Stephen M Hash

US Patent:

20020028208, Mar 7, 2002

Filed:

Apr 30, 1999

Appl. No.:

09/303510

Inventors:

ELLEN W. COLLISSON - COLLEGE STATION TX, US
STEPHEN M. HASH - AUSTIN TX, US
INSOO CHOI - COLLEGE STATION TX, US

International Classification:

A61K039/21
C07H021/04

US Classification:

424/188100, 536/023500

Abstract:

The present invention provides isolated and purified DNA encoding feline CD80 (B7-1) ligand, feline CD86 (B7-2) ligand, feline CD28 receptor, or feline CTLA-4 (CD152) receptor, as well as vectors comprising nucleic acid encoding feline CD80, feline CD86, feline CD28, or feline CTLA-4. The present invention provides a host cells transformed with CD80-encoding vectors, CD86-encoding vectors, CD28-encoding vectors, or CTLA-4-encoding vectors. The invention provides polypeptides encoded by the nucleic acid of feline CD80, feline CD86, feline CD28, or feline CTLA-4. The present invention provides a vaccine comprising an effective amount of polypeptides encoded by the nucleic acid of feline CD80, feline CD86, feline CD28, or feline CTLA-4. The present invention also provides vaccines which further comprise immunogens derived from pathogens. The invention provides for vaccines capable of enhancing an immune response. The invention also provides for vaccines capable of suppressing and immune response.

US Patent:

20080145382, Jun 19, 2008

Filed:

Aug 17, 2007

Appl. No.:

11/840708

Inventors:

Ellen W. Collisson - College Station TX, US
Stephen M. Hash - Austin TX, US
Insoo Choi - Seoul, KR
Barbara J. Winslow - Del Mar CA, US
Mark D. Cochran - Carlsbad CA, US

International Classification:

A61K 48/00
C12N 7/01
A61K 39/12
A61P 43/00
A61P 35/00

US Classification:

4241991, 4352351, 424 932

Abstract:

The present invention involves a recombinant virus which comprises at least one foreign nucleic acid inserted within a non-essential region of the viral genome of a virus, wherein each such foreign nucleic acid encodes a protein. The protein which is encoded is selected from the groups consisting of a feline CD28 protein or an immunogenic portion thereof, a feline cD80 protein or an immunogenic portion thereof, a feline CD86 protein or an immunogenic portion thereof, or a feline CTLA-4 protein or an immunogenic portion thereof. The protein is capable of being expressed when the recombinant virus is introduced into an appropriate host. The present invention also involves a recombinant virus further comprising a foreign nucleic acid encoding an immunogen derived from a pathogen. The present invention also comprises recombinant viruses which are capable of enhancing an immune response in a feline. The present invention also comprises recombinant viruses which are capable of suppressing an immune response in a feline.

US Patent:

20130295133, Nov 7, 2013

Filed:

Oct 12, 2012

Appl. No.:

13/650553

Inventors:

Ellen W. Collisson - Upland CA, US
In-Soo Choi - Seoul, KR
Stephen M. Hash - Austin TX, US

Assignee:

THE TEXAS A&M UNIVERSITY SYSTEM - College Station TX
INTERVET INC. - Summit NJ

International Classification:

A61K 39/275

US Classification:

4241991, 4352351, 530350, 4353201, 43525233, 4352542, 435365, 435353, 435361

Abstract:

The present invention involves a recombinant virus which comprises at least one foreign nucleic acid inserted within a non-essential region of the viral genome of a virus, wherein each such foreign nucleic acid encodes a protein. The protein which is encoded is selected from the groups consisting of a feline CD28 protein or an immunogenic portion thereof, a feline cD80 protein or an immunogenic portion thereof, a feline CD86 protein or an immunogenic portion thereof, or a feline CTLA-4 protein or an immunogenic portion thereof. The protein is capable of being expressed when the recombinant virus is introduced into an appropriate host. The present invention also involves a recombinant virus further comprising a foreign nucleic acid encoding an immunogen derived from a pathogen. The present invention also comprises recombinant viruses which are capable of enhancing an immune response in a feline. The present invention also comprises recombinant viruses which are capable of suppressing an immune response in a feline.

US Patent:

7279168, Oct 9, 2007

Filed:

Apr 30, 1999

Appl. No.:

09/303040

Inventors:

Barbara J. Winslow - Del Mar CA, US
Mark D. Cochran - Carlsbad CA, US
Stephen Hash - Austin TX, US
Insoo Choi - Seoul, KR
Ellen Collisson - College Station TX, US

Assignee:

Texas A & M University System - College Station TX
Schering-Plough Animal Health Corporation - Summit NJ

International Classification:

A61K 39/00
A61K 39/02
A61K 39/12
A61K 39/21
A61K 39/205

US Classification:

4242071, 4241991, 4242041, 4242241, 4242291, 4242341

Abstract:

The present invention involves a recombinant virus which comprises at least one foreign nucleic acid inserted within a non-essential region of the viral genome of a virus, wherein each such foreign nucleic acid encodes a protein. The protein which is encoded is selected from the groups consisting of a feline CD28 protein or an immunogenic portion thereof, a feline cD80 protein or an immunogenic portion thereof, a feline CD86 protein or an immunogenic portion thereof, or a feline CTLA-4 protein or an immunogenic portion thereof. The protein is capable of being expressed when the recombinant virus is introduced into an appropiate host. The present invention also involves a recombinant virus further comprising a foreign nucleic acid encoding an immunogen derived from a pathogen. The present invention also comprises recombinant viruses which are capable of enhancing an immune response in a feline. The present invention also comprises recombinant viruses which are capable of suppressing an immune respons in a feline.

Address:

5943 Lomita Verde Cir, Austin, TX 78749

VIN:

5TEMU52N87Z360185

Make:

TOYOTA

Model:

TACOMA

Year:

2007