Stephen D Lane

US Patent:

6480730, Nov 12, 2002

Filed:

Dec 20, 2000

Appl. No.:

09/742775

Inventors:

Christopher B. Darrow - Pleasanton CA
Stephen M. Lane - Oakland CA
Abraham P. Lee - Walnut Creek CA
Amy W. Wang - Berkeley CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61B 505

US Classification:

600347, 600345

Abstract:

An implantable chemical sensor system for medical applications is described which permits selective recognition of an analyte using an expandable biocompatible sensor, such as a polymer, that undergoes a dimensional change in the presence of the analyte. The expandable polymer is incorporated into an electronic circuit component that changes its properties (e. g. , frequency) when the polymer changes dimension. As the circuit changes its characteristics, an external interrogator transmits a signal transdermally to the transducer, and the concentration of the analyte is determined from the measured changes in the circuit. This invention may be used for minimally invasive monitoring of blood glucose levels in diabetic patients.

US Patent:

6673625, Jan 6, 2004

Filed:

Mar 30, 2001

Appl. No.:

09/823522

Inventors:

Stephen M. Lane - Oakland CA
Christopher B. Darrow - Pleasanton CA
Douglas R. Cary - San Francisco CA
Joe Anh Tran - San Diego CA

Assignee:

The Regents of the University of California - Oakland CA
MiniMed Inc. - Sylmar CA

International Classification:

G01N 3300

US Classification:

436 94, 436 95, 252700, 422 8207, 546 1, 546 13, 546 15, 546 16, 546 17, 546 26, 546 79, 546101, 546285, 546290, 546296, 546298, 546299

Abstract:

The present invention provides formulae for fluorescent compounds that have a number of properties which make them uniquely suited for use in sensors of analytes such as saccharides. The advantageous fluorescent properties include favorable excitation wavelengths, emission wavelengths, fluorescence lifetimes, and photostability. Additional advantageous properties include enhanced aqueous solubility, as well as temperature and pH sensitivity. The compound comprises an aryl or a substituted phenyl botonic acid that acts as a substrate recognition component, a fluorescence switch component, and a fluorophore. Fluorescent compounds are described that are excited at wavelengths greater than 400 nm and emit at wavelengths greater than 450 nm, which is advantageous for optical transmission through skin. The fluorophore is typically selected from transition metal-ligand complexes and thiazine, oxazine, oxazone, or oxazine-one as well as anthracene compounds. The fluorescent compound can be immobilized in a glucose permeable biocompatible polymer matrix that is implantable below the skin.

US Patent:

6682938, Jan 27, 2004

Filed:

Sep 15, 2000

Appl. No.:

09/663567

Inventors:

Stephen M. Lane - Oakland CA
Christopher B. Darrow - Pleasanton CA
Douglas R. Cary - Oakland CA
Joe Anh Tran - Livermore CA

Assignee:

The Regents of the University of California - Oakland CA
Minimed Inc. - Sylmar CA

International Classification:

G01N 3300

US Classification:

436172, 568 1

Abstract:

An analyte sensing fluorescent molecule that employs intramolecular electron transfer is designed to exhibit selected fluorescent properties in the presence of analytes such as saccharides. The selected fluorescent properties include excitation wavelength, emission wavelength, fluorescence lifetime, quantum yield, photostability, solubility, and temperature or pH sensitivity. The compound comprises an aryl or a substituted phenyl boronic acid that acts as a substrate recognition component, a fluorescence switch component, and a fluorophore. The fluorophore and switch component are selected such that the value of the free energy for electron transfer is less than about 3. 0 kcal mol. Fluorescent compounds are described that are excited at wavelengths greater than 400 nm and emit at wavelengths greater than 450 nm, which is advantageous for optical transmission through skin. The fluorophore is typically selected from transition metal-ligand complexes and thiazine, oxazine, oxazone, or oxazine-one as well as anthracene compounds. The fluorescent compound can be immobilized in a glucose permeable biocompatible polymer matrix that is implantable below the skin.

US Patent:

6818964, Nov 16, 2004

Filed:

Sep 30, 2002

Appl. No.:

10/261349

Inventors:

Michael P. Surh - Livermore CA
William D. Wilson - Pleasanton CA
Stephen M. Lane - Oakland CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

H01L 2900

US Classification:

257531, 257724

Abstract:

Nanochannel electrophoretic and electrochemical devices having selectively-etched nanolaminates located in the fluid transport channel. The normally flat surfaces of the nanolaminate having exposed conductive (metal) stripes are selectively-etched to form trenches and baffles. The modifications of the prior utilized flat exposed surfaces increase the amount of exposed metal to facilitate electrochemical redox reaction or control the exposure of the metal surfaces to analytes of large size. These etched areas variously increase the sensitivity of electrochemical detection devices to low concentrations of analyte, improve the plug flow characteristic of the channel, and allow additional discrimination of the colloidal particles during cyclic voltammetry.

