Stephen J Marx

US Patent:

7358347, Apr 15, 2008

Filed:

Mar 4, 1998

Appl. No.:

09/380337

Inventors:

Settara Chandrasekharappa - Gaithersburg MD, US
Pachiappan Manickam - Huntsville AL, US
Francis S. Collins - Rockville MD, US
Michael R. Emmert-Buck - Silver Spring MD, US
Larisa V. Debelenko - New York NY, US
Irina A. Lubensky - Silver Spring MD, US
Lance A. Liotta - Bethesda MD, US
Sunita K. Agarwal - Gaithersburg MD, US
Allen M. Spiegel - Bethesda MD, US
A. Lee Burns - Rockville MD, US
Stephen J. Marx - Chevy Chase MD, US
Zhengping Zhuang - Bethesda MD, US

Assignee:

The United States of America as represented by the Department of Health and Human Services - Washington DC

International Classification:

C07H 21/00
C07H 21/02
C07H 21/04
C12Q 1/68
C12P 19/26
C12P 19/34

US Classification:

536 231, 536 235, 536 243, 536 2431, 536 2433, 536 253, 435 6, 435 84, 435 911, 435 912

Abstract:

The invention relates to the discovery of a novel tumor suppressor gene which is associated with multiple endocrine neoplasia type 1. The gene has been designated MEN1 and the gene product is menin. The absence of this protein and associated mutations in the corresponding gene have been identified in individuals suffering from multiple endocrine neoplasia type 1. The identification of this marker for multiple endocrine neoplasia type 1 has diagnostic uses as well as for gene therapy.