Stephen E. Webber - San Diego CA Peter S. Dragovich - Encinitas CA Thomas J. Prins - Cardiff CA Siegfried H. Reich - San Diego CA Ethel S. Littlefield - San Diego CA Joseph T. Marakovits - Encinitas CA Robert E. Babine - Carlsbad CA Ted M. Bleckman - La Jolla CA
Picornaviral 3C protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of picornaviral 3C proteases. These compounds, as well as pharmaceutical compositions that contain these compounds, are suitable for treating patients or hosts infected with one or more picornaviruses. Several novel methods and intermediates can be used to prepare the novel picornaviral 3C protease inhibitors of the present invention.
Tricyclic Inhibitors Of Poly(Adp-Ribose) Polymerases
Stephen Evan Webber - San Diego CA Jayashree Tikhe - San Diego CA Lars Henrik Thoresen - College Station TX
Assignee:
Agouron Pharmaceuticals, Inc. - La Jolla CA
International Classification:
A61K 3155
US Classification:
51421206, 540520
Abstract:
Compounds of the formula below are poly(ADP-ribosyl)transferase (PARP) inhibitors, and are useful as therapuetics in treatment of cancers and the amelioration of the effects of stroke, head trauma, and nuerodegenerative disease. As cancer therapuetics, the compounds of the invention may be used, e. g. , in combination with cytotoxic agents and/or radiation.
Antipicornaviral Compounds And Compositions, Their Pharmaceutical Uses, And Materials For Their Synthesis
Peter Scott Dragovich - Encinitas CA Stephen Evan Webber - San Diego CA Thomas Jay Prins - Cardiff CA Ru Zhou - Carlsbad CA Joseph Timothy Marakovits - Encinitas CA
Assignee:
Agouron Pharmaceuticals, Inc. - San Diego CA
International Classification:
C07K 506
US Classification:
514 19, 514351, 514378, 514423, 546329, 548248
Abstract:
Peptido and peptidomimetic compounds of the formula: wherein the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also provided.
Antipicornaviral Compounds And Compositions, Their Pharmaceutical Uses, And Materials For Their Synthesis
Peter Scott Dragovich - Encinitas CA Ru Zhou - Carlsbad CA Stephen Evan Webber - San Diego CA Thomas J. Prins - Cardiff CA Siegfried Heinz Reich - Solana Beach CA Susan E. Kephart - San Diego CA Yuanjin Rui - San Diego CA
Assignee:
Agouron Pharmaceuticals, Inc. - San Diego CA
International Classification:
A61K 31427
US Classification:
514365, 514367, 548180, 548200
Abstract:
Compounds of the formula: where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.
Tricyclic Inhibitors Of Poly(Adp-Ribose) Polymerases
Stephen Evan Webber - San Diego CA Donald James Skalitzky - San Diego CA Jayashree Girish Tikhe - San Diego CA Robert Arnold Kumpf - Encinitas CA Joseph Timothy Marakovits - Encinitas CA Brian Walter Eastman - San Diego CA
Assignee:
Agouron Pharmaceuticals, Inc. - San Diego CA
International Classification:
C07D48706
US Classification:
514220, 540496, 540499
Abstract:
Compounds of the formula shown below are poly(ADP-ribosyl)transferase inhibitors: Such compounds are useful as therapeutics in treating cancers and in ameliorating the effects of stroke, head trauma, and neurodegenerative disease.
Antipicornaviral Compounds, Their Preparation And Use
Peter Scott Dragovich - San Diego CA, US Stephen Evan Webber - San Diego CA, US Thomas Jay Prins - Cardiff CA, US Ru Zhou - Carlsbad CA, US Joseph Timothy Marakovits - Encinitas CA, US Jayashree Girish Tikhe - San Diego CA, US
Assignee:
Agouron Pharmaceuticals, Inc. - San Diego CA
International Classification:
C07D207/00
US Classification:
548416, 560128, 548534, 562553
Abstract:
Peptido and peptidomimetic compounds of the formula: wherein the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also provided.
3-Β-D-Ribofuranosylthiazolo[4-5-D]Pyridimine Nucleosides And Uses Thereof
Devron R. Averett - Cardiff by the Sea CA, US Stephen E. Webber - San Diego CA, US Joseph R. Lennox - Cardiff by the Sea CA, US Erik J. Rueden - Santee CA, US
The invention is directed to 3-β-D-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and pharmaceutical compositions containing such compounds that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.
Hiv Protease Inhibitors, Compositions Containing The Same, Their Pharmaceutical Uses And Materials For Their Synthesis
Stacie S. Canan Koch - La Jolla CA, US Therese N. Alexander - San Diego CA, US Mark Barvian - Ann Arbor MI, US Gary Bolton - Ann Arbor MI, US Benjamin J. Burke - San Diego CA, US Tod Holler - Ann Arbor MI, US Tanya M. Jewell - Encinitas CA, US Vara Prasad Josyula - Ann Arbor MI, US David J. Kucera - Del Mar CA, US Maria Angelica Linton - San Diego CA, US Jeffrey J. Machak - Shelby Township MI, US Sean T. Murphy - Ypsilanti MI, US Siegfried H. Reich - Solana Beach CA, US Donald J. Skalitzky - San Diego CA, US John H. Tatlock - San Diego CA, US Michael D. Varney - Solana Beach CA, US Scott C. Virgil - San Diego CA, US Stephen E. Webber - San Diego CA, US Stephen T. Worland - Del Mar CA, US Michael Melnick - Ann Arbor MI, US
Assignee:
Agouron Pharmaceuticals, Inc. - San Diego CA
International Classification:
C07D277/06
US Classification:
548200
Abstract:
Compounds of the formula: where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.