US Patent:

7067351, Jun 27, 2006

Filed:

Jun 8, 2004

Appl. No.:

10/864778

Inventors:

Michael P. Surh - Livermore CA, US
William D. Wilson - Pleasanton CA, US
Stephen M. Lane - Oakland CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

H01L 21/44

US Classification:

438107, 438245, 438607, 257E21586, 257751, 257499, 427250, 427252, 42725515, 42725523, 42725526, 42725528, 4272557

Abstract:

Nanochannel electrophoretic and electrochemical devices having selectively-etched nanolaminates located in the fluid transport channel. The normally flat surfaces of the nanolaminate having exposed conductive (metal) stripes are selectively-etched to form trenches and baffles. The modifications of the prior utilized flat exposed surfaces increase the amount of exposed metal to facilitate electrochemical redox reaction or control the exposure of the metal surfaces to analytes of large size. These etched areas variously increase the sensitivity of electrochemical detection devices to low concentrations of analyte, improve the plug flow characteristic of the channel, and allow additional discrimination of the colloidal particles during cyclic voltammetry.

US Patent:

7118661, Oct 10, 2006

Filed:

Sep 30, 2002

Appl. No.:

10/261392

Inventors:

Michael P. Surh - Livermore CA, US
William D. Wilson - Pleasanton CA, US
Stephen M. Lane - Oakland CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

G01N 27/453

US Classification:

204601, 204643, 422100

Abstract:

A microfluidic device made from nanolaminate materials that are capable of electrophoretic selection of particles on the basis of their mobility. Nanolaminate materials are generally alternating layers of two materials (one conducting, one insulating) that are made by sputter coating a flat substrate with a large number of layers. Specific subsets of the conducting layers are coupled together to form a single, extended electrode, interleaved with other similar electrodes. Thereby, the subsets of conducting layers may be dynamically charged to create time-dependent potential fields that can trap or transport charge colloidal particles. The addition of time-dependence is applicable to all geometries of nanolaminate electrophoretic and electrochemical designs from sinusoidal to nearly step-like.

US Patent:

8428398, Apr 23, 2013

Filed:

Jun 29, 2010

Appl. No.:

12/826215

Inventors:

Deanna Lynn Thompson - Orangevale CA, US
Matthew A. Coleman - Oakland CA, US
Stephen M. Lane - Oakland CA, US
Dennis L. Matthews - Gold River CA, US
Joanna Albala - Stockton CA, US
Sebastian Wachsmann-Hogiu - Sacramento CA, US

Assignee:

Lawrence Livermore National Security, LLC - Livermore CA
The Regents of the University of California - Oakland CA

International Classification:

G06K 9/22

US Classification:

382313, 348294

Abstract:

A hand-held portable microarray reader for biodetection includes a microarray reader engineered to be small enough for portable applications. The invention includes a high-powered light-emitting diode that emits excitation light, an excitation filter positioned to receive the excitation light, a slide, a slide holder assembly for positioning the slide to receive the excitation light from the excitation filter, an emission filter positioned to receive the excitation light from the slide, a lens positioned to receive the excitation light from the emission filter, and a CCD camera positioned to receive the excitation light from the lens.

US Patent:

20020043651, Apr 18, 2002

Filed:

Apr 4, 2001

Appl. No.:

09/826745

Inventors:

Christopher Darrow - Pleasanton CA, US
Joe Satcher - Patterson CA, US
Stephen Lane - Oakland CA, US
Jennifer Gable - Livermore CA, US

International Classification:

G01N031/00

US Classification:

252/408100

Abstract:

The invention disclosed herein provides fluorescence based methods for the determination of polyhydroxylated analyte concentrations as well as optical polyhydroxylate analyte sensors and sensor systems. In particular, the invention provides methods of quantifying the abundances or concentrations of polyhydroxylate analyte by measuring changes in the fluorescence lifetimes. The methods of the invention are based on the observation that fluorescent sensor molecules capable of binding a polyhydroxylated analyte such as glucose have distinct fluorescent lifetimes depending upon whether they are in a form that is either bound to analyte or a form that is not bound to the analyte. The distinct and measurable differences in the fluorescence lifetimes of the different fluorescent sensor species can be used to determine the relative abundance of the bound and unbound fluorescent sensor species, a parameter which can then be correlated to the concentration of the analyte.