Steve C Chang

US Patent:

6444859, Sep 3, 2002

Filed:

Aug 8, 2001

Appl. No.:

09/924573

Inventors:

Christopher Bieniarz - Highland Park IL
Steve H. Chang - Gurnee IL
Keith R. Cromack - Lake Bluff IL
Shuyen L. Huang - Riverwoods IL
Toshikazu Kawai - Saitama, JP
Manami Kobayashi - Saitama, JP
David Loffredo - Elmnurst IL
Rajagopalan Raghavan - Grayslake IL
Earl R. Speicher - Buffalo Grove IL
Honorate A. Stelmach - Lake Forest IL

Assignee:

Abbott Laboratories - Abbott Park IL
Central Glass Company LTD - Tokyo

International Classification:

C07C 4312

US Classification:

568683, 514722, 514816

Abstract:

The present invention relates to an anesthetic composition containing a fluoroether compound and a physiologically acceptable Lewis acid inhibitor. This composition exhibits improved stability and does not readily degrade in the presence of a Lewis acid.

US Patent:

6461874, Oct 8, 2002

Filed:

Jan 26, 2000

Appl. No.:

09/491139

Inventors:

Wei-Chao Ni - Foxboro MA
Daniel W. Eustace - North Attleboro MA
Steve Chin-Shen Chang - Franklin MA

Assignee:

Bayer Corporation - East Walpole MA

International Classification:

G01N 33553

US Classification:

436526, 436531, 436534, 436810, 436548, 435 79, 435188, 435963, 435176, 435180, 427414, 427337, 427338, 427222, 427 2, 428403, 428407, 530815

Abstract:

It has been found that casein and salts of casein are useful as replacements for, or in addition to, BSA as materials for coating solid phases, particularly magnetic particles, used in immunoassays and other binding assays for separation of the desired analyte. By using casein, immunoassays having improved stability and fewer discordant samples have been developed. Casein used at a concentration of 0. 05-4. 0 grams per gram of paramagnetic particle (optimally approximately 0. 78-1. 2 grams of casein per gram of magnetic particle) has been found to confer this benefit.

US Patent:

6677492, Jan 13, 2004

Filed:

Jul 3, 2002

Appl. No.:

10/190271

Inventors:

Christopher Bieniarz - Highland Park IL
Steve H. Chang - Gurnee IL
Keith R. Cromack - Lake Bluff IL
Shuyen L. Huang - Riverwoods IL
Toshikazu Kawai - Saitama, JP
Manami Kobayashi - Saitama, JP
David Loffredo - Elmhurst IL
Rajagopalan Raghavan - Grayslake IL
Earl R. Speicher - Buffalo Grove IL
Honorats A. Stelmach - Lake Forest IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C07C 4312

US Classification:

568683, 514722, 514816

Abstract:

The present invention relates to an anesthetic composition containing a fluoroether compound and a physiologically acceptable Lewis acid inhibitor. This composition exhibits improved stability and does not readily degrade in the presence of a Lewis acid.

US Patent:

6756234, Jun 29, 2004

Filed:

Dec 21, 2001

Appl. No.:

10/029541

Inventors:

Wei-Chao Ni - Foxboro MA
Daniel W. Eustace - North Attleboro MA
Steve Chin-Shen Chang - Franklin MA

Assignee:

Bayer Corporation - Tarrytown NY

International Classification:

G01N 33553

US Classification:

436526, 436531, 436534, 436810, 436548, 435 79, 435188, 435963, 435176, 435180, 427414, 427337, 427338, 427222, 427 2, 428403, 428407, 530815

Abstract:

It has been found that casein and salts of casein are useful as replacements for, or in addition to, BSA as materials for coating solid phases, particularly magnetic particles, used for immunoassays and other binding assays for separation of the desired analyte. By using casein, immunoassays having improved stability and few discordant samples have been developed. Casein used at a concentration of 0. 05-4. 0 grams per gram of paramagnetic particle (optimally approximately 0. 78-1. 2 grams of casein per gram of magnetic particle) has been found to confer this benefit. In addition, a process for coating solid phases has been invented, said process comprising the mixing of casein with magnetic particles at 30-60Â C. for 5-180 hours, said process resulting in casein-coated paramagnetic particles which either (1) already have combined therewith active ingredients needed in the binding assay or (2) are capable of reacting with active ingredients needed in the binding assay. Furthermore, a process for using the casein-coated paramagnetic particles have been developed, said particles being directly or indirectly combined with active ingredients used in the immunoassays.

