Stephen M Chang

US Patent:

6818439, Nov 16, 2004

Filed:

Dec 30, 1997

Appl. No.:

09/001039

Inventors:

Douglas J. Jolly - Leucadia CA
Stephen Chang - Poway CA
James G. Respess - Pacific Beach CA
Nicholas J. DePolo - Solano Beach CA
David Chi-Tang Hsu - San Diego CA
Carlos E. Ibanez - San Diego CA
Judith Greengard - San Diego CA
Lee Will - Carlsbad CA

Assignee:

Chiron Corporation - Emeryville CA

International Classification:

C12N 15867

US Classification:

4353201, 4352351, 435 691, 435 696, 530350, 530384, 536 231, 536 235

Abstract:

Methods are provided for obtaining measurable levels of a protein, nucleic acid molecule, or enzymatic product in a bodily fluid or cells of a human, comprising the step of administering to a human a recombinant retroviral preparation having a titer on HT1080 cells of greater than 10 cfu/ml, wherein the recombinant retroviral preparation is capable of directing the expression of a protein, nucleic acid molecule, or enzyme which generates an enzymatic product, such that measurable levels of the protein, nucleic acid molecule, or enzymatic product may be obtained in the bodily fluid or cells of the human.

US Patent:

8260687, Sep 4, 2012

Filed:

Dec 31, 2007

Appl. No.:

11/967911

Inventors:

Stephen Chang - San Francisco CA, US
Robert Chatwani - Fremont CA, US
Daniel Burkhart - San Francisco CA, US

Assignee:

eBay Inc. - San Jose CA

International Classification:

G06Q 30/00

US Classification:

705 268, 705 271

Abstract:

In some example embodiments, a system and method are illustrated as including generating an item page that includes widget code and details related to an item for sale. Some example embodiments may include making the widget code available for retrieval from the item page.

US Patent:

20020141974, Oct 3, 2002

Filed:

Jul 24, 2001

Appl. No.:

09/912679

Inventors:

Douglas Jolly - Leucadia CA, US
Stephen Chang - Poway CA, US
William Lee - Carlsbad CA, US
Kay Townsend - Encinitas CA, US
Joanne O'Dea - La Jolla CA, US

International Classification:

A61K048/00
A61K039/29

US Classification:

424/093200, 424/189100, 514/044000

Abstract:

The present invention provides methods of treating hepatitis C infections comprising the step of administering a vector construct which directs the expression of at least one immunogenic portion of a hepatitis C antigen, such that an immune response is generated. Also provided are vector constructs which direct the expression of at least one portion of a hepatitis C antigen, as well as recombinant viruses which carry such vector constructs.

US Patent:

20030003567, Jan 2, 2003

Filed:

Jul 24, 2002

Appl. No.:

10/205179

Inventors:

Jack Barber - San Diego CA, US
Douglas Jolly - La Jolla CA, US
James Respess - San Diego CA, US
Stephen Chang - San Diego CA, US

International Classification:

C12Q001/70
C12N007/00
C12N005/08

US Classification:

435/235100, 435/366000, 435/005000

Abstract:

The invention described herein allows the production of recombinant retroviruses (retroviral vector particles) from producer cells which are safer and of higher titer than normal. In addition, methods are provided for making helper cells which, when a recombinant retrovirus genome is introduced to make a producer line, produce particles that are targeted toward particular cell types. Methods are also provided for making recombinant retrovirus systems adapted to infect a particular cell type, such as a tumor, by binding the retrovirus or recombinant retrovirus in the particular cell type. Methods are also provided for producing recombinant retroviruses which integrate in a specific small number of places in the host genome, and for producing recombinant retroviruses from transgenic animals.

US Patent:

20030051259, Mar 13, 2003

Filed:

Jul 8, 2002

Appl. No.:

10/192431

Inventors:

Jack Barber - San Diego CA, US
Douglas Jolly - La Jolla CA, US
James Respess - San Diego CA, US
Stephen Chang - San Diego CA, US

International Classification:

C12N005/08
C12P021/00
C12N007/00

US Classification:

800/004000, 435/366000, 435/235100

Abstract:

The invention described herein allows the production of recombinant retroviruses (retroviral vector particles) from producer cells which are safer and of higher titre than normal. In addition, methods are provided for making helper cells which, when a recombinant retrovirus genome is introduced to make a producer line, produce particles that are targeted toward particular cell types. Methods are also provided for making recombinant retrovirus systems adapted to infect a particular cell type, such as a tumor, by binding the retrovirus or recombinant retrovirus in the particular cell type. Methods are also provided for producing recombinant retroviruses which integrate in a specific small number of places in the host genome, and for producing recombinant retroviruses from transgenic animals.

US Patent:

20030232035, Dec 18, 2003

Filed:

Jan 16, 2003

Appl. No.:

10/346880

Inventors:

Thomas Dubensky - Rancho Sante Fe CA, US
John Polo - San Diego CA, US
Carlos Ibanez - San Diego CA, US
Stephen Chang - San Diego CA, US
Douglas Jolly - Leucadia CA, US
David Driver - San Diego CA, US
Barbara Belli - San Diego CA, US

International Classification:

A01K067/00
C12Q001/68
A61K048/00
C12P021/02
C12N005/06
C12N015/86

US Classification:

424/093200, 435/006000, 435/456000, 435/325000, 435/320100, 800/008000

Abstract:

The present invention provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector initiation systems.

US Patent:

20040029278, Feb 12, 2004

Filed:

May 17, 2002

Appl. No.:

10/150407

Inventors:

Thomas Dubensky - Rancho Sante Fe CA, US
John Polo - San Diego CA, US
Carlos Ibanez - San Diego CA, US
Stephen Chang - San Diego CA, US
Douglas Jolly - Leucadia CA, US
David Driver - San Diego CA, US
Barbara Belli - San Diego CA, US

Assignee:

Chiron Corporation

International Classification:

C12N015/861
C12N015/86

US Classification:

435/456000, 435/320100, 435/325000

Abstract:

The present invention provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector initiation systems.

US Patent:

20100173412, Jul 8, 2010

Filed:

Aug 10, 2009

Appl. No.:

12/538494

Inventors:

John M. Polo - San Diego CA, US
Carlos E. Ibanez - San Diego CA, US
Stephen M.W. Chang - San Diego CA, US
Douglas J. Jolly - Leucadia CA, US
David A. Driver - San Diego CA, US
Barbara A. Belli - San Diego CA, US

International Classification:

C12N 5/071

US Classification:

435375

Abstract:

The present disclosure provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector initiation systems