Jingfang Q. Cutrone - Wallingford CT, US Lyndon M. Foster - Oceanside CA, US Kimberly D. Krampitz - Southington CT, US Stephen W. Mamber - Pawtucket RI, US Grace A. McClure - Northford CT, US Todd C. Peterson - Coronado CA, US Lisa C. Rupar - Woodbury CT, US Katie A. Thompson - Milford IA, US
A novel tyrosyl diester antibiotic is obtained from fermentation of a recombinant strain of designated WD 15684 (ATCC-202143). The new antibiotic, designated tyrissamycin, exhibits antibacterial activity, particularly against gram-positive bacteria.
The present invention relates to xanthone compounds isolated from the plant Hochr. (Clusiaceae), a Madagascar plant, which are potent cytotoxic agents.
Jingfang Cutrone - Wallingford CT, US Lyndon Foster - Carlsbad CA, US Kimberly Krampitz - Southington CT, US Stephen Mamber - Wethersfield CT, US Grace McClure - Northford CT, US Todd Peterson - Coronado CA, US Lisa Rupar - Woodbury CT, US Katie Thompson - Milford IA, US
International Classification:
A61K035/00 C12N001/20
US Classification:
424/115000, 435/253300
Abstract:
A novel tyrosyl diester antibiotic is obtained from fermentation of a recombinant strain of designated WD 15684 (ATCC-202143). The new antibiotic, designated tyrissamycin, exhibits antibacterial activity, particularly against gram-positive bacteria.
Jingfang Cutrone - Wallingford CT Lyndon M. Foster - Carlsbad CA Kimberly Krampitz - Southington CT Stephen W. Mamber - Wethersfield CT Grace McClure - Northford CT Todd C. Peterson - Coronado CA Lisa C. Rupar - Woodbury CT Katie A. Thompson - Milford IA
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
A61K 3566
US Classification:
424115
Abstract:
A novel tyrosyl diester antibiotic is obtained from fermentation of a recombinant strain of Streptomyces lividans designated Streptomyces lividans WD 15684 (ATCC-202143). The new antibiotic, designated tyrissamycin, exhibits antibacterial activity, particularly against gram-positive bacteria.
Mitsuaki Tsunakawa - Kanagawa, JP Li-Ping Chang - New Britain CT Stephen W. Mamber - Wethersfield CT Isia Bursuker - Cheshire CT Robert Hugill - Middletown CT
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C12P 1716 C12N 120
US Classification:
435118
Abstract:
The present invention relates to the novel antitumor antibiotic designated BMS-199687 and to its preparation. The compound is obtained by culturing a new strain of Actinomadura ferruginea. BMS-199687 demonstrates antitumor activity in standard antitumor animal model systems.
Mitsuaki Tsunakawa - Kanagawa, JP Li-Ping Chang - New Britain CT Stephen W. Mamber - Wethersfield CT Isia Bursuker - Cheshire CT Robert Hugill - Middletown CT
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
A01N 4376 C12P 1716 C07D26722
US Classification:
514374
Abstract:
The present invention relates to the novel antitumor antibiotic designated BMS-199687 and to its preparation. The compound is obtained by culturing a new strain of Actinomadura ferruginea. BMS-199687 demonstrates antitumor activity in standard antitumor animal model systems.
Name / Title
Company / Classification
Phones & Addresses
Stephen Mamber Vice-President
Beech Tree Labs, Inc Research And Development · Commercial Physical Research
117 Chapman St, Providence, RI 02905 220 W Exchange St, Providence, RI 02903 4012732060
Isbn (Books And Publications)
Cinema Verite in America:Studies in Uncontrolled Documentary: Studies in Uncontrolled Documentary