Stephen W Stroud

US Patent:

20140046055, Feb 13, 2014

Filed:

Oct 3, 2012

Appl. No.:

13/644216

Inventors:

MILLENNIUM PHARMACEUTICALS, INC. - , US
Lloyd J. Payne - Cambridge, GB
Richard J. Boyce - Boxworth, GB
Todd B. Sells - Bellingham MA, US
Stephen G. Stroud - Medford MA, US
Stuart Travers - Meppershall, GB
Tricia J. Vos - Medford MA, US
Gabriel S. Weatherhead - Cambridge MA, US

Assignee:

MILLENNIUM PHARMACEUTICALS, INC. - Cambridge MA

International Classification:

C07D 487/04

US Classification:

540578

Abstract:

This invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treatment of cancer.

US Patent:

59142138, Jun 22, 1999

Filed:

Oct 6, 1997

Appl. No.:

8/944284

Inventors:

Jurgen M. Grasshoff - Hudson MA
John L. Marshall - Somerville MA
Richard A. Minns - Arlington MA
Socorro M. Ramos - North Andover MA
Stephen G. Stroud - Medford MA
Stephen J. Telfer - Arlington MA
Haixin Yang - Durham NC
Roger A. Boggs - Wayland MA
Eric S. Kolb - Acton MA

Assignee:

Polaroid Corporation - Cambridge MA

International Classification:

G03C 1492
G03C 1494
G03C 176

US Classification:

4302701

Abstract:

A process for generation of acid uses a medium comprising a first acid-generating component capable of generating a first acid, and a secondary acid generator, this secondary acid generator being capable of thermal decomposition to form a secondary acid, the thermal decomposition of the secondary acid generator being catalyzed by the first acid. At least part of the medium is exposed to so as to cause formation of the first acid from the first acid-generating component; and the medium is then heated to cause, in the exposed part of the medium, acid-catalyzed thermal decomposition of the secondary acid generator and formation of the secondary acid. The secondary acid generator has a first site bearing a first leaving group and a second site bearing a second leaving group, the first leaving group being capable of protonation by the first acid, with expulsion of the first leaving group to form a cation which electrophilically adds to an unsaturated reagent bearing a proton at the site of addition and a proton-containing nucleophilic grouping at an adjacent site, following which said proton on the reagent is lost and the second leaving group is displaced by said nucleophilic grouping, the second leaving group, in combination with a proton, forming the secondary acid. Preferred variants of the process are of the types described in U. S. Pat. Nos. 5,286,612; 5,334,489; 5,395,736; 5,441,850 and 5,453,345.

US Patent:

61106380, Aug 29, 2000

Filed:

Nov 27, 1996

Appl. No.:

8/757195

Inventors:

Roger A. Boggs - Wayland MA
Jurgen M. Grasshoff - Hudson MA
Eric S. Kolb - Ipswich MA
John L. Marshall - Somerville MA
Richard A. Minns - Arlington MA
Socorro M. Ramos - North Andover MA
Stephen G. Stroud - Medford MA
Stephen J. Telfer - Arlington MA
Haixin Yang - Norwood MA

Assignee:

Polaroid Corporation - Cambridge MA

International Classification:

C03C 1492
C03C 1494
C03C 176

US Classification:

4302701

Abstract:

A process for generation of acid uses a medium comprising a first acid-generating component capable of generating a first acid, and a secondary acid generator, this secondary acid generator being capable of thermal decomposition to form a secondary acid, the thermal decomposition of the secondary acid generator being catalyzed by the first acid. At least part of the medium is exposed to so as to cause formation of the first acid from the first acid-generating component; and the medium is then heated to cause, in the exposed part of the medium, acid-catalyzed thermal decomposition of the secondary acid generator and formation of the secondary acid. The secondary acid generator has a first site bearing a first leaving group and a second site bearing a second leaving group, the first leaving group being capable of protonation by the first acid, with expulsion of the first leaving group, followed by loss of a proton from the secondary acid generator to form an unstable intermediate, which then fragments with loss of the second leaving group, accompanied by either (a) loss of a second proton; or (b) addition of a proton-containing nucleophile, followed by loss of a proton, the second leaving group, in combination with a proton, forming the secondary acid. Preferred variants of the process are of the types described in U. S. Pat. Nos. 5,286,612; 5,334,489; 5,395,736; 5,441,850 and 5,453,345.

US Patent:

59773510, Nov 2, 1999

Filed:

May 20, 1993

Appl. No.:

8/065350

Inventors:

Peter K. Chu - Acton MA
Serajul Haque - Braintree MA
Anthony J. Puttick - Arlington MA
Socorro M. Ramos - Belmont MA
Robert P. Short - Arlington MA
Stephen G. Stroud - Medford MA
Stephen J. Telfer - Arlington MA
Michael J. Zuraw - Arlington MA

Assignee:

Polaroid Corporation - Cambridge MA

International Classification:

C07D34500
C07D33504
C07D31104

US Classification:

540 1

Abstract:

Dyes comprising an inner salt of a compound of the formula: Q. sup. 1 =Z-Q. sup. 2 wherein: Q. sup. 1 is a 4-(benz[b]-4H-pyrylium)methylidene, 4-(benz[b]-4H-thiopyrylium)methylidene or 4-(benz[b]-4H-selenopyrylium)methylidene grouping; Z is a 1,3-(2-hydroxy-4-oxo-2-cyclobutylidene) hydroxide or 1,3-(2-hydroxy-4,5-dioxo-2-cyclopentylidene) hydroxide ring; and Q. sup. 2 is a 4-(benz[b]-4H-pyran-4-ylidene)methyl, 4-(benz[b]-4H-thiopyran-4-ylidene)methyl or 4-(benz[b]-4H-selenopyran-4-ylidene)methyl grouping; wherein at least one of the groupings Q. sup. 1 and Q. sup. 2 carries at its 2-position a substituent in which a non-aromatic carbon atom is bonded directly to the benzpyrylium, benzthiopyrylium or benzselenopyrylium nucleus, subject to the proviso that if this 2-substituent contains an aromatic nucleus, this aromatic nucleus is not conjugated with the benzpyrylium, benzthiopyrylium or benzselenopyrylium nucleus to which it is attached, are useful as visible and near infra-red absorbers, having high extinction coefficients and improved solubility in polymeric media.

