Stephen Dale Lambert

US Patent:

6638760, Oct 28, 2003

Filed:

Dec 3, 1998

Appl. No.:

09/204865

Inventors:

Claudia Chiesa - Redwood City CA
George A. Fry - San Carlos CA
Vergine C. Furniss - San Mateo CA
Stephen M. Lambert - Castro Valley CA
Roger ONeill - San Carlos CA
Majid Mehrpouyan - San Jose CA

Assignee:

PE Corporation (NY) - Norwalk CO

International Classification:

C12M 134

US Classification:

4352872, 436 6, 436 911, 4362871, 536 231, 536 243, 536 2433

Abstract:

The present invention provides substrates and apparatuses for efficient, rapid and specific capture, and optimal recovery, of nucleic acids, as well as methods of their use. The substrate is porous in nature and has a capture polynucleotide capable of hybridizing to a target nucleic acid immobilized thereon. Upon flowing a sample containing or suspected of containing the target nucleic acid through the porous substrate, the target nucleic acid is rapidly captured. Following capture, the target nucleic acid can be efficiently recovered for subsequent use.

US Patent:

8375888, Feb 19, 2013

Filed:

May 7, 2007

Appl. No.:

12/599061

Inventors:

Stephen Mark Lambert - Castro Valley CA, US
Dennis Mullins - Sunnyvale CA, US
Cuong Manh Ta - San Jose CA, US
Peter Wing Leung - Fremont CA, US

Assignee:

Intermolecular, Inc. - San Jose CA

International Classification:

B05C 11/04

US Classification:

118413, 118414, 15 971, 901 43

Abstract:

A doctor blade assembly for use in combination with apparatus for forming a film on a substrate. The doctor blade assembly includes a doctor blade to be mounted on a programmable robot. The doctor blade has a bottom face and spacers at opposite ends of the body of the doctor blade extending a predetermined distance down below the bottom face of the body for contacting a substrate and spacing the bottom face from the substrate. The spacers are adjustable relative to the doctor blade for adjusting the predetermined distance according to the thickness of film to be formed on the substrate. Other aspects and methods are also disclosed.

US Patent:

8511664, Aug 20, 2013

Filed:

May 7, 2007

Appl. No.:

12/599065

Inventors:

Stephen Mark Lambert - Castro Valley CA, US
Cuong Manh Ta - San Jose CA, US
Dennis Mullins - Sunnyvale CA, US

Assignee:

Intermolecular, Inc. - San Jose CA

International Classification:

B23P 19/00

US Classification:

269903, 269 60

Abstract:

A substrate holder and method for using it to move a substrate. The holder comprises a frame having an inner periphery defining a first opening for receiving the substrate, and a shoulder projecting laterally inward from the inner periphery of the frame for supporting the substrate in the first frame opening. The shoulder has an inner periphery defining a second opening smaller than the first opening for receiving a substrate support. The holder and a substrate therein is moved to a position above the substrate support and then lowered to a position in which the shoulder of the holder is positioned below a top surface of the substrate support and the substrate is deposited on the top surface of the substrate support.

US Patent:

20090046535, Feb 19, 2009

Filed:

Jul 25, 2008

Appl. No.:

12/180001

Inventors:

Eric D. Carlson - Cupertino CA, US
Dave Huffman - Livermore CA, US
Grant Gavranovic - Palo Alto CA, US
Stephen Mark Lambert - Castro Valley CA, US
Luping Wu - Sunnyvale CA, US

International Classification:

B01F 11/04

US Classification:

366118, 901 2

Abstract:

A system for mixing powdered materials includes a cannula and an actuator adapted to vibrate the cannula. An optional fluid delivery system is operable to add fluid to the powdered mixture through the cannula. The cannula can be extended into a powder bed and vibrated by the actuator to mix the powder bed. Fluid can be added to the powder bed through the cannula. The systems and methods are suitable for preparing relatively small quantities of candidate mixtures for high-throughput screening. Sample mixtures prepared by the mixing system can be pressed into tablets that are substantially devoid of foreign objects used to mix the samples. The sample mixtures can be subjected to one or more tests, such as an accelerated aging or forced degradation test, to assess one or more characteristics of the sample mixtures.

US Patent:

20130104630, May 2, 2013

Filed:

Oct 26, 2012

Appl. No.:

13/661640

Inventors:

Thomas McWaid - Santa Cruz CA, US
Anny Tangkilisan - Redwood Shores CA, US
John Kirkwood - Los Gatos CA, US
Barry Wong - San Jose CA, US
Stephen Lambert - Castro Valley CA, US

Assignee:

FREESLATE, INC. - Sunnyvale CA

International Classification:

G01N 11/08

US Classification:

73 5409

Abstract:

A measurement apparatus and method for determining a viscosity of a fluid are disclosed. A predetermined pre-fill portion of a sample of the fluid is injected into a capillary at a predetermined flow rate. The pressure differential across the capillary is determined, and the measurement is aborted when the measured pressure is greater than a predetermined maximum pressure. When the measured pressure is less than the predetermined maximum pressure, the remaining portion of the sample is injected into through the capillary. The viscosity of the sample is calculated based on a pressure within the capillary during the injection of the remaining portion of the sample.

US Patent:

20220332756, Oct 20, 2022

Filed:

Jun 29, 2022

Appl. No.:

17/853738

Inventors:

- Pleasanton CA, US
Stephen LAMBERT - Castro Valley CA, US
Robert S. BUSACCA - San Francisco CA, US
Russell BURGE - Mountain View CA, US

International Classification:

C07K 1/34
B01D 61/14
B01D 61/18
B01D 65/08
G01N 1/34
C07K 16/06
G01N 1/40
G01N 35/10
C07K 16/00

Abstract:

Systems and methods for exchanging buffer solutions are disclosed. In accordance with some embodiments, the methods and systems for buffer exchange may be automated and/or the methods and systems may include mixing during filtering operations.

US Patent:

20200255472, Aug 13, 2020

Filed:

Apr 28, 2020

Appl. No.:

16/861099

Inventors:

- Pleasanton CA, US
Stephen LAMBERT - Castro Valley CA, US
Robert BUSACCA - San Francisco CA, US
Russell BURGE - Mountain View CA, US

International Classification:

C07K 1/34
B01D 61/14
G01N 35/10
G01N 1/40
G01N 1/34
C07K 16/06
C07K 16/00
B01D 65/08
B01D 61/18

Abstract:

Systems and methods for exchanging buffer solutions are disclosed. In accordance with some embodiments, the methods and systems for buffer exchange may be automated and/or the methods and systems may include mixing during filtering operations.

US Patent:

20170336311, Nov 23, 2017

Filed:

Aug 7, 2017

Appl. No.:

15/670980

Inventors:

- Pleasanton CA, US
Thomas McWaid - Santa Cruz CA, US
Anny Tangkilisan - Redwood Shores CA, US
John Kirkwood - Los Gatos CA, US
Barry Wong - San Jose CA, US
Stephen Lambert - Castro Valley CA, US

International Classification:

G01N 11/08

Abstract:

A measurement apparatus and method for determining a viscosity of a fluid are disclosed. A predetermined pre-fill portion of a sample of the fluid is injected into a capillary at a predetermined flow rate. The pressure differential across the capillary is determined, and the measurement is aborted when the measured pressure is greater than a predetermined maximum pressure. When the measured pressure is less than the predetermined maximum pressure, the remaining portion of the sample is injected into through the capillary. The viscosity of the sample is calculated based on a pressure within the capillary during the injection of the remaining portion of the sample.