Stephen Dotson

US Patent:

20100027008, Feb 4, 2010

Filed:

Oct 24, 2005

Appl. No.:

11/666046

Inventors:

Daryl J. Bornhop - Nashville TN, US
Stephen Dotson - Nashville TN, US
Brian O. Bachmann - Nashville TN, US

Assignee:

VANDERBILT UNIVERSITY - Nashville TN

International Classification:

G01J 4/00

US Classification:

356364

Abstract:

A polarimetry technique for measuring optical activity that is particularly suited for high throughput screening employs a chip or substrate () having one or more microfluidic channels () formed therein. A polarized laser beam () is directed onto optically active samples that are disposed in the channels. The incident laser beam interacts with the optically active molecules in the sample, which slightly alter the polarization or the loser beam as it passes multiple times through the sample. Interference fringe patters () are generated by the interaction of the laser beam with the sample and the channel walls. A photodetector () is positioned to receive the interference fringe patterns and generate an output signal that is input to a computer or other analyzer () for analyzing the signal and determining the rotation of plane polarized light by optically active material in the channel from polarization rotation calculations.

US Patent:

20150057949, Feb 26, 2015

Filed:

Mar 15, 2013

Appl. No.:

14/389504

Inventors:

- Nashville TN, US
William E. Rich - Nashville TN, US
Stephen Dotson - Nashville TN, US
Kirk C. Odencrantz - Boise ID, US
Fei Shen - San Jose CA, US
Richard Isaacs - Nashville TN, US

International Classification:

G01N 21/45
G01J 9/02

US Classification:

702 32

Abstract:

Methods and systems for improved chemical event detection from back scattering interferometry fringe data provide sensitive detection of a chemical event by more selectively analyzing fringe shift data.