Stephen H Dailey

US Patent:

6593083, Jul 15, 2003

Filed:

Oct 17, 2000

Appl. No.:

09/690359

Inventors:

Sushil G. Devare - Northbrook IL 60062
Suresh M. Desai - Libertyville IL 60048
James M. Casey - Zion IL 60099
Stephen H. Dailey - Vernon Hills IL 60061
George J. Dawson - Libertyville IL 60048
Robin A. Gutierrez - Gumee IL 60031
Richard R. Lesniewski - Kenosha WI 53142
James L. Stewart - Gumee IL 60031
Kevin R. Rupprecht - Grayslake IL 60030

International Classification:

C12Q 170

US Classification:

435 5, 435 71, 435 691, 435 713, 436536

Abstract:

Unique recombinant antigens representing distinct antigenic regions of the Hepatitis C Virus (HCV) genome which can be used as reagents for the detection of antibodies and antigen in body fluids from individuals exposed to HCV. The present invention also provides an assay for detecting the presence of an antibody to an HCV antigen in a sample by contacting the sample with the recombinant antigens. Preferred assay formats include a screening assay, a confirmatory assay, a competition or neutralization assay and an immunodot assay.

US Patent:

61721891, Jan 9, 2001

Filed:

Jun 2, 1997

Appl. No.:

8/867611

Inventors:

Sushil G. Devare - Northbrook IL
Suresh M. Desai - Libertyville IL
James M. Casey - Zion IL
Stephen H. Dailey - Vernon Hills IL
George J. Dawson - Libertyville IL
Robin A. Gutierrez - Gurnee IL
Richard R. Lesniewski - Kenosha WI
James L. Stewart - Gurnee IL
Kevin R. Rupprecht - Grayslake IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 3804
A61K 3929
C07K 500
C12N 1501

US Classification:

530350

Abstract:

The present invention provides unique recombinant antigens representing distinct antigenic regions of the Hepatitis C Virus (HCV) genome which can be used as reagents for the detection of antibodies and antigen in body fluids from individuals exposed to HCV. The present invention also provides an assay for detecting the presence of an antibody to an HCV antigen in a sample by contacting the sample with the recombinant antigens. Preferred assay formats include a screening assay, a confirmatory assay, a competition or neutralization assay and an immunodot assay.

US Patent:

53087500, May 3, 1994

Filed:

Aug 21, 1991

Appl. No.:

7/748292

Inventors:

Smriti U. Mehta - Libertyville IL
Jill E. Johnson - Waukegan IL
Stephen H. Dailey - Vernon Hills IL
Suresh M. Desai - Libertyville IL
Sushil G. Devare - Northbrook IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C12N 500
C12Q 170

US Classification:

435 5

Abstract:

Monoclonal antibodies which specifically bind to Hepatitis C Virus (HCV) E2/NS1 antigen. Also provided are hybridoma cell lines which secrete these monoclonal antibodies, methods for using these monoclonal antibodies, and assay kits for assays which contain these monoclonal antibodies.