Stephen J Weiss

US Patent:

20020015970, Feb 7, 2002

Filed:

Dec 15, 2000

Appl. No.:

09/738877

Inventors:

Richard Murray - Cupertino CA, US
Susan Watson - El Cerrito CA, US
Stephen Weiss - Ann Arbor MI, US
Richard Glynne - Palo Alto CA, US
Peter Hevezi - San Francisco CA, US

International Classification:

A61K051/00
C12Q001/68
G01N033/574
A61K039/395

US Classification:

435/007230, 435/006000, 424/001490, 424/178100

Abstract:

Described herein are methods that can be used for diagnosis of angiogenesis and angiogenic phenotypes. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate angiogenesis. Additionally, molecular targets (genes and their products) for therapeutic intervention in disorders associated with angiogenesis are described. Moreover, methods for using such molecular targets are described.

US Patent:

20020019330, Feb 14, 2002

Filed:

Dec 15, 2000

Appl. No.:

09/738873

Inventors:

Richard Murray - Cupertino CA, US
Susan Watson - El Cerrito CA, US
Stephen Weiss - Ann Arbor MI, US
Richard Glynne - Palo Alto CA, US
Peter Hevezi - San Francisco CA, US

International Classification:

A61K031/00
C12Q001/00
C12Q001/68
G01N033/574

US Classification:

514/001000, 435/004000, 435/006000, 435/007230

Abstract:

Described herein are methods that can be used for diagnosis of angiogenesis and angiogenic phenotypes. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate angiogenesis. Additionally, molecular targets (genes and their products) for therapeutic intervention in disorders associated with angiogenesis are described. Moreover, methods for using such molecular targets are described.

US Patent:

20040009494, Jan 15, 2004

Filed:

Nov 20, 2002

Appl. No.:

10/301330

Inventors:

Richard Murray - Cupertino CA, US
Susan Watson - El Cerrito CA, US
Stephen Weiss - Ann Arbor MI, US
Richard Glynne - La Jolla CA, US
Peter Hevezi - San Francisco CA, US

International Classification:

C12Q001/68
G01N033/53
G01N033/567

US Classification:

435/006000, 435/007200

Abstract:

Described herein are methods that can be used for diagnosis of angiogenesis and angiogenic phenotypes. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate angiogenesis. Additionally, molecular targets (genes and their products) for therapeutic intervention in disorders associated with angiogenesis are described. Moreover, methods for using such molecular targets are described.

US Patent:

20040259152, Dec 23, 2004

Filed:

Aug 5, 2003

Appl. No.:

10/470576

Inventors:

Richard Murray - Cupertino CA, US
Susan Watson - El Cerrito CA, US
Stephen Weiss - Ann Arbor MI, US
Richard Glynne - Palo Alto CA, US
Peter Hevezi - San Francisco CA, US

International Classification:

G01N033/53
C12N015/85

US Classification:

435/007100, 435/455000

Abstract:

Described herein are methods that can be used for diagnosis of tissue remodeling, as well as tissue remodeling phenotypes. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate tissue remodeling. Additionally, molecular targets (genes and their products) for therapeutic intervention in disorders associated with tissue remodeling are described. Moreover, methods for using such molecular targets are described.

US Patent:

20090258006, Oct 15, 2009

Filed:

Apr 8, 2009

Appl. No.:

12/420649

Inventors:

STEPHEN WEISS - ANN ARBOR MI, US
ROBERT G. ROWE - ANN ARBOR MI, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF MICHIGAN - ANN ARBOR MI

International Classification:

A61K 39/395
A61K 31/7088
C12Q 1/02

US Classification:

4241301, 435 29, 514 44 R

Abstract:

The invention provides a method of inhibiting neovascularization in a subject. The method comprises administering to the subject an agent that interferes with fibronectin (Fn) matrix assembly in an amount effective to inhibit neovascularization. The invention also provides a method of identifying an agent that inhibits neovascularization. The method comprises detecting fibronectin (Fn) matrix assembly by stimulated endothelial cells cultured in three-dimensional culture gel in the presence and absence of an agent. A decrease in Fn matrix assembly in the presence of the agent compared to Fn matrix assembly in the absence of the agent is indicative of an agent that inhibits neovascularization. Alternatively, the method of identifying an agent that inhibits neovascularization comprises detecting changes in nuclear architecture in stimulated endothelial cells cultured in three-dimensional culture gel in the presence and absence of an agent. A reduction in nuclear architecture organization identifies an agent that inhibits neovascularization.

US Patent:

20100247512, Sep 30, 2010

Filed:

Apr 2, 2007

Appl. No.:

12/293984

Inventors:

Stephen Weiss - Ann Arbor MI, US
Tae-Hwa Chun - Ann Arbor MI, US

Assignee:

The Regents of the University of Michigan - Ann Arbor MI

International Classification:

A61K 38/46
A61P 3/00

US Classification:

424 9467

Abstract:

Methods are provided for regulating fat storage, carbohydrate metabolism and fatty acid synthesis using modulators of membrane type matrix metalloproteinase 1 (MT1-MMP).

US Patent:

20120294865, Nov 22, 2012

Filed:

May 18, 2012

Appl. No.:

13/474872

Inventors:

Stephen J. Weiss - Ann Arbor MI, US
David T. Dudley - Ann Arbor MI, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF MICHIGAN - Ann Arbor MI

International Classification:

A61K 39/395
C12N 15/13
C12N 15/63
C12P 21/02
C12N 1/21
A61P 9/00
C12N 1/19
C12N 5/09
G01N 33/566
C40B 30/04
A61P 35/00
A61P 43/00
C07K 16/28
C12N 5/10

US Classification:

4241401, 5303879, 5303897, 53038885, 5303873, 536 2353, 4353201, 435 696, 43525233, 4353441, 435419, 435414, 435412, 435415, 43525421, 4241741, 435375, 435 723, 506 9

Abstract:

The invention provides an integrin alpha-2 binding agent and methods of using an integrin alpha-2 binding agent to, e.g., inhibit proliferation of cancer cells, modulate tumor growth in a subject, inhibiting angiogenesis, or treating a fibrotic disorder. The invention further provides a method of producing an antibody, the method comprising propagating cancer cells in a 3-dimensional matrix; immunizing a mammal with the propagated cancer cells; and isolating an antibody from the immunized mammal. A method of identifying an agent that inhibits cancer cell proliferation also is provided.

Address:

3332 E Dobson Pl, Ann Arbor, MI 48105

Phone:

7346656671

VIN:

WUADU78E18N902091

Make:

AUDI

Model:

RS4

Year:

2008