Stephen E Matson

US Patent:

50574272, Oct 15, 1991

Filed:

Apr 7, 1988

Appl. No.:

7/178950

Inventors:

Stephen A. Wald - Wayland MA
Stephen L. Matson - Harvard MA
Charles M. Zepp - Berlin MA
David R. Dodds - Millis MA

Assignee:

Sepracor, Inc. - Marlborough MA

International Classification:

C12P 762

US Classification:

435280

Abstract:

This invention relates to a novel method of effecting aqueous enzymatic and homogeneous resolutions of racemic esters which exhibit enhanced aqueous solubility. The preferred embodiment of this invention relates to the resolutions which are effected by placing the enzyme and racemic esters in an aqueous phase wherein one of the ester enantiomers is preferentially and stereospecifically de-esterified to effect the resolution of the initial racemic mixture. In another embodiment of this invention, the resolutions are effected by placing the enzyme and racemic esters in an aqueous phase, and contacting this aqueous phase with an organic phase. The preferential and stereospecific de-esterification of one of the ester enantiomers is effected, and the chiral acid product of the de-esterification reaction is extracted into the organic phase.

US Patent:

47786884, Oct 18, 1988

Filed:

Oct 11, 1985

Appl. No.:

6/786787

Inventors:

Stephen L. Matson - Harvard MA

Assignee:

Sepracor, Inc. - Marlborough MA

International Classification:

C12G 310

US Classification:

426425

Abstract:

Low-ethanol wines and other alcoholic beverages are produced by treating ordinary alcoholic beverages with novel membrane extraction methods. Semipermeable membranes and extraction fluids comprised either of a non-toxic, water-immiscible organic solvent or an aqueous solution of a low-molecular-weight but membrane-impermeable solute are used under mild conditions to selectively extract ethanol from alcoholic beverages, while leaving substantially intact the complement of other organic constituents that contribute to the color, aroma, and taste of the beverage. The methods disclosed may be adapted to continuous processing of alcohol-containing beverages, in which an ethanol-rich product is continuously recovered from the organic or aqueous extraction fluid and the latter is continuously regenerated and subsequently recycled to the membrane extraction unit.

US Patent:

50134361, May 7, 1991

Filed:

Jul 19, 1989

Appl. No.:

7/382615

Inventors:

Eric K. L. Lee - Acton MA
Vinay J. Kalyani - Chelmsford MA
Stephen L. Matson - Harvard MA

International Classification:

B01D 6136
B01D 6302

US Classification:

2103218

Abstract:

Low-ethanol wines, beer, distilled spirits, and other alcoholic beverages are produced by treating ordinary alcoholic beverages with novel membrane extraction methods. Semipermeable membranes and gas-phase extraction fluids are employed to selectively extract ethanol into the gas-phase, while leaving substantially intact the complement of other organic constituents that contribute to the color, aroma, and taste of the beverage. Methods are provided for balancing the water activity of the gas-phase extraction fluid about equal to that in the beverage, so as to inhibit water transport across the membrane independent of the ethanol/water selectivity of the membrane.

US Patent:

63096080, Oct 30, 2001

Filed:

Apr 23, 1999

Appl. No.:

9/298743

Inventors:

Peng Zhou - Westborough MA
Stephen Matson - Harvard MA

International Classification:

B01L 1100

US Classification:

422131

Abstract:

Methods and apparatus for the semi-automated synthesis of libraries of organic compounds are disclosed. More specifically, the present invention comprises multi-vessel reaction blocks, accessory components, and complementary workstations designed to facilitate the semi-automated production of libraries of chemical compounds by combinatorial and parallel synthesis techniques. The invention is particularly well suited to the conduct of solid-phase or solution-phase parallel syntheses of single compounds and compound mixtures in a high-throughput manner.

US Patent:

47957042, Jan 3, 1989

Filed:

Oct 11, 1985

Appl. No.:

6/786764

Inventors:

Stephen L. Matson - Harvard MA

Assignee:

Sepracor, Inc. - Marlborough MA

International Classification:

C12P 100
C12N 1108
C12N 1104
C12M 140

US Classification:

435 41

Abstract:

A catalyst such as an enzyme is contained in an asymmetric membrane between two immiscible liquid streams. A catalytic reaction is carried out by introducing a reactant to one stream and removing a product from the other stream. When the catalyst becomes deactivated, the membrane can be recharged with catalyst by displacing the deactivated catalyst and introducing fresh catalyst. The membrane has a skin layer that has pores sufficiently small so as to prevent leakage of the catalyst and a highly porous region that contains the catalyst. Insolubility of the catalyst in the immiscible liquid prevents loss of the catalyst for the highly porous region.

US Patent:

48244430, Apr 25, 1989

Filed:

Apr 7, 1988

Appl. No.:

7/178452

Inventors:

Stephen L. Matson - Harvard MA
Eric K. L. Lee - Acton MA
Dwayne T. Friesen - Bend OR
Donald J. Kelly - Bend OR

Assignee:

Bend Research, Inc. - Bend OR

International Classification:

B01D 5322

US Classification:

55 16

Abstract:

There is disclosed a composite immobulized liquid membrane of a solvent-swollen polymer and a microporous organic or inorganic support, the solvent being at least one highly polar solvent containing at least one nitrogen, oxygen, phosphorous or sulfur atom, and having a boiling point of at least 100. degree. C. and a specified solubility parameter. The solvent or solvent mixture is homogeneously distributed through the solvent-swollen polymer from 20% to 95% by weight. The membrane is suitable for acid gas scrubbing and oxygen/nitrogen separation.

US Patent:

49331981, Jun 12, 1990

Filed:

Jan 12, 1989

Appl. No.:

7/296255

Inventors:

Eric K. L. Lee - Acton MA
Vinay J. Kalyani - Chelmsford MA
Stephen L. Matson - Harvard MA

International Classification:

C12G 300

US Classification:

426319

Abstract:

Low-ethanol wines, beer, distilled spirits, and other alcoholic beverages are produced by treating ordinary alcoholic beverages with novel membrane extraction methods. Semipermeable membranes and gas-phase extraction fluids are employed to selectively extract ethanol into the gas-phase, while leaving substantially intact the complement of other organic constituents that contribute to the color, aroma, and taste of the beverage. Methods are provided for balancing the water activity of the gas-phase extraction fluid about equal to that in the beverage, so as to inhibit water transport across the membrane independent of the ethanol/water selectivity of the membrane.

US Patent:

53825918, Jan 17, 1995

Filed:

Sep 8, 1993

Appl. No.:

8/118160

Inventors:

Timothy J. Barberich - Concord MA
Stephen L. Matson - Harvard MA
William J. Wechter - Redlands CA

Assignee:

Sepracor Inc. - Marlborough MA

International Classification:

A61K 3140

US Classification:

514413

Abstract:

Methods are disclosed utilizing optically pure R-ketorolac for the treatment of pain, including but not limited to pain associated with toothaches, headaches, sprains, joint pain and surgical pain, for example dental pain (e. g. , after periodontal surgery) and ophthalmic pain (e. g. , after cataract surgery) while avoiding adverse effects which are associated with the administration of the racemic mixture of ketorolac. The optically pure R-ketorolac is also useful in treating pyrexia while avoiding the adverse effects associated with the administration of the racemic mixture of ketorolac.