Jin Cheng - San Jose CA, US Stephen Dugan - Berkeley CA, US Gordon Stewart - San Francisco CA, US Gina Zhang - Calabasas CA, US Nancy Kirsten - Tucson AZ, US Paul Consigny - San Jose CA, US Christopher Feezor - San Jose CA, US Gene Park - Santa Rosa CA, US Wouter Roorda - Palo Alto CA, US Syed F. A. Hossainy - Fremont CA, US
Assignee:
Abbot Cardiovascular Systems Inc. - Santa Clara CA
International Classification:
A61F 2/02
US Classification:
424423
Abstract:
A drug-delivery system is provided including at least 100 μg of everolimus and clobetasol, such that the ratio of everolimus to clobetasol is at least 10:1 (w/w) or the amount of everolimus by weight is at least 10 times more than clobetasol. The system can be a stent. Also provided a method of treating restenosis or vulnerable plaque of a blood vessel, the method includes locally administering to a patient a first drug selected from a group consisting of rapamycin (sirolimus), Biolimus A9, deforolimus, AP23572, tacrolimus, temsirolimus, pimecrolimus, zotarolimus (ABT-578), 40-O-(2-hydroxy)ethylrapamycin (everolimus), 40-O-(3-hydroxy)propylrapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethylrapamycin, 40-O-tetrazolylrapamycin and 40-epi-(N1-tetrazolyl)rapamycin, and locally administering to a patient a second drug consisting of clobetasol, wherein the minimum amount of the first drug that is locally administered is 100 μg, and wherein the ratio of the first drug to the second drug is, for example, 10:1 to 100:1 (w/w).
Anti-Proliferative And Anti-Inflammatory Agent Combination For Treatment Of Vascular Disorders
Gordon Stewart - San Francisco CA, US Gina Zhang - Fremont CA, US Nancy Kirsten - San Carlos CA, US Paul Consigny - San Jose CA, US Stephen Dugan - San Francisco CA, US Gene Park - Oakland CA, US Christopher Feezor - San Jose CA, US Wouter Roorda - Palo Alto CA, US Syed Faiyaz Ahmed Hossainy - Fremont CA, US
Assignee:
Abbott Cardiovascular Systems Inc. - Santa Clara CA
International Classification:
A61F 13/00 A61F 2/00
US Classification:
424422, 424423
Abstract:
Drug-delivery systems such as drug-delivery stents having an anti-proliferative agent such as everolimus and an anti-flammatory agent such as clobetasol are provided. Also disclosed are methods of treating a vascular impairment such as restenosis or vulnerable plaque.
Anti-Proliferative And Anti-Inflammatory Agent Combination For Treatment Of Vascular Disorders
Gordon Stewart - San Francisco CA, US Gina Zhang - Fremont CA, US Nancy Kristen - San Carlos CA, US Paul Consigny - San Jose CA, US Stephen Dugan - San Francisco CA, US Gene Park - Oakland CA, US Christopher Feezor - San Jose CA, US Wouter Roorda - Palo Alto CA, US Syed Hossainy - Fremont CA, US
International Classification:
A61K 31/4745 A61F 2/00
US Classification:
424423000, 514291000
Abstract:
Drug-delivery systems such as drug-delivery stents having an anti-proliferative agent such as everolimus and an anti-flammatory agent such as clobetasol are provided. Also disclosed are methods of treating a vascular impairment such as restenosis or vulnerable plaque.
Drug-delivery systems such as drug-delivery stents having an anti-proliferative agent such as everolimus and an anti-flammatory agent such as clobetasol are provided. Also disclosed are methods of treating a vascular impairment such as restenosis or vulnerable plaque
Anti-Proliferative And Anti-Inflammatory Agent Combination For Treatment Of Vascular Disorders With An Implantable Medical Device
Advanced Cardiovascular Systems, Inc. - Santa Clara CA
International Classification:
A61F 2/02
US Classification:
424423
Abstract:
Drug-delivery systems such as drug-delivery stents having an anti-proliferative agent such as everolimus and an anti-inflammatory agent such as clobetasol are provided. Also disclosed are methods of treating a vascular impairment such as restenosis or vulnerable plaque.
Systems, Devices, And Methods For Tracking Abdominal Orientation And Activity For Treatment And Prevention Of Pressure Sores
Methods and devices for monitoring and changing the physical orientation of an individual are provided. A method includes providing a wearable device that monitors the physical orientation of an individual, monitoring the physical orientation over time using the wearable device, and issuing an alert from the wearable device to change the physical orientation by a prescribed amount when the individual has maintained the physical orientation for a duration exceeding a maximum length. The wearable device is optionally configured to issue subsequent alerts upon determining that the physical orientation has not changed following the duration. The alerts are optionally of varying natures and issued to, for example, the individual, people nearby, and/or caregivers outside the individual's room.
Systems, Devices, And Methods For Tracking Abdominal Orientation And Activity For Prevention Of Poor Respiratory Disease Outcomes
The disclosed apparatus, systems and methods relate to tracking abdominal orientation and activity for purposes of preventing or treating conditions of pregnancy, respiratory diseases or other types of medical conditions. In certain specific embodiments, the system, device, or method relates to identifying abdominal or sleep position orientation risk values, calculating and updating a cumulative risk value, comparing the cumulative risk value to a threshold, and outputting a warning when the cumulative risk value crosses the threshold.