Stephen G Stroud

US Patent:

6482950, Nov 19, 2002

Filed:

Jun 6, 1995

Appl. No.:

08/479077

Inventors:

Paulina P. Garcia - Arlington MA
John W. Lee - Still River MA
John L. Marshall - Somerville MA
Donald A. McGowan - Bedford MA
Anthony J. Puttick - Arlington MA
Thomas K. Spencer - Lexena KS
Stephen G. Stroud - Medford MA
Stephen J. Telfer - Arlington MA
Michael J. Zuraw - Arlington MA

Assignee:

Polaroid Corporation - Cambridge MA

International Classification:

C07D47100

US Classification:

546 66, 549 13, 549 23, 549407, 549427, 562899

Abstract:

Squarylium compounds of the formula: wherein Q and Q are each independently a pyrylium, thiopyrylium, selenopyrylium, benzpyrylium, benzthiopyrylium or benzselenopyrylium nucleus, and R and R are each independently an aliphatic or cycloaliphatic group, can be prepared by reacting a squaric acid derivative of the formula: with a compound of the formula Q CH R in the presence of a base. The derivatives of Formula II may be prepared by condensing a 2,3,4,4-tetrahalocyclobut-2-en-1-one with a compound of the formula Q CH R in the presence of a base to produce a compound of the formula: wherein Q and R are as defined above, and X represents chlorine or bromine, and hydrolyzing the compound of Formula III. Alternatively, the derivatives of Formula II may be prepared by reacting a diester, monoacid chloride monoester or diacid chloride of squaric acid with a compound of the formula Q CH R in the presence of a base, followed by hydrolysis of the resultant monoacid chloride or monoester derivative of the compound of Formula II to the parent compound.

US Patent:

7018457, Mar 28, 2006

Filed:

Nov 12, 2003

Appl. No.:

10/706417

Inventors:

Michael J. Berger - Chestnut Hill MA, US
Michael P. Filosa - Medfield MA, US
Stephen Stroud - Medford MA, US

Assignee:

Polaroid Corporation - Waltham MA

International Classification:

C09D 11/02
C09B 45/00
B41J 2/01

US Classification:

106 315, 534710, 534711, 347100

Abstract:

There are described metal-complexed azo dyes which are useful in ink jet printing applications. Also described are ink jet ink compositions including a dye of the invention as well as ink jet printing methods and apparatus.

US Patent:

7572784, Aug 11, 2009

Filed:

May 12, 2005

Appl. No.:

11/127855

Inventors:

Christopher F. Claiborne - Cambridge MA, US
Lloyd J. Payne - Cambridge, GB
Richard J. Boyce - Cambridge, GB
Todd B. Sells - Bellingham MA, US
Stephen G. Stroud - Medford MA, US
Stuart Travers - Bedfordshire, GB
Tricia J. Vos - Medford MA, US
Gabriel S. Weatherhead - Cambridge MA, US

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

A61P 35/00
A61K 31/55
C07D 487/00

US Classification:

514215, 540578

Abstract:

This invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treatment of cancer.

US Patent:

7718648, May 18, 2010

Filed:

Aug 6, 2007

Appl. No.:

11/890406

Inventors:

Christopher F. Claiborne - Cambridge MA, US
Todd B. Sells - Bellingham MA, US
Stephen G. Stroud - Medford MA, US

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

A61P 35/00
A61K 31/55
C07D 487/00

US Classification:

514215, 540577, 540578

Abstract:

This invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treatment of cancer.

US Patent:

8026246, Sep 27, 2011

Filed:

Nov 14, 2007

Appl. No.:

11/985277

Inventors:

Christopher F. Claiborne - Cambridge MA, US
Todd B. Sells - Bellingham MA, US
Stephen G. Stroud - Medford MA, US

Assignee:

Millennium Pharmaceuticials, Inc. - Cambridge MA

International Classification:

A61K 31/505
C07D 491/00

US Classification:

514267, 544250

Abstract:

The present invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides potent inhibitors of Aurora A kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treatment of cancer.

US Patent:

8399659, Mar 19, 2013

Filed:

May 27, 2009

Appl. No.:

12/472583

Inventors:

Christoper F. Claiborne - Cambridge MA, US
Lloyd J. Payne - Cambridge, GB
Richard J. Boyce - Boxwoth, GB
Todd B. Sells - Bellingham MA, US
Stephen G. Stroud - Medford MA, US
Stuart Travers - Shefford, GB
Tricia J. Vos - Medford MA, US
Gabriel S. Weatherhead - Salem MA, US

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

C07D 487/04

US Classification:

540587

Abstract:

This invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treatment of cancer.

US Patent:

20070185087, Aug 9, 2007

Filed:

Dec 21, 2006

Appl. No.:

11/643600

Inventors:

Christoper Claiborne - Cambridge MA, US
Lloyd Payne - Cambridge, GB
Richard Boyce - Boxworth, GB
Todd Sells - Bellingham MA, US
Stephen Stroud - Medford MA, US
Stuart Travers - Meppershall, GB
Tricia Vos - Medford MA, US
Gabriel Weatherhead - Salem MA, US

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

A61K 31/55
C07D 487/14

US Classification:

514215000, 540578000

Abstract:

This invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treatment of cancer.

US Patent:

20100197924, Aug 5, 2010

Filed:

Dec 16, 2009

Appl. No.:

12/639239

Inventors:

Alexandra E. Gould - Cambridge MA, US
Sean J. Harrison - Belmont MA, US
Hirotake Mizutani - Cambridge MA, US
Ming Shen - Winchester MA, US
Thomas E. Smyser - Franklin MA, US
Stephen G. Stroud - Medford MA, US

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

C07D 471/04
C07C 211/38
C07C 209/26
C07C 69/76
C07C 67/24
C07C 229/54
C07C 227/04
C07C 67/00
C07D 233/64
C07D 231/12

US Classification:

546123, 564307, 560 51, 562449, 560 38, 562444, 5483435, 5483771

Abstract:

The present invention relates to synthetic processes for preparation of aminotetralin compounds with kinase inhibitory activity. The invention also provides synthetic intermediates useful in the processes of the invention.