Stephen F Schmidt

US Patent:

6395403, May 28, 2002

Filed:

Jul 6, 2001

Appl. No.:

09/899900

Inventors:

Stephen Raymond Schmidt - Silver Spring MD

International Classification:

B01J 2713

US Classification:

428570, 428550, 502301, 502325, 502337, 427305, 427306

Abstract:

A novel precious metal doped porous metal catalyst is disclosed. The precious metal is present in from 0. 01 to 1. 5 weight percent and distributed throughout the particles of porous metal to provide a surface to bulk ratio distribution of not greater than 60. The present invention is further directed to a process of forming said doped catalyst and to improved processes of catalytic hydrogenation of organic compounds.

US Patent:

6429337, Aug 6, 2002

Filed:

Jul 6, 2001

Appl. No.:

09/899902

Inventors:

Stephen Raymond Schmidt - Silver Spring MD

Assignee:

W. R. Grace Co.-Conn. - Columbia MD

International Classification:

C07C20900

US Classification:

564423

Abstract:

A novel precious metal doped porous metal catalyst is disclosed. The precious metal is present in from 0. 01 to 1. 5 weight percent and distributed throughout the particles of porous metal to provide a surface to bulk ratio distribution of not greater than 60. The present invention is further directed to a process of forming said doped catalyst and to improved processes of catalytic hydrogenation of organic compounds.

US Patent:

6558533, May 6, 2003

Filed:

Apr 13, 2001

Appl. No.:

09/833602

Inventors:

Stephen Raymond Schmidt - Silver Spring MD
Richard Franklin Wormsbecher - Dayton MD
Robert Hibbard Harding - Mainz, DE

Assignee:

W.R. Grace Co.-Conn - Columbia MD

International Classification:

C10G 2900

US Classification:

208244, 208208 R, 585274, 585276, 585900, 585904, 502 25, 502 28, 502 33, 502517

Abstract:

The present invention is directed to a method of desulfurization of a sulfur laden hydrocarbon liquids that comprises contacting the liquid with a sponge nickel metal alloy, removing the sulfur free liquid, regeneration of the alloy by contact with an aqueous solution of an oxidant and reusing the alloy for further desulfurization of additional sulfur laden liquid.

US Patent:

6696375, Feb 24, 2004

Filed:

Jun 7, 1995

Appl. No.:

08/485304

Inventors:

William Alan Welsh - Highland MD
Stephen Raymond Schmidt - Silver Spring MD

Assignee:

W. R. Grace Co.-Conn. - Columbia MD

International Classification:

C03C 3704

US Classification:

501 12

Abstract:

An improved flatting agent comprising an inorganic hydrogel having a pore volume of at least 1. 0 ml/g, an average particle size in the range 1 to 10 microns, and a particle size distribution such that when the flatting agent is dispersed in a coating, the fineness of grind is at least 4. 75 on the Hegman scale. The inorganic hydrogel flatting agents of this invention are prepared by milling an inorganic hydrogel under controlled temperature conditions wherein a volatiles content of at least 40 weight percent is maintained, to produce inorganic hydrogel particles characterized by a pore volume of at least 1. 0 ml/g, an average particle size in the range of 1 to 10 microns, and a particle size distribution such that when the flatting agent is dispersed in a coating, the fineness of grind is at least 4. 75 on the Hegman scale. Also provided in accordance with this invention are improved coating compositions comprising a full gloss coating containing the above described flatting agents dispersed in the full gloss coating in from 3 to 15 weight percent loading on a solids basis.

US Patent:

7375053, May 20, 2008

Filed:

Apr 7, 2003

Appl. No.:

10/408271

Inventors:

Stephen Raymond Schmidt - Silver Spring MD, US

Assignee:

W. R. Grace & Co.- Conn. - Columbia MD

International Classification:

B01J 23/74
B01J 23/00
B01J 21/00
B01J 20/00

US Classification:

502326, 502313, 502314, 502315, 502316, 502318, 502319, 502321, 502327, 502331, 502332, 502333, 502334, 502335, 502336, 502337, 502338, 502339, 502345, 502349, 502350, 502355, 502439, 50252724

Abstract:

Novel nickel and/or cobalt plated sponge based catalysts are disclosed. The catalyst have an activity and/or selectivity comparable to conventional nickel and/or cobalt sponge catalysts, e. g. , Raney nickel or Raney cobalt catalysts, but require a reduced content of nickel and/or cobalt. Catalysts in accordance with the invention comprise nickel and/or cobalt coated on at least a portion of the surface of a sponge support. Preferably, the sponge support comprises at least one metal other than or different from the metal(s) contained in the coating. The method of preparing the plated catalysts, and the method of using the catalysts in the preparation of organic compounds are also disclosed.

