Stephen F. Brady - Philadelphia PA, US James E. Bruce - Schwenksville PA, US Victor Garsky - Blue Bell PA, US Yueming Li - New York NY, US Mohinder Sardana - Lansdale PA, US Jules A. Shafer - Gwynedd Valley PA, US Xiaoting Tang - Lansdale PA, US
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 38/08
US Classification:
514 16, 435 71
Abstract:
The present invention provides synthetic β-secretase peptide substrates useful in various assays for measuring β-secretase activity. Antibodies that recognize the synthetic substrates and uses of the antibodies in various assays are disclosed. The herein disclosed peptide substrates are hydrolyzed at rates substantially faster than the attendant Swedish mutant APP from which the substrate sequences are derived.
Ming-Chih Crouthamel - Perkasie PA, US Stephen F. Brady - Philadelphia PA, US
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 31/195 C07C 229/00
US Classification:
514563, 562448
Abstract:
The present invention provides compounds that are inhibitors of the proteolytic activity of the enzyme β-secretase, pharmaceutically acceptable salts of the compounds, pharmaceutical compositions comprising the compounds, processes for making the compounds, and methods of using the compounds to treat Alzheimers disease.
Stephen F. Brady - Philadelphia PA, US James E. Bruce - Schwenksville PA, US Victor Garsky - Blue Bell PA, US Yueming Li - New York NY, US Mohinder Sardana - Lansdale PA, US Jules A. Shafer - Gwynedd Valley PA, US Xiaoting Tang - Lansdale PA, US
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
G01N 33/53
US Classification:
435 71, 435 72, 435 791, 435 792, 435 794, 436518
Abstract:
The present invention provides synthetic β-secretase peptide substrates useful in various assays for measuring β-secretase activity. Antibodies that recognize the synthetic substrates and uses of the antibodies in various assays are disclosed. The herein disclosed peptide substrates are hydrolyzed at rates substantially faster than the attendant Swedish mutant APP from which the substrate sequences are derived.
Conjugates Useful In The Treatment Of Prostate Cancer
Stephen Brady - Philadelphia PA, US Dong-Mei Feng - Blue Bell PA, US Victor Garsky - Blue Bell PA, US
Assignee:
Merck & Co., Inc.
International Classification:
A61K039/00 C07K007/06
US Classification:
424/185100, 530/409000, 530/329000
Abstract:
Chemical conjugates which comprise oligopeptides, having amino acid sequences that are selectively proteolytically cleaved by free prostate specific antigen (PSA) and known cytotoxic agents are disclosed. The conjugates of the invention are characterized by attachment of the cleavable oligopeptide to the oxygen atom at the 4-position on a vinca drug that has be desacetylated. Such conjugates are useful in the treatment of prostatic cancer and benign prostatic hypertrophy (BPH).
Conjugates Useful In The Treatment Of Prostate Cancer
Chemical conjugates which comprise oligopeptides, having amino acid sequences that are selectively proteolytically cleaved by free prostate specific antigen (PSA) and known cytotoxic agents are disclosed. The conjugates of the invention are characterized by attachment of the cleavable oligopeptide to the oxygen atom at the 4-position on a vinca drug that has be desacetylated. Such conjugates are useful in the treatment of prostatic cancer and benign prostatic hypertrophy (BPH).
Conjugates Useful In The Treatment Of Prostate Cancer
Stephen Brady - Philadelphia PA, US Dong-Mei Feng - Blue Bell PA, US Victor Garsky - Blue Bell PA, US
International Classification:
C07K 7/06 A61K 38/08
US Classification:
514017000, 530329000
Abstract:
Chemical conjugates which comprise oligopeptides, having amino acid sequences that are selectively proteolytically cleaved by free prostate specific antigen (PSA) and known cytotoxic agents are disclosed. The conjugates of the invention are characterized by attachment of the cleavable oligopeptide to the oxygen atom at the 4-position on a vinca drug that has be desacetylated. Such conjugates are useful in the treatment of prostatic cancer and benign prostatic hypertrophy (BPH).
Conjugates Useful In The Treatment Of Prostate Cancer
Stephen Brady - Philadelphia PA, US Dong-Mei Feng - Blue Bell PA, US Victor Garsky - Blue Bell PA, US
International Classification:
A61K 38/08 A61K 38/06 C07K 5/06 C07K 7/06
US Classification:
514017000, 514018000, 530329000, 530330000
Abstract:
Chemical conjugates which comprise oligopeptides, having amino acid sequences that are selectively proteolytically cleaved by free prostate specific antigen (PSA) and known cytotoxic agents are disclosed. The conjugates of the invention are characterized by attachment of the cleavable oligopeptide to the oxygen atom at the 4-position on a vinca drug that has be desacetylated. Such conjugates are useful in the treatment of prostatic cancer and benign prostatic hypertrophy (BPH).
