Stephen E Madden

US Patent:

7846667, Dec 7, 2010

Filed:

Aug 20, 2009

Appl. No.:

12/545028

Inventors:

Jin Jen - Baltimore MD, US
Gary A. Beaudry - Montclair NJ, US
Stephen L. Madden - Sudbury MA, US
Arthur H. Bertlesen - Ridgewood NJ, US
David Sidransky - Baltimore MD, US

Assignee:

Genzyme Corporation - Framingham MA
Johns Hopkins University - Baltimore MD

International Classification:

C12Q 1/68

US Classification:

435 6, 435 71, 536 235, 536 2431, 536 2433, 530350, 5303871, 5303877, 436 64

Abstract:

The present invention provides methods for aiding in the diagnoses of the neoplastic condition of a lung cell and methods of screening for a potential therapeutic agent for the reversal of the neoplastic condition.

US Patent:

8067240, Nov 29, 2011

Filed:

Nov 22, 2010

Appl. No.:

12/951449

Inventors:

Jin Jen - Baltimore MD, US
Gary A. Beaudry - Nutley NJ, US
Stephen L. Madden - Sudbury MA, US
Arthur H. Bertlesen - Ridgewood NJ, US
David Sidransky - Baltimore MD, US

Assignee:

Esoterix Genetic Laboratories, LLC - Burlington NC
Johns Hopkins University School of Medicine - Baltimore MD

International Classification:

G01N 33/50

US Classification:

436 64, 435 6, 435 71, 435 723, 530350, 536 235, 536 243

Abstract:

The present invention provides methods for aiding in the diagnoses of the neoplastic condition of a lung cell and methods of screening for a potential therapeutic agent for the reversal of the neoplastic condition.

US Patent:

8568985, Oct 29, 2013

Filed:

Jul 5, 2011

Appl. No.:

13/176222

Inventors:

Saraswati Sukumar - Columbia MD, US
Stephen L. Madden - Sudbury MA, US

Assignee:

Genzyme Corporation - Framingham MA
The Johns Hopkins University - Baltimore MD

International Classification:

C12Q 1/68
G01N 33/574

US Classification:

435 614, 435 723

Abstract:

To gain a better understanding of breast tumor angiogenesis, breast endothelial cells (ECs) were isolated and evaluated for gene expression patterns. When transcripts from breast ECs derived from normal and malignant breast tissues were compared, genes that were specifically elevated in tumor-associated breast endothelium were revealed. These results confirm that neoplastic and normal endothelium in human breast are distinct at the molecular level, and have significant implications for the development of anti-angiogenic therapies in the future.

US Patent:

20070178090, Aug 2, 2007

Filed:

Mar 31, 2004

Appl. No.:

10/551217

Inventors:

Saraswati Sukumar - Columbia MD, US
Stephen Madden - Sudbury MA, US

Assignee:

GENZYME CORPORATION - Framingham MA
THE JOHNS HOPKINS UNIVERSITY - Baltimore MD

International Classification:

A61K 39/395
C12Q 1/68
G01N 33/574

US Classification:

424144100, 435006000, 435007230, 424155100

Abstract:

To gain a better understanding of breast tumor angiogenesis, breast endothelial cells (ECs) were isolated and evaluated for gene expression patterns. When transcripts from breast ECs derived from normal and malignant breast tissues were compared, genes that were specifically elevated in tumor-associated breast endothelium were revealed. These results confirm that neoplastic and normal endothelium in human breast are distinct at the molecular level, and have significant implications for the development of anti-angiogenic therapies in the future.

US Patent:

20070218511, Sep 20, 2007

Filed:

Aug 14, 2006

Appl. No.:

11/504260

Inventors:

Jin Jen - Baltimore MD, US
Gary Beaudry - Montclair NJ, US
Stephen Madden - Sudbury MA, US
Arthur Bertlesen - Ridgewood NJ, US
David Sidransky - Baltimore MD, US

International Classification:

G01N 33/574
C12N 5/08
G01N 33/48

US Classification:

435007230, 435375000, 436063000

Abstract:

The present invention provides methods for aiding in the diagnoses of the neoplastic condition of a lung cell, and methods of screening for a potential therapeutic agent for the reversal of the neoplastic condition.

US Patent:

20090117038, May 7, 2009

Filed:

Nov 12, 2008

Appl. No.:

12/269418

Inventors:

Saraswati SUKUMAR - Columbia MD, US
Stephen L. Madden - Sudbury MA, US

Assignee:

Genzyme Corporation - Framingham MA
The Johns Hopkins University - Baltimore MD

International Classification:

A61K 51/00
C12Q 1/68
C12Q 1/02
C12Q 1/48
C12Q 1/42
C12Q 1/37
G01N 33/574
A61K 39/00
C12Q 1/34
G01N 33/53
G01N 33/573
C40B 30/04
A61K 39/395

US Classification:

424 149, 435 6, 435 29, 435 15, 435 21, 435 23, 435 18, 435 71, 435 74, 506 9, 4241741, 4241781, 4241581, 435 723, 4241841

Abstract:

To gain a better understanding of breast tumor angiogenesis, breast endothelial cells (ECs) were isolated and evaluated for gene expression patterns. When transcripts from breast ECs derived from normal and malignant breast tissues were compared, genes that were specifically elevated in tumor-associated breast endothelium were revealed. These results confirm that neoplastic and normal endothelium in human breast are distinct at the molecular level, and have significant implications for the development of anti-angiogenic therapies in the future.