US Patent:

20040048932, Mar 11, 2004

Filed:

Jun 26, 2003

Appl. No.:

10/606821

Inventors:

Christopher Bieniarz - Highland Park IL, US
Steve Chang - Gurnee IL, US
Keith Cromack - Lake Bluff IL, US
Shuyen Huang - Riverwoods IL, US
Toshikazu Kawai - Taurugashima, JP
Manami Kobayashi - Iruma-gun, JP
David Loffredo - Elmnurst IL, US
Rajagopalan Raghavan - Grayslake IL, US
Earl Speicher - Buffalo Grove IL, US
Honorate Stelmach - Lake Forest IL, US

International Classification:

A61K031/08

US Classification:

514/722000

Abstract:

The present invention relates to an anesthetic composition containing a fluoroether compound and a physiologically acceptable Lewis acid inhibitor. This composition exhibits improved stability and does not readily degrade in the presence of a Lewis acid.

US Patent:

20060148906, Jul 6, 2006

Filed:

Feb 27, 2006

Appl. No.:

11/362954

Inventors:

Christopher Bieniarz - Highland Park IL, US
Steve Chang - Gurnee IL, US
Keith Cromack - Lake Bluff IL, US
Shuyen Huang - Riverwoods IL, US
Toshikazu Kawai - Saitama, JP
Manami Kobayashi - Iruma-gun, JP
David Loffredo - Elmhurst IL, US
Rajagopalan Raghavan - Grayslake IL, US
Earl Speicher - Buffalo Grove IL, US
Honorata Stelmach - Lake Forest IL, US

International Classification:

A61K 31/08

US Classification:

514723000

Abstract:

The present invention relates to an anesthetic composition containing a fluoroether compound and a physiologically acceptable Lewis acid inhibitor. This composition exhibits improved stability and does not readily degrade in the presence of a Lewis acid.

US Patent:

59901764, Nov 23, 1999

Filed:

Jan 27, 1997

Appl. No.:

8/789679

Inventors:

Christopher Bieniarz - Highland Park IL
Steve H. Chang - Gurnee IL
Keith R. Cromack - Lake Bluff IL
Shuyen L. Huang - Riverwoods IL
Toshikazu Kawai - Tsurugashima, JP
Manami Kobayashi - Miyoshimachi, JP
David Loffredo - Elmhurst IL
Rajagopalan Raghavan - Grayslake IL
Earl R. Speicher - Buffalo Grove IL
Honorate A. Stelmach - Lake Forest IL

Assignee:

Abbott Laboratories - Abbott Park IL
Central Glass Company Ltd. - Tokyo

International Classification:

A61K 3108
C07C 4312

US Classification:

514722

Abstract:

The present invention relates to an anesthetic composition containing a fluoroether compound and a physiologically acceptable Lewis acid inhibitor. This composition exhibits improved stability and does not readily degrade in the presence of a Lewis acid.

US Patent:

62881272, Sep 11, 2001

Filed:

Nov 23, 1999

Appl. No.:

9/447853

Inventors:

Christopher Bieniarz - Highland Park IL
Steve H. Chang - Gurnee IL
Keith R. Cromack - Lake Bluff IL
Shuyen L. Huang - Riverwoods IL
Toshikazu Kawai - Saitama, JP
Manami Kobayashi - Saitama, JP
David Loffredo - Elmhurst IL
Rajagopalan Raghavan - Grayslake IL
Earl R. Speicher - Buffalo Grove IL
Honorate A. Stelmach - Lake Forest IL

Assignee:

Abbott Laboratories & Central Glass Co LTD - Abbott Park IL

International Classification:

A61K 3108
C07C 4312

US Classification:

514722

Abstract:

The present invention relates to an anesthetic composition containing a fluoroether compound and a physiologically acceptable Lewis acid inhibitor. This composition exhibits improved stability and does not readily degrade in the presence of a Lewis acid.