Stephen B. Howell - Del Mar CA Xinjian Lin - San Diego CA Dennis P. Gately - San Diego CA
Assignee:
Research Development Foundation - Carson City NV
International Classification:
C12Q 168
US Classification:
435 6, 435 29, 435366, 435371
Abstract:
The present invention features a novel cellular injury reporter system in which a chimeric gene containing the GADD153 promoter linked to the coding region of an enhanced green fluorescent protein (EGFP) gene was stably integrated into the genome of carcinoma cells. Activation of the GADD153 promoter was quantified using flow cytometric measurement of EGFP expression following drug exposure. This reporter system is suitable for high. throughput in vitro and in vivo screening for agents capable of producing cytotoxicity via a wide variety of different mechanisms, and can be utilized to investigate the relative potency of structurally related DNA adducts.
Timothy Cheng - Toronto, CA Stephen Howell - Del Mar CA, US Gerald Manorek - San Diego CA, US Charles Berry - San Diego CA, US Goli Samimi - Los Angeles CA, US
International Classification:
C12Q 1/68
US Classification:
435006000
Abstract:
The present invention relates generally to the fields of molecular biology and medicine. More particularly, it concerns cancer treatments and the identification and use of markers for cancer resistance to a platinum-drug based therapy therapy. In certain embodiments, the present invention provides diagnostic and/or prognostic methods involving a collection of differentially expressed genes that may be used to identify cisplatin resistance in human ovarian cancer.
Dna Sequences Encoding Coleoptera Luciferase Activity
Marlene DeLuca McElroy - late of La Jolla CA Donald Raymond Helinski - La Jolla CA Keith Vernon Wood - San Diego CA Jeffrey Roux De Wet - Menlo Park CA David Wing Ow - San Francisco CA Stephen Herbert Howell - Del Mar CA
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
C12N 121 C12N 510 C12N 1553 C12N 902
US Classification:
435 697
Abstract:
DNA compositions and methods of constructing and using the same consisting of DNA sequences encoding luciferase activity, or DNA sequences encoding hybrid molecules exhibiting luciferase activity and a second biological activity that are useful in performing biological assays.
Multivesicular Liposomes Having A Biologically Active Substance Encapsulated Therein In The Presence Of A Hydrochloride
Sinil Kim - Solana Beach CA Stephen B. Howell - Del Mar CA
Assignee:
DepoTech Corporation - La Jolla CA
International Classification:
A61K 9127
US Classification:
424450
Abstract:
Disclosed are multivesicular liposomes containing biologically active substances, the multivesicular liposomes having defined size distribution, adjustable average size, adjustable internal chamber size and number, and a modulated rate of the biologically active substance in contrast to the previous art. The process comprises dissolving a lipid component in volatile organic solvents, adding an immiscible aqueous component containing at least one biologically active substance to be encapsulated, and adding to either or both the organic solvents and the lipid component, a hydrochloride effective to control the release rate of the biologically active substance from the multivesicular liposome, making a water-in-oil emulsion from the two components, immersing the emulsion into a second aqueous component, dividing the emulsion into small solvent spherules which contain even smaller aqueous chambers, and then removing the solvents to give an aqueous suspension of multivesicular liposomes encapsulating biologically active substances.
Multivesicular Liposomes With Controlled Release Of Active Agents Encapsulated In The Presence Of A Hydrochloride
Sinil Kim - Solana Beach CA Stephen B. Howell - Del Mar CA
Assignee:
SkyePharma Inc. - San Diego CA
International Classification:
A61K 9127
US Classification:
424450
Abstract:
Disclosed are multivesicular liposomes containing biologically active substances, and having defined size distribution, adjustable average size, adjustable internal chamber size and number, and a modulated release of the biologically active substance. The liposomes are made by a process comprising dissolving a lipid component in volatile organic solvents, adding an immiscible aqueous component containing at least one biologically active substance to be encapsulated, and adding to either or both the organic solvents and the lipid component, a hydrochloride effective to control the release rate of the biologically active substance from the multivesicular liposome. A water-in-oil emulsion is made from the two components, the emulsion is immersed into a second aqueous component, and then divided into small solvent spherules which contain even smaller aqueous chambers. The solvents arc finally removed to give an aqueous suspension of multivesicular liposomes encapsulating biologically active substances.
Marlene D. McElroy - late of La Jolla CA W. D. McElroy - San Diego CA Donald R. Helinski - La Jolla CA Keith V. Wood - San Diego CA Jeffrey R. De Wet - Menlo Park CA David W. Ow - San Francisco CA Stephen H. Howell - Del Mar CA
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
C12N 902 C12N 1553 C12N 1563
US Classification:
135189
Abstract:
A method is disclosed for producing a protein which expresses bioluminescence activity which involves combining two polydeoxyribonucleotides, one containing a continuous sequence of codons encoding a polypeptide which comprises a single covalently bonded molecular structure and which catalyzes the oxidation of insect luciferin to yield light and the other which causes DNA transcription, and obtaining the polypeptide by transcription and subsequent translation. The insect luciferin is derived from bioluminescent insect, preferably Diptera and Coleoptera (fireflies and beetles). Hybrid proteins are similarly formed by inclusion of an additional polydeoxyribonucleotide encoding for a second polypeptide such that their respective polypeptide-encoding reading frames form a continuous reading frame. Also disclosed is a method for quantitatively assaying a fluid for the presence of an unknown quantity of antigen using the hybrid proteins bonded to antibody directed against the antigen, determining luminescence after reaction of the antibody and antigen, and determining the amount of the antigens by comparison of the determined luminescence with the luminescence previously measured under equivalent conditions for equivalent hybrid proteins reacted under equivalent conditions with known amounts of the antigen.
