Stephen Paul O'Connor

US Patent:

6880576, Apr 19, 2005

Filed:

May 3, 2004

Appl. No.:

10/838877

Inventors:

Christoph D. Karp - Pasadena CA, US
Stephen D. O'Connor - Pasadena CA, US
Eugene Dantsker - Sierra Madre CA, US

Assignee:

Nanostream, Inc. - Pasadena CA

International Classification:

F15C001/14

US Classification:

137806, 137807, 137833, 204601, 73 6155

Abstract:

Microfluidic devices with multiple fluid process regions for subjecting similar samples to different process conditions in parallel are provided. One or more common fluid inputs may be provided to minimize the number of external fluid supply components. Solid materials such as chromatographic separation media or catalyst media is preferably provided in each fluid process region. Solid materials may be supplied to the devices in the form of slurry, with particles retained by porous elements or frits. Different fluid process regions may having different effective lengths, different solid material types or amounts, or may receive different ratios of common fluids supplied to the device. The flow resistances of dissimilar fluid process regions may be balanced passively with the addition of impedance elements in series with each fluid process region.

US Patent:

6919046, Jul 19, 2005

Filed:

Jun 7, 2002

Appl. No.:

10/164887

Inventors:

Stephen D. O'Connor - Pasadena CA, US
Christoph D. Karp - Pasadena CA, US
Marci Pezzuto - Altadena CA, US
Courtney Coyne - Pasadena CA, US
Steven E. Hobbs - West Hills CA, US
Eugene Dantsker - Sierra Madre CA, US

Assignee:

Nanostream, Inc. - Pasadena CA

International Classification:

G01N031/00

US Classification:

422100, 422 8205, 422 681, 422 99, 436174, 436179, 436180, 137 1518

Abstract:

Modular microfluidic systems includes a plurality of microfluidic modules, each capable of performing fluidic operations including, but not limited to, filtering, splitting, regulating pressure, mixing, metering, reacting, diverting, heating, cooling, and condensing are provided. The microfluidic modules are polymeric, stencil-based structures adapted to be coupled in sequence for performing biological or chemical synthesis, including, but not limited to, chemical and biological syntheses of organic, polymer, inorganic, oligonucleotide, peptide, protein, bacteria, and enzymatic products.

US Patent:

6935772, Aug 30, 2005

Filed:

May 21, 2003

Appl. No.:

10/444041

Inventors:

Christoph D. Karp - Pasadena CA, US
Stephen D. O'Connor - Pasadena CA, US
Paren P. Patel - Sierra Madre CA, US

Assignee:

Nanostream, Inc. - Pasadena CA

International Classification:

B01F013/00
G05B007/00

US Classification:

366341, 137833, 137827, 137550, 422101, 422103

Abstract:

Microfluidic devices capable of efficiently mixing two or more fluid are provided. Two or more microfluidic inlet channels defined in different sheets of material meet at an overlap region in fluid communication with an outlet channel. The channels are defined through the entire thickness of stencil sheets. The overlap region may include an aperture-defining spacer layer, and/or an impedance element, such as a porous membrane, adapted to distribute at least one fluid across the entire width of the outlet channel to promote reliable fluid mixing.

US Patent:

6977151, Dec 20, 2005

Filed:

Feb 20, 2002

Appl. No.:

10/081936

Inventors:

Jon Faiz Kayyem - Pasadena CA, US
Stephen D. O'Connor - Pasadena CA, US
Michael Gozin - Pasadena CA, US
Changjun Yu - Pasadena CA, US
Thomas J. Meade - Altadena CA, US

Assignee:

Clinical Micro Sensors, Inc. - Pasadena CA

International Classification:

C12Q001/68
C12M001/34
C07H021/02
C07H021/04

US Classification:

435 6, 4352872, 536 231, 536 243

Abstract:

The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.

US Patent:

6981522, Jan 3, 2006

Filed:

May 30, 2002

Appl. No.:

10/160393

Inventors:

Stephen D. O'Connor - Pasadena CA, US
Christoph D. Karp - Pasadena CA, US
Eugene Dantsker - Sierra Madre CA, US

Assignee:

Nanostream, Inc. - Pasadena CA

International Classification:

F15C 1/06
F16K 37/00

US Classification:

137803, 137833, 137828, 137559, 204601

Abstract:

Microfluidic devices having a plurality of functional features for performing one or more fluidic operations in parallel are provided. Reagents, samples or other fluids common to multiple functional features (“common fluids”) may be input into a microfluidic device or system through one or more distributing inputs that divide and distribute the common fluids as desired. The use of a multi-layer fabrication technique allows multiple distributing inputs to distribute to multiple functional features in a microfluidic device without undesirable fluid channel intersections.

US Patent:

6987263, Jan 17, 2006

Filed:

Dec 13, 2003

Appl. No.:

10/736154

Inventors:

Steven E. Hobbs - West Hills CA, US
Stephen D. O'Connor - Pasadena CA, US
Ronald C. Gamble - Altadena CA, US

Assignee:

Nanostream, Inc. - Pasadena CA

International Classification:

B01D 54/44
H01J 49/00

US Classification:

250288, 250287

Abstract:

Systems for analyzing multiple samples in parallel using mass spectrometric preferably coupled with fluid phase separation techniques are provided. A multi-analyzer mass spectrometer includes multiple inlets, multiple mass analyzers, and multiple transducers to conduct mass analyses of multiple samples in parallel. A modular mass analyzer may include a vacuum enclosure, a chassis, and multiple mass analysis modules disposed within the chassis. Modules are preferably disposed in a spatially compact two-dimensional array. A common multi-stage vacuum system may be utilized in conjunction with baffles or partitions disposed within and between modules to maintain differential vacuum conditions within the spectrometer utilizing a minimum number of pumps. Common control inputs may be provided to multiple modules or other components within a multi-analyzer spectrometer. Fluid phase separation devices for use with a multi-analyzer spectrometer may be microfluidic devices utilizing chromatographic, electrophoretic, or other separation methods.

US Patent:

7014992, Mar 21, 2006

Filed:

Jun 12, 1997

Appl. No.:

08/873978

Inventors:

Jon Faiz Kayyem - Pasadena CA, US
Stephen D. O'Connor - Pasadena CA, US
Michael Gozin - Pasadena CA, US
Changjun Yu - Pasadena CA, US
Thomas J. Meade - Altadena CA, US

Assignee:

Clinical Micro Sensors, Inc. - Pasadena CA

International Classification:

C12Q 1/68
C07H 21/02
C07H 21/04

US Classification:

435 6, 536 231, 536 243

Abstract:

The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.

US Patent:

7027683, Apr 11, 2006

Filed:

Aug 15, 2001

Appl. No.:

09/931585

Inventors:

Stephen D. O'Connor - Pasadena CA, US
Eugene Dantsker - Sierra Madre CA, US
Christoph D. Karp - Pasadena CA, US

Assignee:

Nanostream, Inc. - Pasadena CA

International Classification:

G02B 6/42
G02B 6/26

US Classification:

385 19, 385 16, 385 18

Abstract:

Fluidic systems, including microfluidic systems, are used to manipulate light by light-fluid interaction so as to affect reflection, refraction, absorption, optical filtering, or scattering of the beam. One or more fluids may be provided to a channel or chamber and exposed to an incident beam, and the proportion of at least one of a plurality of fluids may be varied. Light may interact with a discrete fluid plug subject to movement within a channel. One or more flexible members may be employed, such as to provide a variable lens. Fluidic optical devices may be used in applications including optical switching, optical filtering, or optical processing. Multiplexed fluidic optical systems are further provided.