Stephen J Karr

US Patent:

6861510, Mar 1, 2005

Filed:

Jun 6, 1995

Appl. No.:

08/465917

Inventors:

Philip C. Gevas - Honolulu HI, US
Stephen L. Karr - Davis CA, US
Stephen Grimes - Davis CA, US
Richard L. Littenberg - Kai Lua HI, US

Assignee:

Aphton Corporation - Woodland CA

International Classification:

C07K016/00
C12P021/08
A61K039/395
A61K039/40
A61K039/42

US Classification:

5303881, 53038824, 53038815, 530386, 5303871, 530326, 530327, 530328, 530329, 530330, 4241841, 4241301, 4241411, 4241421

Abstract:

Immmunogenic compositions useful for the treatment of ulcers or tumors whose growth is dependent on or stimulated by gastrin hormones are disclosed. The immunogenic compositions induce antibodies in a subject which selectively neutralize the specific hormones. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are disclosed. A method of reversing the inventive treatments by neutralizing the antibodies induced in vivo is also disclosed.

US Patent:

20050025770, Feb 3, 2005

Filed:

Jan 20, 2004

Appl. No.:

10/762226

Inventors:

Philip Gevas - Honolulu HI, US
Stephen Karr - Davis CA, US
Stephen Grimes - Davis CA, US
Dov Michaeli - Larkspur CA, US
Susan Watson - Nottingham, GB

International Classification:

A61K039/395

US Classification:

424155100

Abstract:

A method of treating gastrointestinal cancers dependent on the prohormones amidated gastrin-and glycine extended G-, comprising the administration to the patient of an anti-gastrin immunogen which induces antibodies which bind and neutralize amidated and glycine-extended gastrin-

US Patent:

58661280, Feb 2, 1999

Filed:

Jun 5, 1995

Appl. No.:

8/465546

Inventors:

Philip C. Gevas - Honolulu HI
Stephen L. Karr - Davis CA
Stephen Grimes - Davis CA
Richard L. Littenberg - Kai Lua HI

Assignee:

Aphton Corporation - Woodland CA

International Classification:

A61K 3900
A61K 3938
A61K 3800
C07K 500

US Classification:

4241841

Abstract:

Immunogenic compositions useful for the treatment or prevention of gastric or duodenal ulcer disease are disclosed. The immunogenic compositions effectively operate by inducing antibodies in a subject which selectively neutralize specific peptide gastric hormones and inhibit the binding of the hormones to physiological receptors thus limiting the secretion of stomach acid. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are also disclosed.

US Patent:

54684943, Nov 21, 1995

Filed:

Nov 12, 1993

Appl. No.:

8/151219

Inventors:

Philip C. Gevas - Honolulu HI
Stephen Grimes - Davis CA
Stephen L. Karr - Davis CA
Dov Michaeli - Larkspur CA
Robert Scibienski - Woodland CA

Assignee:

Aphton Corp. - Woodland CA

International Classification:

A61K 39385
C07K 706
C07K 708
C07K 1706

US Classification:

42419511

Abstract:

An improved immunogenic composition against human gastrin 17 comprising the peptide pGlu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Ser-Ser-Pro-Pro-Pro-Pro-Cys (SEQ ID NO. : 1) coupled to an immunogenic carrier and pharmaceutical compositions containing the same.

US Patent:

56076762, Mar 4, 1997

Filed:

Jul 22, 1991

Appl. No.:

7/721638

Inventors:

Philip C. Gevas - Honolulu HI
Stephen L. Karr - Davis CA
Stephen Grimes - Davis CA
Richard L. Littenberg - Kai Lua HI

Assignee:

Aphton Corporation - Woodland CA

International Classification:

C07K 500
A61K 3900
A61K 39385
A61K 3800

US Classification:

42419711

Abstract:

Immunogenic compositions useful for the treatment of ulcers or tumors whose growth is dependent on or stimulated by gastrin hormones are disclosed. The immunogenic compositions induce antibodies in a subject which selectively neutralize the specific hormones. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are disclosed. A method of reversing the inventive treatments by neutralizing the antibodies induced in vivo is also disclosed.

US Patent:

57859701, Jul 28, 1998

Filed:

Jun 5, 1995

Appl. No.:

8/462158

Inventors:

Philip C. Gevas - Honolulu HI
Stephen L. Karr - Davis CA
Stephen Grimes - Davis CA
Richard L. Littenberg - Kai Lua HI

Assignee:

Aphton Corporation - Larkspur CA

International Classification:

A61K 3900
A61K 39385
A61K 3800
C07K 500

US Classification:

4241841

Abstract:

Immunogenic compositions useful for the treatment of ulcers or tumors whose growth is dependent on or stimulated by gastrin hormones are disclosed. The immunogenic compositions induce antibodies in a subject which selectively neutralize the specific hormones. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are disclosed. A method of reversing the inventive treatments by neutralizing the antibodies induced in vivo is also disclosed.

US Patent:

56227027, Apr 22, 1997

Filed:

Mar 30, 1994

Appl. No.:

8/219773

Inventors:

Philip C. Gevas - Honolulu HI
Stephen L. Karr - Davis CA
Stephen Grimes - Davis CA
Richard L. Littenberg - Kai Lua HI

Assignee:

Aphton Corporation - Woodland CA

International Classification:

C07K 500
A61K 3900
A61K 3938
A61K 3800

US Classification:

4241841

Abstract:

Immunogenic compositions useful for the treatment or prevention of gastric or duodenal ulcer disease are disclosed. The immunogenic compositions effectively operate by inducing antibodies in a subject which selectively neutralize specific peptide gastric hormones and inhibit the binding of the hormones to physiological receptors thus limiting the secretion of stomach acid. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are also disclosed.

US Patent:

50230778, Jun 11, 1991

Filed:

Jan 24, 1989

Appl. No.:

7/301353

Inventors:

Philip C. Gevas - Honolulu HI
Stephen L. Karr - Davis CA
Stephen Grimes - Davis CA
Richard L. Littenberg - Kai Lua HI

Assignee:

Aphton Corporation - Woodland CA

International Classification:

C07K 706
C07K 730
A61K 3900
A61K 3724

US Classification:

424 88

Abstract:

Immunogenic compositions useful for the treatment or prevention of gastric or duodenal ulcer disease are disclosed. The immunogenic compositions effectively operate by inducing antibodies in a subject which selectively neutralize specific peptide gastric hormones and inhibit the binding of the hormones to physiological receptors thus limiting the secretion of stomach acid. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are also disclosed.