Sinil Kim - Solana Beach CA Stephen B. Howell - Del Mar CA
Assignee:
DepoTech Corporation - San Diego CA
International Classification:
A61K 9127
US Classification:
424450
Abstract:
A method for ameliorating a neurological disorder in a human by administration to the cerebrospinal fluid (CSF) of a therapeutic agent in a dispersion system which allows the therapeutic agent to persist in the cerebro-ventricular space.
Deputy Commandant of Information
Psychological Operations Officer
United States Marine Corps Aug 2013 - Jul 2017
Psychological Operations
United States Marine Corps Aug 2013 - Jul 2017
Officer
Education:
Liberty University 2014 - 2015
Masters, Human Services
The University of Memphis 2007 - 2009
Bachelors, Psychology, History
Skills:
Military Experience Military Operations Operational Planning Marine Corps Military Training Military Counterinsurgency Combat Force Protection Dod Afghanistan Security Clearance Command National Security Weapons Military Logistics Tactics Military Liaison Organizational Leadership Leadership Counterterrorism Physical Security Defense Leadership Development Exercises Weapons Training Intelligence Analysis Marksmanship Security Operations Weapons Handling Firearms Logistics Management Personnel Supervision Readiness Infantry Tactics Top Secret Intelligence Information Assurance Nato Interagency Coordination Joint Military Operations Active Dod Secret Clearance Briefing Personnel Security Government Program Management
3855 Health Sciences Dr, La Jolla, CA 92093 8588221110 (Phone), 8588221111 (Fax)
MOORES UCSD CANCER CENTER 3855 Health Sciences Dr Suite 987, La Jolla, CA 92093 8588226600 (Phone), 8588226352 (Fax)
Certifications:
Internal Medicine, 1973 Medical Oncology, 1977
Awards:
Healthgrades Honor Roll
Languages:
English
Education:
Medical School Harvard Medical School Graduated: 1970 Medical School Massachusetts General Hospital Graduated: 1970 Medical School U Calif Hosps Graduated: 1970 Medical School Sidney Farber Cancer Inst Graduated: 1970
Barad & Howell Mds 8120 Timberlake Way STE 112, Sacramento, CA 95823 9166897370 (phone), 9166885610 (fax)
Education:
Medical School Northwestern University Feinberg School of Medicine Graduated: 1981
Procedures:
Hip Replacement Joint Arthroscopy Knee Arthroscopy Knee Replacement Arthrocentesis Hip/Femur Fractures and Dislocations Lower Arm/Elbow/Wrist Fractures and Dislocations Lower Leg/Ankle Fractures and Dislocations Shoulder Arthroscopy Shoulder Surgery
Conditions:
Osteoarthritis Fractures, Dislocations, Derangement, and Sprains Internal Derangement of Knee Internal Derangement of Knee Cartilage Internal Derangement of Knee Ligaments
Languages:
English Russian Spanish
Description:
Dr. Howell graduated from the Northwestern University Feinberg School of Medicine in 1981. He works in Sacramento, CA and specializes in Orthopaedic Surgery and Orthopedic Sports Medicine. Dr. Howell is affiliated with Methodist Hospital Sacramento.
UCSD Medical GroupUCSD Moores Cancer Center 3855 Health Sciences Dr, La Jolla, CA 92093 8588226100 (phone), 8582461847 (fax)
Education:
Medical School Harvard Medical School Graduated: 1970
Conditions:
Bladder Cancer Hodgkin's Lymphoma Kidney Cancer Lung Cancer Malignant Neoplasm of Colon
Languages:
English
Description:
Dr. Howell graduated from the Harvard Medical School in 1970. He works in La Jolla, CA and specializes in Hematology/Oncology. Dr. Howell is affiliated with UCSD Medical Center and UCSD Thornton Hospital.
University Health AssociatesWest Virginia University Anesthesiology 1 Medical Ctr Dr, Morgantown, WV 26506 3045984122 (phone), 3045984930 (fax)
Education:
Medical School West Virginia University School of Medicine Graduated: 2003
Languages:
English
Description:
Dr. Howell graduated from the West Virginia University School of Medicine in 2003. He works in Morgantown, WV and specializes in Anesthesiology. Dr. Howell is affiliated with West Virginia Ruby Memorial Hospital.
3855 Health Sciences Dr, La Jolla, CA 92093 Limited To Official University Duties On, La Jolla, CA 92093
Education:
Harvard Medical School - Doctor of Medicine Dana-Farber Cancer Institute - Fellowship - Oncology (Internal Medicine) University of California-Davis Medical Center - Residency - Family Medicine Massachusetts General Hospital - Residency - Family Medicine
Board certifications:
American Board of Internal Medicine Certification in Internal Medicine American Board of Internal Medicine Sub-certificate in Oncology (Internal Medicine)
Oxford, OxfordshireDirector Market Development EU at Checkpoint Syste... Past: Global Product Manager - RFID Systems & Labels at Checkpoint Systems, Senior Supply Chain... I have been active withing the RFID industry since 2004 and was a participant in the standards creation process in ETSI (TG34) when the first release of the EN... I have been active withing the RFID industry since 2004 and was a participant in the standards creation process in ETSI (TG34) when the first release of the EN 302-208 regulation was drafted. I am an active member of EPCglobal/GS1 and have been involved in most of the major European RFID projects...