Medical School Howard University College of Medicine Graduated: 1986
Procedures:
Arthrocentesis Hip/Femur Fractures and Dislocations Joint Arthroscopy Knee Arthroscopy Lower Leg/Ankle Fractures and Dislocations Shoulder Arthroscopy Shoulder Surgery Carpal Tunnel Decompression Hallux Valgus Repair Knee Replacement Lower Arm/Elbow/Wrist Fractures and Dislocations Spinal Cord Surgery Spinal Fusion Spinal Surgery Wound Care
Conditions:
Internal Derangement of Knee Internal Derangement of Knee Ligaments Rotator Cuff Syndrome and Allied Disorders Fractures, Dislocations, Derangement, and Sprains Hallux Valgus
Description:
Dr. Webber graduated from the Howard University College of Medicine in 1986. He works in Bowie, MD and 2 other locations and specializes in Orthopaedic Surgery and Orthopedic Sports Medicine. Dr. Webber is affiliated with Doctors Community Hospital, Medstar Southern Maryland Hospital Center and Providence Hospital.
Acuative
Field Service Technician Ii
United States Marine Corps Apr 1, 2009 - Jul 1, 2010
Section Leader and Training Supervisor
United States Marine Corps Jan 1, 2008 - Mar 1, 2009
Telecommunications Supervisor
United States Marine Corps Mar 1, 2007 - Dec 1, 2007
Telecommunications Technician
Education:
Lone Star College 2011 - 2013
Associates, Associate of Arts
Klein Forest High School
Lone Star College System
eFFECTOR Therapeutics, Inc. - San Diego, CA since Jun 2012
Research Fellow
Anadys Pharmaceuticals Inc. (Purchased by Roche 11/2011) Apr 2008 - Feb 2012
President's Fellow
Anadys Pharmaceuticals Jan 2007 - Mar 2008
VP, Discovery Cheimistry
Anadys Pharmaceuticals Jan 2004 - Dec 2006
Senior Director, Medicinal Chemistry
Anadys Pharmaceuticals, Inc. Mar 2001 - Dec 2004
Director, Medicinal Chemistry
Education:
University of Pennsylvania 1981 - 1986
Doctor of Philosophy (PhD), Chemistry
Philadelphia University 1977 - 1981
BS, Textile Chemistry
Skills:
Medicinal Chemistry Drug Discovery Organic Chemistry Patent Applications Budgets Structure Based Drug Design Management Project Leadership
Hall Fletcher Junior High School Asheville NC 1963-1966
Community:
Ron King, Linda Laney, Sharon Duncan, Sheila Honeycutt, Margaret Hill, Linda Davis, Constance Wilson, Barbara Earley, Susan Luther, Ray West, Spiro Aliferis
Stephen Webber, chairman of the Missouri Democratic Party, said: State Senator Chappelle-Nadals comments are indefensible. All sides need to agree that there is no room for suggestions of political violence in America and the Missouri Democratic Party will absolutely not tolerate calls for the a
Among the most outspoken proponents of changing that was state Rep. Stephen Webber, a Columbia Democrat who has sponsored the Missouri Nondiscrimination Act for years. On Tuesday, he lost out to Republican Caleb Rowden for a seat in the Missouri Senate.
Date: Nov 09, 2016
Category: U.S.
Source: Google
On the Trail: The 12 burning questions of Missouri's unpredictable election
Regardless of how Kander and Hawley fare, millennials are set to at least make a mark in the Missouri Senate. Both competitors in the 19th District Senate seat (Democrat Stephen Webber and Republican Caleb Rowden) were born in the 1980s. And Democrat John Rizzo and Republican Andrew Koenig, who wereBut its also possible that Democrats could win a seat in the Senate if Stephen Webber and Scott Sifton win their contests. And Democrats are cautiously optimistic that their candidates can help the party climb out of the superminority abyss.
of Missouri, Rep. Stephen Webber, D-Columbia, said he could not support a budget that includes retaliatory cuts and money for a commission to review the university systems rules and structure, which he said will amount to a witch hunt at the University of Missouri for the next six months.
Date: Apr 21, 2016
Category: U.S.
Source: Google
Democrats face tough slog in gaining ground from GOP in Missouri Legislature
In Boone County, state Rep. Stephen Webber, D-Columbia, will take on state Rep. Caleb Rowden, R-Columbia, for the open 19th district. The traditionally Democratic seat has been in Republican hands for the last eight years, but term-limited state Sen. Kurt Schaefer is running for Missouri attorney ge
Date: Apr 04, 2016
Category: U.S.
Source: Google
Texas State Representative creates a bill to revive the Texas-Texas A&M rivalry
ast year, Missouri Rep. Stephen Webber threatened to block Kansas-themed license plates from the state of Missouri unless Missouri and Kansas restarted their rivalry. The two schools stopped playing after Missouri left for the SEC and even though Missouri has tried to rekindle the rivalry, Kansas ha
Date: Jan 29, 2013
Category: Sports
Source: Google
Dave Spence, Candidate For Missouri Governor, Declines To Say Whether Akin ...
addressed whether Akin should remain in the race, at least one Republican candidate for the state legislature has backed Akin. Last week, Fred Berry, who is challenging state Rep. Stephen Webber (D-Columbia), donated to Akin's campaign after the "legitimate rape" remarks and called on others to do the same.
Date: Aug 30, 2012
Category: U.S.
Source: Google
How state lawmakers pump up pensions in ways you can't
"It's mind-blowing hypocrisy," says state Rep. Stephen Webber, a Democrat from Missouri. State lawmakers there meet for roughly five months a year and are paid slightly more on average than a state worker, but records show a typical lawmaker's pension averages 30% more than a state worker's. The rea
Date: Sep 23, 2011
Category: U.S.
Source: Google
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