Stephen W Chang

US Patent:

6818439, Nov 16, 2004

Filed:

Dec 30, 1997

Appl. No.:

09/001039

Inventors:

Douglas J. Jolly - Leucadia CA
Stephen Chang - Poway CA
James G. Respess - Pacific Beach CA
Nicholas J. DePolo - Solano Beach CA
David Chi-Tang Hsu - San Diego CA
Carlos E. Ibanez - San Diego CA
Judith Greengard - San Diego CA
Lee Will - Carlsbad CA

Assignee:

Chiron Corporation - Emeryville CA

International Classification:

C12N 15867

US Classification:

4353201, 4352351, 435 691, 435 696, 530350, 530384, 536 231, 536 235

Abstract:

Methods are provided for obtaining measurable levels of a protein, nucleic acid molecule, or enzymatic product in a bodily fluid or cells of a human, comprising the step of administering to a human a recombinant retroviral preparation having a titer on HT1080 cells of greater than 10 cfu/ml, wherein the recombinant retroviral preparation is capable of directing the expression of a protein, nucleic acid molecule, or enzyme which generates an enzymatic product, such that measurable levels of the protein, nucleic acid molecule, or enzymatic product may be obtained in the bodily fluid or cells of the human.

US Patent:

20020141974, Oct 3, 2002

Filed:

Jul 24, 2001

Appl. No.:

09/912679

Inventors:

Douglas Jolly - Leucadia CA, US
Stephen Chang - Poway CA, US
William Lee - Carlsbad CA, US
Kay Townsend - Encinitas CA, US
Joanne O'Dea - La Jolla CA, US

International Classification:

A61K048/00
A61K039/29

US Classification:

424/093200, 424/189100, 514/044000

Abstract:

The present invention provides methods of treating hepatitis C infections comprising the step of administering a vector construct which directs the expression of at least one immunogenic portion of a hepatitis C antigen, such that an immune response is generated. Also provided are vector constructs which direct the expression of at least one portion of a hepatitis C antigen, as well as recombinant viruses which carry such vector constructs.

US Patent:

20030003567, Jan 2, 2003

Filed:

Jul 24, 2002

Appl. No.:

10/205179

Inventors:

Jack Barber - San Diego CA, US
Douglas Jolly - La Jolla CA, US
James Respess - San Diego CA, US
Stephen Chang - San Diego CA, US

International Classification:

C12Q001/70
C12N007/00
C12N005/08

US Classification:

435/235100, 435/366000, 435/005000

Abstract:

The invention described herein allows the production of recombinant retroviruses (retroviral vector particles) from producer cells which are safer and of higher titer than normal. In addition, methods are provided for making helper cells which, when a recombinant retrovirus genome is introduced to make a producer line, produce particles that are targeted toward particular cell types. Methods are also provided for making recombinant retrovirus systems adapted to infect a particular cell type, such as a tumor, by binding the retrovirus or recombinant retrovirus in the particular cell type. Methods are also provided for producing recombinant retroviruses which integrate in a specific small number of places in the host genome, and for producing recombinant retroviruses from transgenic animals.

US Patent:

20030051259, Mar 13, 2003

Filed:

Jul 8, 2002

Appl. No.:

10/192431

Inventors:

Jack Barber - San Diego CA, US
Douglas Jolly - La Jolla CA, US
James Respess - San Diego CA, US
Stephen Chang - San Diego CA, US

International Classification:

C12N005/08
C12P021/00
C12N007/00

US Classification:

800/004000, 435/366000, 435/235100

Abstract:

The invention described herein allows the production of recombinant retroviruses (retroviral vector particles) from producer cells which are safer and of higher titre than normal. In addition, methods are provided for making helper cells which, when a recombinant retrovirus genome is introduced to make a producer line, produce particles that are targeted toward particular cell types. Methods are also provided for making recombinant retrovirus systems adapted to infect a particular cell type, such as a tumor, by binding the retrovirus or recombinant retrovirus in the particular cell type. Methods are also provided for producing recombinant retroviruses which integrate in a specific small number of places in the host genome, and for producing recombinant retroviruses from transgenic animals.

US Patent:

20030232035, Dec 18, 2003

Filed:

Jan 16, 2003

Appl. No.:

10/346880

Inventors:

Thomas Dubensky - Rancho Sante Fe CA, US
John Polo - San Diego CA, US
Carlos Ibanez - San Diego CA, US
Stephen Chang - San Diego CA, US
Douglas Jolly - Leucadia CA, US
David Driver - San Diego CA, US
Barbara Belli - San Diego CA, US

International Classification:

A01K067/00
C12Q001/68
A61K048/00
C12P021/02
C12N005/06
C12N015/86

US Classification:

424/093200, 435/006000, 435/456000, 435/325000, 435/320100, 800/008000

Abstract:

The present invention provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector initiation systems.

US Patent:

20040029278, Feb 12, 2004

Filed:

May 17, 2002

Appl. No.:

10/150407

Inventors:

Thomas Dubensky - Rancho Sante Fe CA, US
John Polo - San Diego CA, US
Carlos Ibanez - San Diego CA, US
Stephen Chang - San Diego CA, US
Douglas Jolly - Leucadia CA, US
David Driver - San Diego CA, US
Barbara Belli - San Diego CA, US

Assignee:

Chiron Corporation

International Classification:

C12N015/861
C12N015/86

US Classification:

435/456000, 435/320100, 435/325000

Abstract:

The present invention provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector initiation systems.

US Patent:

20100173412, Jul 8, 2010

Filed:

Aug 10, 2009

Appl. No.:

12/538494

Inventors:

John M. Polo - San Diego CA, US
Carlos E. Ibanez - San Diego CA, US
Stephen M.W. Chang - San Diego CA, US
Douglas J. Jolly - Leucadia CA, US
David A. Driver - San Diego CA, US
Barbara A. Belli - San Diego CA, US

International Classification:

C12N 5/071

US Classification:

435375

Abstract:

The present disclosure provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector initiation systems

US Patent:

56817460, Oct 28, 1997

Filed:

Dec 30, 1994

Appl. No.:

8/366851

Inventors:

Mordechai Bodner - San Diego CA
Nicholas J. De Polo - Solana Beach CA
Stephen Chang - Poway CA
David Chi-Tang Hsu - San Diego CA
James G. Respess - San Diego CA

Assignee:

Chiron Viagene, Inc.

International Classification:

C12N 500
C12N 1563
C07H 2104

US Classification:

435350

Abstract:

Retroviral vectors for directing expression of full length factor VIII in transduced host cells, plasmids encoding the same, and host cells transformed, transfected, or transduced therewith are disclosed. Also disclosed are retroviral particles comprising such retrovital vectors, as are methods for making such particles in suitable packaging cells. Retroviral particles so produced may be amphotropic, ecotropic, polytropic, or xenotropic; alternatively, they may comprise chimeric or hybrid envelope proteins to alter host range. Also described are retrovital particles comprising retroviral vectors for directing full length factor VIII expression which are complement resistant. Pharmaceutical compositions comprising retrovital particles of the invention are also disclosed, as are methods of treating mammals, particularly humans, afflicted with hemophilia.