US Patent:

7569513, Aug 4, 2009

Filed:

Apr 21, 2008

Appl. No.:

12/148622

Inventors:

Stephen Raymond Schmidt - Silver Spring MD, US

Assignee:

W. R. Grace & Co.-Conn. - Columbia MD

International Classification:

B01J 23/00
B01J 21/00

US Classification:

502326, 502259, 502260, 502313, 502314, 502315, 502316, 502335, 502337, 502439, 50252724

Abstract:

Novel nickel and/or cobalt plated sponge based catalysts are disclosed. The catalyst have an activity and/or selectivity comparable to conventional nickel and/or cobalt sponge catalysts, e. g. , Raney nickel or Raney cobalt catalysts, but require a reduced content of nickel and/or cobalt. Catalysts in accordance with the invention comprise nickel and/or cobalt coated on at least a portion of the surface of a sponge support. Preferably, the sponge support comprises at least one metal other than or different from the metal(s) contained in the coating. The method of preparing the plated catalysts, and the method of using the catalysts in the preparation of organic compounds are also disclosed.

US Patent:

20040253647, Dec 16, 2004

Filed:

Aug 6, 2004

Appl. No.:

10/481954

Inventors:

Paul Mathews - Irvington-on-Hudson NY, US
Ralph Nixon - Tarrytown NY, US
Stephen Schmidt - Nutley NJ, US
Ying Jiang - Valhalla NY, US

International Classification:

G01N033/53
G01N033/567

US Classification:

435/007200

Abstract:

The present invention describes cell-based screening methods that allow for the elimination of false-positive results due to nonspecific toxicity of test compounds, while detecting those compounds that specifically modulate cellular metabolites in metabolic pathways associated with diseases and disorders, with particular regard to Alzheimer's disease. The methods are particularly suited to high-throughput screening techniques to identify compounds (drugs) that are effective in a cell-based system. The methods of the invention involve determining within a cell system the levels of both a metabolic precursor and a metabolite of interest and have broad application in high-throughput drug discovery and identification, particularly for precursor and metabolite molecules which are associated with disease and disease progression, such as Alzheimer's disease.

US Patent:

20050172344, Aug 4, 2005

Filed:

Nov 3, 2004

Appl. No.:

10/980922

Inventors:

Ottavio Arancio - New York NY, US
Paul Mathews - Irvington NY, US
Stephen Schmidt - Nutley NJ, US
Ralph Nixon - Tarrytown NY, US
Fortunato Battaglia - New York NY, US
Fabrizio Trinchese - Rome, IT
Shumin Liu - Tappan NY, US

International Classification:

A01K067/027
C12N005/06

US Classification:

800012000, 435354000

Abstract:

The present invention describes a dissociated cell culture system comprising cells of the hippocampus, one of the brain areas affected by Alzheimer's Disease (AD) or amyloid beta-related diseases. This culture system comprises hippocampal neuronal and glial cells from animal models of AD, particularly, but not limited to, double transgenic mice expressing both the human APP mutation (K670N:M671L) (mAPP), and the human PS1 mutation (M146L) (mPS1), and serves as a powerful tool for the screening and testing of compounds and substances, e.g., drugs, for their ability to affect, treat, or prevent AD or β-amyloid-related diseases. The effects of a test substance on the cells in this culture system can be quantitatively assessed to determine if the test substance affects the cells biochemically and/or electrophysiologically, and/or optically, and/or immunocytochemically. The present in vitro culture system is advantageous for AD drug screening, because it is rapid and efficient. By contrast, even in the fastest animal model of AD, pathology does not start before the end of the second month. If such in vivo animal models are used, it is necessary to wait at least the two month time duration or longer to test for drug efficacy for AD treatment or prevention. At the same time the present invention provides a tool for production of amyloid-beta that can be used for electrophysiological, behavioral, and toxicological studies.