Stephen M Carroll

US Patent:

60935731, Jul 25, 2000

Filed:

Jun 20, 1997

Appl. No.:

8/879565

Inventors:

Lesa J. Beamer - Santa Monica CA
Stephen F. Carroll - Walnut Creek CA
David Eisenberg - Los Angeles CA

Assignee:

XOMA - Berkeley CA
The Regents of the University of California - Oakland CA

International Classification:

G01N 3348

US Classification:

436 86

Abstract:

The present invention provides a crystallized Bactericidal Permeability-Increasing (BPI) protein; methods for x-ray diffraction analysis to provide x-ray diffraction patterns of sufficiently high resolution for three-dimensional structure determination of the protein, as well as methods for rational drug design, based on using amino acid sequence data and/or x-ray crystallography data provided on computer readable media, as analyzed on a computer system having suitable computer algorithms; and atomic coordinates are provided yielding structural information on the lipid binding and lipid transport protein family that includes BPI, LBP, CETP and PLTP.

Address:

131 Hillside Pl, Hot Springs, AR 71901

Phone:

5012621776

VIN:

2HKYF18737H534180

Make:

HONDA

Model:

PILOT

Year:

2007