Stephen E Brady

US Patent:

39636917, Jun 15, 1976

Filed:

Oct 7, 1974

Appl. No.:

5/512563

Inventors:

Carl H. Hoffman - Scotch Plains NJ
Harvey Schwam - Lafayette Hill PA
Stephen F. Brady - Meadowbrook PA
Martin Hichens - Somerville NJ
Ruth F. Nutt - Green Lane PA

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07C10352
C07G 700

US Classification:

2601125LH

Abstract:

Synthetic antigens related to luteinizing hormone-releasing hormone (hereinafter designated LH-RH) having the amino acid composition, pyroglutamyl-histidyl-tryptophanylseryl-tyrosyl-glycyl-leucyl-arginyl-prol yl-glycyl-poly-L-lysine (hereinafter designated pyroglu-his-trp-ser-tyr-glyleu-arg-pro-gly-poly-L-lys) and poly-L-lysyl-glutarylhistidyl-tryptophanyl-seryl-tyrosyl-glycyl-leucyl-arg inylprolyl-glycine amide (hereinafter designated poly-L-lysglutaryl-his-trp-ser-tyr-gly-leu-arg-pro-gly) are prepared by coupling the corresponding decapeptide with poly-L-lysine. The corresponding decapeptides are prepared by controlled stepwise procedures starting with individual amino acid components. These antigens have the property of inducing formation of antibodies to luteinizing hormone-releasing hormone (LH-RH) in animals.