Conjugates Useful In The Treatment Of Prostate Cancer
Stephen Brady - Philadelphia PA, US Dong-Mei Feng - Blue Bell PA, US Victor Garsky - Blue Bell PA, US
International Classification:
C07K 7/06 A61K 38/08
US Classification:
514017000, 530329000
Abstract:
Chemical conjugates which comprise oligopeptides, having amino acid sequences that are selectively proteolytically cleaved by free prostate specific antigen (PSA) and known cytotoxic agents are disclosed. The conjugates of the invention are characterized by attachment of the cleavable oligopeptide to the oxygen atom at the 4-position on a vinca drug that has be deacetylated. Such conjugates are useful in the treatment of prostatic cancer and benign prostatic hypertrophy (BPH).
Jul 2012 to Oct 2013 Digital Print OperatorPrint and Insertion Services Pennington, NJ Feb 2012 to Jul 2012 Equipment OperatorUnemployed
Nov 2010 to Feb 2012 Operations Manager - Print OperationsWachovia Corporation North Brunswick, NJ Apr 2003 to Nov 2010Prudential Securities / Wachovia Corp New York, NY Jul 1989 to Apr 2003 Equipment Operator - Print OperationsInstitutional Group Information Corp Great Neck, NY Mar 1988 to Jul 1989 Equipment Operator - Various OperationsE.F. Hutton New York, NY Oct 1986 to Mar 1988 Print Pool Operator - Print Operations
Education:
New York University New York NY Jan 1985 to Jun 1986 Certificate of Completion in Information Technology
2010 to 2000 Financial AnalystFinancial Controlling Malvern, PA 2008 to 2010 US Sales Support
Education:
Smeal College of Business 2004 to 2008 Bachelor of Science in FinanceThe Pennsylvania State University University Park, PA University of Alicante International Business and Spanish
Jul 2012 to Present Digital Print OperatorPrint and Insertion Services Pennington, NJ Feb 2012 to Jul 2012 Equipment OperatorUnemployed
Nov 2010 to Feb 2012 Operations Manager - Print OperationsWachovia Corporation North Brunswick, NJ Apr 2003 to Nov 2010Prudential Securities / Wachovia Corp New York, NY Jul 1989 to Apr 2003 Equipment Operator - Print OperationsInstitutional Group Information Corp Great Neck, NY Mar 1988 to Jul 1989 Equipment Operator - Various OperationsE.F. Hutton New York, NY Oct 1986 to Mar 1988 Print Pool Operator - Print Operations
Education:
New York University New York NY Jan 1985 to Jun 1986 Certificate of Completion in Information Technology
Jul 2012 to Present Digital Print OperatorBank of America Pennington, NJ Feb 2012 to Jul 2012 Machine OperatorWachovia Corporation North Brunswick, NJ Apr 2003 to Nov 2010 Operations Manager - Print OperationsPrudential Securities / Wachovia Corp New York, NY Jul 1989 to Apr 2003 Equipment Operator - Print OperationsInstitutional Group Information Corp Great Neck, NY Mar 1988 to Jul 1989 Equipment Operator - Various OperationsE.F. Hutton New York, NY Oct 1986 to Mar 1988 Print Pool Operator - Print Operations
Education:
New York University New York, NY Jan 1985 to Jun 1986 Certificate of Completion in Information Technology
Dr. Brady graduated from the Cornell University Weill Medical College in 1984. He works in Florence, SC and specializes in Cardiovascular Disease. Dr. Brady is affiliated with Carolinas Hospital System and Mcleod Regional Medical Center.
Dr. Brady graduated from the University of Pennsylvania School of Medicine in 1982. He works in Honolulu, HI and specializes in Internal Medicine. Dr. Brady is affiliated with Straub Clinic & Hospital and Wahiawa General Hospital.
Inverness Elementary School Baltimore MD 1960-1965, Grange Elementary School Baltimore MD 1962-1963, Essex Elementary School Essex MD 1965-1966, Stemmers Run Junior High School Baltimore MD 1966-1969
Were excited to announce this agreement that supports the advancement of amezalpat into a pivotal study and reinforces both Tempest and Roches shared commitment to delivering groundbreaking cancer treatments for patients, said Stephen Brady, president and chief executive officer of Tempest. Bas
Date: Oct 10, 2024
Category: Business
Source: Google
Cuomo targets power plant that closed after $110M subsidy by National Grid customers
created by Entergy's lawsuit led NRG to mothball the Dunkirk plant rather than convert it, Gaier said. In the meantime, National Grid has completed a major upgrade to its Western New York transmission system that made it possible to operate without Dunkirk, said Stephen Brady, speaking for the utility.
Date: Feb 13, 2016
Category: Business
Source: Google
In Buffalo, 'City of Good Neighbors' withstands wintry onslaught
didnt blow around as much. In New England -- where storms that deliver only a fraction of the snowfall can knock out the power for tens of thousands of residents for days on end -- high winds, shore flooding, and softer ground can lead to more outages, said National Grid spokesman Stephen Brady.
Bryce's secretary Stephen Brady wrote that she wanted an assurance from Rudd "that he will announce his appointment at the first possible opportunity to the House of Representatives on order to give the House the opportunity for whatever, if any, action it chooses to take."
One of seven children, Tassy has travelled widely, spending time in six different continents so far. She is the youngest sports ambassador for Cornwall. The other torchbearers at the UK's most westerly point will be Eric Smith, 76, Victoria Smith, 16, and Stephen Brady, 59.