Steve S Alexander

US Patent:

7399603, Jul 15, 2008

Filed:

Dec 18, 2003

Appl. No.:

10/740025

Inventors:

Jian Zheng - Raritan NJ, US
Steve Stanley Alexander - Flemington NJ, US

Assignee:

Ortho-Clinical Diagnostics, Inc. - Rochester NY

International Classification:

G01N 33/68

US Classification:

435 792, 435 693

Abstract:

In the present invention, we described the use of anti-DNA antibody for the detection of prions and diagnosis of Transmissible Spongiform Encephalopathies (TSE) diseases in animals and humans.

US Patent:

20090104181, Apr 23, 2009

Filed:

Jul 14, 2008

Appl. No.:

12/172787

Inventors:

Jian Zheng - Raritan NJ, US
Steve Stanley Alexander - Flemington NJ, US

International Classification:

A61K 39/395
G01N 33/53

US Classification:

4241301, 435 78

Abstract:

In the present invention, we described the use of anti-DNA antibody for the detection of prions and diagnosis of Transmissible Spongiform Encephalopathies (TSE) diseases in animals and humans.

US Patent:

61014230, Aug 8, 2000

Filed:

Jan 16, 1998

Appl. No.:

9/008070

Inventors:

Andrei Csipkes - Savage MD
Henry H. Yaffe - Baltimore MD
Steve B. Alexander - Millersville MD
Balakrishnan Sridhar - Elkridge MD
Dave A. Schwarten - Ellicott City MD
Yves Pradieu - Columbia MD

Assignee:

CIENA Corporation - Linthicum MD

International Classification:

G06F 1540

US Classification:

700117

Abstract:

The component parts for assembly of a device, such as the passive optical components of an optical amplifier, are automatically selected from among a supply of available component parts. Each component part has a performance parameter such as insertion loss associated therewith. Stored in a database memory are component part data for each component part of the supply of available component parts. The component part data are in a computer readable format and indicative of a type of each part and the performance parameter of each part. To obtain the selection of parts of the device for assembly, the component part data for a plurality of the available component parts is retrieved from the database, and the thus retrieved plurality of component part data are sorted according to at least the performance parameter of each retrieved component part data. At least one component part among the sorted component part data is selected based on a preset parameter. Then, at least one remaining component part among the sorted component part data is identified based at least on the performance parameter of the at least one component part and the performance parameter of the at least one remaining component part.

US Patent:

53647572, Nov 15, 1994

Filed:

Dec 11, 1991

Appl. No.:

7/805437

Inventors:

Robert F. Garry - New Orleans LA
Cesar D. Fermin - Mandeville LA
Steve S. Alexander - Gaithersburg MD

Assignee:

Administrators of the Tulane Educational Fund - New Orleans LA

International Classification:

C12Q 170
C12Q 100
G01N 33564
G01N 3353

US Classification:

435 5

Abstract:

The present invention relates to the discovery of a novel retroviral particle associated with autoimmune disease. New methods of diagnosis and treatment of autoimmune disease, novel cell lines comprising the new retrovirus, assay systems that may be used in the development of antiretroviral pharmaceuticals, and model systems for the study of autoimmune diseases and acquired immunodeficiency syndrome (AIDS) are provided by the present invention.

US Patent:

53447743, Sep 6, 1994

Filed:

Feb 23, 1993

Appl. No.:

8/021180

Inventors:

Robert F. Garry - New Orleans LA
Cesar D. Fermin - Mandeville LA
Steve S. Alexander - Gaithersburg MD

Assignee:

The Administrators of the Tulane Educational Fund - New Orleans LA

International Classification:

C12N 702
C12N 508
C12N 700
C12N 500

US Classification:

435239

Abstract:

The present invention relates to purified preparations of a novel retrovirus, to methods of diagnosis and treatment of Sjogren's syndrome, novel cell lines, and model systems for the study of autoimmune diseases and AIDS. It is based, in part, on the discovery of a novel retrovirus which is antigenically similar to human immunodeficiency virus but which appears to comprise a functionally distinct reverse transcriptase. According to the present invention, Sjogren's syndrome as well as other autoimmune diseases, may be diagnosed, and their clinical course may be monitored, by demonstrating the presence of anti-retroviral antibodies and/or measuring the levels of such antibodies. Alternatively, Sjogren's syndrome or other autoimmune diseases may be diagnosed or monitored by directly or indirectly demonstrating vital particles in the cells of a patient. Furthermore, according to the invention, Sjogren's patients who have been found to exhibit retrovirus or anti-retroviral antibodies may be treated with agents known to be useful in the treatment of retroviral diseases, including but not limited to, agents which interfere with reverse transcriptase function, such as, for example, nucleoside analogues (e. g.