Stephen Robert Monroe

US Patent:

20080220091, Sep 11, 2008

Filed:

Jan 7, 2008

Appl. No.:

11/970158

Inventors:

Stephen H. Monroe - Portland OR, US
Matthias Johannes Hoekstra - Amsterdam, NL
Albertus Justus Johannes Van Den Berg - Utrecht, NL

International Classification:

A61K 33/00
A61K 33/30
A61P 17/02
A61K 33/06

US Classification:

424642, 424682, 424722

Abstract:

Reactive oxygen species associated with a wound are modulated through treatment of the wound with a solution of metal ions selected from the group consisting of potassium ions, zinc ions, calcium ions and rubidium ions, at a pH of between about 5 and about 7. Preferably, citric acid is employed to adjust the pH of the solution. Application of the extract to a wound exhibiting superoxide anions has been found to be effective in the treatment of these wounds through the reduction of the level of superoxide anions. Moreover, treatment of partial thickness excision wounds as well as contact burn wounds with the present composition has been found to improve epithelialization of these wounds. In addition to the antioxidant activity of the present invention, treatment of the wound employing the present composition produces inhibitory effects on ROS production by human PMNs and on human complement activation, and therefore, is further beneficial in chronic wound management.

US Patent:

20100260863, Oct 14, 2010

Filed:

Dec 11, 2008

Appl. No.:

12/747890

Inventors:

Stephen H. Monroe - Portland OR, US

International Classification:

A61K 33/42
A61K 31/194
A61K 31/375
A61K 31/728
A61K 31/19
A61Q 19/00
A61Q 19/08

US Classification:

424605, 514574, 514474, 514 54, 514557

Abstract:

This invention relates to a composition for the topical or internal treatment of animal tissues to buffer and normalize the pH of the cellular environment while also effecting specific cellular membrane ion channels as a method to affect inflammation, proteases, reactive oxygen species and free radicals.

US Patent:

20110218618, Sep 8, 2011

Filed:

Mar 3, 2011

Appl. No.:

13/039487

Inventors:

Stephen H. Monroe - Portland OR, US

International Classification:

A61F 2/82
C08J 5/18
B32B 37/16

US Classification:

623 139, 623 142, 26433111, 156242

Abstract:

A method for bulk manufacture of a microporous sheet material from polyolefin fibers, where an average pore size in the material is controlled by calendering the material through low-energy rollers at a suitable temperature, pressure and speed. The material is useful to selectively pass or reject certain substances, and may be combined in a resilient, tube-shaped configuration to form a self-regenerating drug-delivering vascular stent that reduces inflammation at the stent site to prevent restenosis.

US Patent:

20140135284, May 15, 2014

Filed:

Nov 6, 2013

Appl. No.:

14/073153

Inventors:

Stephen H. MONROE - Portland OR, US

International Classification:

A61K 31/728
A61K 31/194
A61K 31/19
A61K 31/375

US Classification:

514 54, 514474, 514574, 514557

Abstract:

This invention relates to a buffering composition for the topical or internal treatment of animal tissues to buffer and normalize the pH of the cellular environment while also affecting specific cellular membrane ion channels as a method to affect inflammation, proteases, reactive oxygen species and free radicals, the composition containing a pharmaceutically-effective concentration of an acid and its base salt, where the counterions of the base salt are potassium and at least one of cesium and rubidium, or all three.