US Patent:

44812787, Nov 6, 1984

Filed:

Oct 29, 1982

Appl. No.:

6/437617

Inventors:

Patrick F. King - Needham MA
Stephen G. Stroud - Brighton MA

Assignee:

Polaroid Corporation - Cambridge MA

International Classification:

G03C 140
G03C 554
G03C 700
C09B 4500

US Classification:

430225

Abstract:

Novel chrome complexed azo and azomethine yellow dye developers which include a substantially colorless symmetrical ligand. Also disclosed are photographic products and processes which utilize the dye developers.

US Patent:

56270143, May 6, 1997

Filed:

Jun 2, 1995

Appl. No.:

8/460229

Inventors:

Peter K. Chu - Acton MA
Serajul Haque - Braintree MA
Anthony J. Puttick - Arlington MA
Socorro M. Ramos - Belmont MA
Robert P. Short - Arlington MA
Stephen G. Stroud - Medford MA
Stephen J. Telfer - Arlington MA
Michael J. Zuraw - Arlington MA

Assignee:

Polaroid Corporation - Cambridge MA

International Classification:

G03C 1725
G03C 1735
G03C 173

US Classification:

430332

Abstract:

Dyes comprising an inner salt of a compound of the formula: Q. sup. 1 =Z-Q. sup. 2 wherein: Q. sup. 1 is a 4-(benz[b]-4H-pyrylium)methylidene, 4-(benz[b]-4H-thiopyrylium)methylidene or 4-(benz[b]-4H-selenopyrylium)methylidene grouping; Z is a 1,3-(2-hydroxy-4-oxo-2-cyclobutylidene) hydroxide or 1,3-(2-hydroxy-4,5-dioxo-2-cyclopentylidene) hydroxide ring; and Q. sup. 2 is a 4-(benz[b]-4H-pyran-4-ylidene)methyl, 4-(benz[b]-4H-thiopyran-4-ylidene)methyl or 4-(benz[b]-4H-selenopyran-4-ylidene)methyl grouping; wherein at least one of the groupings Q. sup. 1 and Q. sup. 2 carries at its 2-position a substituent in which a non-aromatic carbon atom is bonded directly to the benzpyrylium, benzthiopyrylium or benzselenopyrylium nucleus, subject to the proviso that if this 2-substituent contains an aromatic nucleus, this aromatic nucleus is not conjugated with the benzpyrylium, benzthiopyrylium or benzselenopyrylium nucleus to which it is attached, are useful as visible and near infra-red absorbers, having high extinction coefficients and improved solubility in polymeric media.

US Patent:

63070855, Oct 23, 2001

Filed:

Jul 28, 2000

Appl. No.:

9/627939

Inventors:

Jurgen M. Grasshoff - Hudson MA
John L. Marshall - Somerville MA
Richard A. Minns - Arlington MA
Socorro M. Ramos - North Andover MA
Stephen G. Stroud - Medford MA
Stephen J. Telfer - Arlington MA
Haixin Yang - Norwood MA
Roger A. Boggs - Wayland MA
Eric S. Kolb - Acton MA

Assignee:

Polaroid Corporation - Cambridge MA

International Classification:

C07F 902

US Classification:

558208

Abstract:

A process for generation of acid uses a medium comprising a first acid-generating component capable of generating a first acid, and a secondary acid generator, this secondary acid generator being capable of thermal decomposition to form a secondary acid, the thermal decomposition of the secondary acid generator being catalyzed by the first acid. At least part of the medium is exposed to so as to cause formation of the first acid from the first acid-generating component; and the medium is then heated to cause, in the exposed part of the medium, acid-catalyzed thermal decomposition of the secondary acid generator and formation of the secondary acid. The secondary acid generator has a first site bearing a first leaving group and a second site bearing a second leaving group, the first leaving group being capable of protonation by the first acid, with expulsion of the first leaving group to form a cation which electrophilically adds to an unsaturated reagent bearing a proton at the site of addition and a proton-containing nucleophilic grouping at an adjacent site, following which said proton on the reagent is lost and the second leaving group is displaced by said nucleophilic grouping, the second leaving group, in combination with a proton, forming the secondary acid. Preferred variants of the process are of the types described in U. S. Pat. Nos. 5,286,612; 5,334,489; 5,395,736; 5,441,850 and 5,453,345.

US Patent:

44812868, Nov 6, 1984

Filed:

Oct 29, 1982

Appl. No.:

6/437611

Inventors:

Patrick F. King - Needham MA
Stephen G. Stroud - Brighton MA

Assignee:

Polaroid Corporation - Cambridge MA

International Classification:

G03C 554
G03C 142

US Classification:

430441

Abstract:

Novel compounds which are capable of forming a coordination complex with a metal and which include a silver halide developing substituent or a precursor thereof. The compounds are useful as silver halide developing agents and as intermediates for dye developers which are utilized in photographic applications.