Stephen E Matson

US Patent:

50574272, Oct 15, 1991

Filed:

Apr 7, 1988

Appl. No.:

7/178950

Inventors:

Stephen A. Wald - Wayland MA
Stephen L. Matson - Harvard MA
Charles M. Zepp - Berlin MA
David R. Dodds - Millis MA

Assignee:

Sepracor, Inc. - Marlborough MA

International Classification:

C12P 762

US Classification:

435280

Abstract:

This invention relates to a novel method of effecting aqueous enzymatic and homogeneous resolutions of racemic esters which exhibit enhanced aqueous solubility. The preferred embodiment of this invention relates to the resolutions which are effected by placing the enzyme and racemic esters in an aqueous phase wherein one of the ester enantiomers is preferentially and stereospecifically de-esterified to effect the resolution of the initial racemic mixture. In another embodiment of this invention, the resolutions are effected by placing the enzyme and racemic esters in an aqueous phase, and contacting this aqueous phase with an organic phase. The preferential and stereospecific de-esterification of one of the ester enantiomers is effected, and the chiral acid product of the de-esterification reaction is extracted into the organic phase.

US Patent:

50134361, May 7, 1991

Filed:

Jul 19, 1989

Appl. No.:

7/382615

Inventors:

Eric K. L. Lee - Acton MA
Vinay J. Kalyani - Chelmsford MA
Stephen L. Matson - Harvard MA

International Classification:

B01D 6136
B01D 6302

US Classification:

2103218

Abstract:

Low-ethanol wines, beer, distilled spirits, and other alcoholic beverages are produced by treating ordinary alcoholic beverages with novel membrane extraction methods. Semipermeable membranes and gas-phase extraction fluids are employed to selectively extract ethanol into the gas-phase, while leaving substantially intact the complement of other organic constituents that contribute to the color, aroma, and taste of the beverage. Methods are provided for balancing the water activity of the gas-phase extraction fluid about equal to that in the beverage, so as to inhibit water transport across the membrane independent of the ethanol/water selectivity of the membrane.

US Patent:

49331981, Jun 12, 1990

Filed:

Jan 12, 1989

Appl. No.:

7/296255

Inventors:

Eric K. L. Lee - Acton MA
Vinay J. Kalyani - Chelmsford MA
Stephen L. Matson - Harvard MA

International Classification:

C12G 300

US Classification:

426319

Abstract:

Low-ethanol wines, beer, distilled spirits, and other alcoholic beverages are produced by treating ordinary alcoholic beverages with novel membrane extraction methods. Semipermeable membranes and gas-phase extraction fluids are employed to selectively extract ethanol into the gas-phase, while leaving substantially intact the complement of other organic constituents that contribute to the color, aroma, and taste of the beverage. Methods are provided for balancing the water activity of the gas-phase extraction fluid about equal to that in the beverage, so as to inhibit water transport across the membrane independent of the ethanol/water selectivity of the membrane.

US Patent:

53825918, Jan 17, 1995

Filed:

Sep 8, 1993

Appl. No.:

8/118160

Inventors:

Timothy J. Barberich - Concord MA
Stephen L. Matson - Harvard MA
William J. Wechter - Redlands CA

Assignee:

Sepracor Inc. - Marlborough MA

International Classification:

A61K 3140

US Classification:

514413

Abstract:

Methods are disclosed utilizing optically pure R-ketorolac for the treatment of pain, including but not limited to pain associated with toothaches, headaches, sprains, joint pain and surgical pain, for example dental pain (e. g. , after periodontal surgery) and ophthalmic pain (e. g. , after cataract surgery) while avoiding adverse effects which are associated with the administration of the racemic mixture of ketorolac. The optically pure R-ketorolac is also useful in treating pyrexia while avoiding the adverse effects associated with the administration of the racemic mixture of ketorolac.

US Patent:

51435268, Sep 1, 1992

Filed:

May 2, 1991

Appl. No.:

7/695040

Inventors:

Eric K. Lee - Acton MA
Vinay J. Kalyani - Tewksbury MA
Stephen L. Matson - Harvard MA

Assignee:

Sepracor, Inc. - Marlborough MA

International Classification:

B01D 6136

US Classification:

55158

Abstract:

The method and apparatus of the present invention has general applicability to the manipulation of the concentration, by partial depletion or enrichment, of one or more volatile components in a given liquid while leaving the other volatile components in the liquid in a substantially undisturbed or unadulterated state.

US Patent:

50134477, May 7, 1991

Filed:

Jan 10, 1990

Appl. No.:

7/463098

Inventors:

Eric K. Lee - Acton MA
Vinay J. Kalyani - Tewksbury MA
Stephen L. Matson - Harvard MA

Assignee:

Sepracor - Marlbrough MA

International Classification:

B01D 6136

US Classification:

210640

Abstract:

The method and apparatus of the present invention has general applicability to the manipulation of the concentration, by partial depletion or enrichment, of one or more volatile components in a given liquid while leaving the other volatile components in the liquid in a substantially undisturbed or unadulterated state.