Stephen J Rowe

US Patent:

6468520, Oct 22, 2002

Filed:

Dec 20, 1999

Appl. No.:

09/467359

Inventors:

Stephen C. Rowe - Wellesley MA
Jeffrey A. Hubbell - San Marino CA
Stephen J. Herman - Andover MA
Vae Sun - Palo Alto CA
Michael F. Lang - North Andover MA
George E. Selecman - Marblehead MA
Frederick F. Ahari - Newton MA

Assignee:

Focal, Inc. - Lexington MA

International Classification:

A61K 3174

US Classification:

424 7808, 424426, 604 20

Abstract:

An apparatus is provided for applying to a surface of mammalian tissue including soft, living tissue an initially fluent material and then activating the material by exposure to an energy source. The material may be a liquid capable of polymerization to a non-fluent state by exposure to actinic light. The device, and methods that may be practiced in association with the device, enable a wide range of medical conditions to be treated including, for example, the application of a barrier to soft tissue to prevent post-surgical adhesions.

US Patent:

6491657, Dec 10, 2002

Filed:

May 21, 2001

Appl. No.:

09/861924

Inventors:

Stephen Rowe - Wellesley MA
Joseph Kost - Omer, IS
Samir S. Mitragotri - Cambridge MA
Michael Pishko - Bryan TX
Matthew Davis - Boston MA

Assignee:

Sontra Medical, Inc. - Cambridge MA

International Classification:

A61B 1720

US Classification:

604 22

Abstract:

Methods and devices for application of ultrasound to a small area of skin for enhancing transdermal transport. An ultrasound beam having a first focal diameter is channelled into a beam having a second, smaller diameter without substantial loss of energy. Higher energy ultrasound can be used while causing less pain. Alternatively, ultrasound energy is applied through a vibrating element positioned just contacting, above or extending into the skin. Use of the element facilitates extraction of analyte and may enhance drug delivery. A two step noninvasive method involves application of ultrasound to increase skin permeability and removal of ultrasound followed by transdermal transport that can be further enhanced using a physical enhancer.

US Patent:

6699504, Mar 2, 2004

Filed:

Jan 29, 2001

Appl. No.:

09/772174

Inventors:

Stephen C. Rowe - Wellesley MA
Kalvin Yim - North Andover MA
Beadle P. Retnarajan - Beverly MA
Jeffrey A. Hubbell - Zumikon, CH
Durga Annavajula - Acton MA

Assignee:

Pelias Technologies, Inc. - Washington DC

International Classification:

A61K 914

US Classification:

424486, 424424, 424425, 424426, 424501, 424 50

Abstract:

The invention features articles for delivery of a biologically active substance, methods for making such articles, and methods for treating an animal using the articles.

US Patent:

6703037, Mar 9, 2004

Filed:

Oct 12, 2000

Appl. No.:

09/689575

Inventors:

Jeffrey A. Hubbell - Zumikon, CH
Mark T. Kieras - Newburyport MA
Eyal S. Ron - Lexington MA
Stephen C. Rowe - Wellesley MA

Assignee:

Pelias Technologies, Inc. - Washington DC

International Classification:

A61K 200

US Classification:

424426, 424422, 424433, 6048901, 6048911

Abstract:

A method for delivering a biologically active substance including the steps of: (a) combining said biologically active substance with a macromer; (b) forming a mixture of the combination formed in step (a); (c) polymerizing said mixture to form articles; and (d) administering said articles, or a portion thereof, to a mammal, where step (c) takes place in the absence of a polymerizable monovinyl monomer, is disclosed.

US Patent:

6939557, Sep 6, 2005

Filed:

Aug 26, 2003

Appl. No.:

10/650115

Inventors:

Stephen C. Rowe - Wellesley MA, US
Kalvin Yim - North Andover MA, US
Beadle P. Retnarajan - Beverly MA, US
Jeffrey A. Hubbell - Zumikon, CH
Durga Annavajula - Acton MA, US

Assignee:

Azopax Therapeutics LLC - Wellesley MA

International Classification:

A61F002/02
A61K009/14

US Classification:

424424, 424425, 424426

Abstract:

The invention features articles for delivery of a biologically active substance, methods for making such articles, and methods for treating an animal using the articles.

US Patent:

6960340, Nov 1, 2005

Filed:

Sep 17, 2003

Appl. No.:

10/664582

Inventors:

Stephen C. Rowe - Wellesley MA, US
Jeffrey A. Hubbell - San Marino CA, US
Stephen J. Herman - Andover MA, US
Vae Sun - Palo Alto CA, US
Michael F. Lang - Roswell GA, US
George E. Selecman - Salem MA, US
Frederick F. Ahari - Newton MA, US

Assignee:

Focal, Inc - Lexington MA

International Classification:

A61K031/74
A61F002/02

US Classification:

424 7808, 424426, 604 20

Abstract:

An apparatus is provided for applying to a surface of mammalian tissue including soft, living tissue an initially fluent material and then activating the material by exposure to an energy source. The material may be a liquid capable of polymerization to a non-fluent state by exposure to actinic light. The device, and methods that may be practiced in association with the device, enable a wide range of medical conditions to be treated including, for example, the application of a barrier to soft tissue to prevent post-surgical adhesions.

US Patent:

7037490, May 2, 2006

Filed:

Aug 8, 2002

Appl. No.:

10/215390

Inventors:

Stephen C. Rowe - Wellesley MA, US
Jeffrey A. Hubbell - San Marino CA, US
Stephen J. Herman - Andover MA, US
Vae Sun - Palo Alto CA, US
Michael F. Lang - North Andover MA, US
George E. Selecman - Salem MA, US
Frederick F. Ahari - Newton MA, US

Assignee:

Genzyme Corporation - Cambridge MA

International Classification:

A61K 31/74
A61F 2/02
A61N 1/30

US Classification:

424 7808, 424426, 604 20

Abstract:

An apparatus is provided for applying to a surface of mammalian tissue including soft, living tissue an initially fluent material and then activating the material by exposure to an energy source. The material may be a liquid capable of polymerization to a non-fluent state by exposure to actinic light. The device, and methods that may be practiced in association with the device, enable a wide range of medical conditions to be treated including, for example, the application of a barrier to soft tissue to prevent post-surgical adhesions.

US Patent:

20040197369, Oct 7, 2004

Filed:

Nov 17, 2003

Appl. No.:

10/715867

Inventors:

Jeffrey Hubbell - Zumikon, CH
Mark Kieras - Newburyport MA, US
Eyal Ron - Lexington MA, US
Stephen Rowe - Wellesley MA, US

International Classification:

A61F002/00
A61K009/14

US Classification:

424/423000, 424/486000

Abstract:

A method for delivering a biologically active substance including the steps of: (a) combining said biologically active substance with a macromer; (b) forming a mixture of the combination formed in step (a); (c) polymerizing said mixture to form articles; and (d) administering said articles, or a portion thereof, to a mammal, where step (c) takes place in the absence of a polymerizable monovinyl monomer, is disclosed.