998, Mar 5, 2009

Filed:

Jan 14, 2005

Appl. No.:

10/585915

Inventors:

Ning Hu - San Gabriel CA, US
Gerard M. Jensen - Brea CA, US
Stephanie Yang - Temple City CA, US

Assignee:

GILEAD SCIENCES, INC. - Foster City CA

International Classification:

A61K 9/10

US Classification:

424484

Abstract:

The invention provides lipid-based dispersion comprising, a) phosphatidyl choline; b) an anionic phospholipid; optionally c) up to 1% cholesterol by weight of total lipids; and optionally d) a therapeutic agent; wherein the mean particle size measured by dynamic light scattering is less than 100 nm. The invention also provides pharmaceutical compositions comprising such a dispersion as well as methods of producing a therapeutic effect in a mammal comprising administering an effective amount of such a dispersion.

US Patent:

20100119590, May 13, 2010

Filed:

Jul 13, 2009

Appl. No.:

12/501606

Inventors:

Ning Hu - San Gabriel CA, US
Gerard M. Jensen - Brea CA, US
Michele Sulivan - Arcadia CA, US
Stephanie Yang - Temple City CA, US

Assignee:

Gilead Sciences, Inc. - Foster City CA

International Classification:

A61K 9/127
A61K 31/55
A61P 35/00

US Classification:

424450, 51421402

Abstract:

A method for encapsulation of pharmaceutical agents (e.g., antineoplastic agents) in liposomes is provided, having preferably a high drug:lipid ratio. Liposomes can be made by a process that loads the drug by an active mechanism using a transmembrane pH gradient. Using this technique, trapping efficiencies approach 100%. Drug:lipid ratios employed are higher than for older traditional liposome preparations, and the release rate of the drug from the liposomes is reduced. After loading, residual acid is quenched with a quenching agent that is base permeable at low temperatures. The residual aciditiy is thus reduced and chemical stability (e.g. against hydrolysis) is enhanced. The stability of both the liposome and the pharmaceutical agent is thus maintained, prior to administration. The pH gradient is, however, present when the liposome is administered in vivo because the quenching agent rapidly exits the liposome.

US Patent:

20110093220, Apr 21, 2011

Filed:

Apr 15, 2010

Appl. No.:

12/760974

Inventors:

Eric Yang - Closter NJ, US
Marion Recane - Cypress TX, US
Stephanie H. Yang - Closter NJ, US

Assignee:

ACOUSTIC SYSTEMS,Inc. - Houston TX
ACOUSTIC SYSTEMS, Inc. - Nanuel NY

International Classification:

G01M 3/24

US Classification:

702 51

Abstract:

A system for detecting and locating leaks includes a pipeline, strain sensors positioned on the external surface of the pipeline, acoustic pressure sensors positioned at intervals along the pipeline, local processors connected to the strain sensors and acoustic pressure sensors, and a central processor connected to the local processors. The strain sensors measure a strain on the external surface of the pipeline indicative of changes in the pressure of the fluid within the pipeline. The acoustic pressure sensors sense acoustic signals within the pipline. Sensed acoustic pressure signals and sensed strain measurements are compared to each other and to stored profiles to detect and locate leaks.