Stephen T Smiley

US Patent:

6416971, Jul 9, 2002

Filed:

May 8, 1991

Appl. No.:

07/695141

Inventors:

Ellis L. Reinherz - Lincoln MA
Jiri Novotny - Princeton NJ
Stephen T. Smiley - Boston MA
Ping Li - Cambridge MA
Ramesh Ganju - Boston MA

Assignee:

E.R. Squibb Sons, Inc. - Princeton NJ
Dana Farber Cancer Institute - Boston MA

International Classification:

C12P 2103

US Classification:

435 691

Abstract:

Soluble, single chain T cell receptors, nucleic acid sequences, particularly DNA sequences, encoding the soluble, single chain T cell receptor, expression vectors containing the DNA sequences, and host cells containing the expression vectors.

US Patent:

20080159983, Jul 3, 2008

Filed:

Dec 27, 2007

Appl. No.:

12/005767

Inventors:

Stephen Smiley - Saranac Lake NY, US
Lawrence Johnson - Saranac Lake NY, US
Isis Mullarky - Pembroke VA, US

International Classification:

A61K 38/21
A61K 38/47
A61K 38/17
C12Q 1/00
C12Q 1/68
A61K 38/02
A61K 39/395

US Classification:

424 854, 424 9461, 4241581, 514 12, 514 2, 435 4, 435 6

Abstract:

The present invention relates to methods and compositions for the prevention and treatment of anemia. Anemia is characterized by a deficiency in red blood cells (RBCs) or hemoglobin, thereby reducing the supply of oxygen to tissues and organs. The invention is based on the discovery that interleukin-15 (IL-15) acts downstream of interferon-gamma (IFNγ) to suppress erythropoiesis. The methods and compositions of the invention may be used in the treatment of anemia accompanying a variety of illnesses characterized by a decrease in RBCs.

US Patent:

20110236376, Sep 29, 2011

Filed:

Jan 20, 2011

Appl. No.:

13/010317

Inventors:

STEPHEN T. SMILEY - SARANAC LAKE NY, US
LAURA HAYNES - SARANAC LAKE NY, US
TROY DOUGLAS RANDALL - ROCHESTER NY, US

International Classification:

A61K 39/42
A61P 31/16

US Classification:

4241331, 4241591, 4241471

Abstract:

The prevention and treatment of secondary bacterial pneumonia is described, by using passive immunization with antibodies (e.g. polyclonal, monoclonal, etc.) to one or more conserved influenza proteins. Both antibodies and fragments thereof are contemplated, raised against conserved proteins such as nucleoproteins.

US Patent:

20130273092, Oct 17, 2013

Filed:

Oct 20, 2011

Appl. No.:

13/879334

Inventors:

Stephen T. Smiley - Saranac Lake NY, US

Assignee:

Trudeau Institute - Sarananc Lake NY

International Classification:

A61K 39/02

US Classification:

4241901, 4242341, 435 724

Abstract:

This invention relates to vaccine formulations comprising the YopE peptide antigen or subparts thereof. The invention also relates to methods of vaccinating subjects at risk of infection as well as assays for measuring immune response to plague vaccines.

US Patent:

51697882, Dec 8, 1992

Filed:

Jun 9, 1989

Appl. No.:

7/363674

Inventors:

Lan B. Chen - Lexington MA
Glenn D. Steele - Swampscott MA
Stephen T. Smiley - Stratford CT

Assignee:

New England Deaconess Hospital Corporation - Boston MA

International Classification:

C01N 2176

US Classification:

436172

Abstract:

Disclosed is a method of detecting a localized biochemical event in a cell, wherein said event results in a change in the membrane potential of that cell. The method includes treating the cell with a composition containing a lipophilic, cationic dye having a delocalized positive charge and the ability to undergo multiple changes in fluorescence spectra upon aggregation. The cell is treated with the dye for a time sufficient to enable the dye to associate with the cell. Dye which has not associated with the cell is then removed. Fluorescence is observed when the cell is exposed to light having a wavelength suitable for exciting the dye. The spectrum obtained is indicative of the relative membrane potential of said cell, and a change in that membrane potential being indicative of the occurrence of a biochemical event.