Steven Montgomery Baldwin

US Patent:

6630125, Oct 7, 2003

Filed:

Apr 30, 2001

Appl. No.:

09/844674

Inventors:

Timothy R. DeGrado - Durham NC
R. Edward Coleman - Durham NC
Steven W. Baldwin - Durham NC
David T. Price - Greenwood NC
Matthew D. Orr - Durham NC
Shuyan Wang - Durham NC

Assignee:

Duke University - Durham NC

International Classification:

A61K 5100

US Classification:

424 189

Abstract:

The present invention relates to F-labeled choline analogs and to methods of using same as imaging agents (for example, as positron emission tomography (PET) imaging agents) for the noninvasive detection and localization of neoplasms and pathophysiologies influencing choline processing in the body. The invention further relates to methods of synthesizing F-labeled choline analogs and to compositions comprising such analogs.

US Patent:

52623130, Nov 16, 1993

Filed:

Jun 14, 1991

Appl. No.:

7/715829

Inventors:

Barbara S. Kitchell - Austin TX
Robert W. Henkens - Durham NC
Philip Brown - Durham NC
Steven W. Baldwin - Durham NC
Charles H. Lochmuller - Durham NC
John P. O'Daly - Carrboro NC

Assignee:

Andcare, Inc. - Durham NC

International Classification:

C12P 762
C12P 764
C12N 1110
C12N 920

US Classification:

435135

Abstract:

Carrageenan-immobilized enzymes are prepared that are stable and retain high activity toward substrates when used in substantially water-immiscible organic solvents. The carrageenan-immobilized enzymes are preferably prepared by introducing droplets of an enzyme/carrageenan solution into a chilled alcohol saturated with a potassium salt and hardening the droplets in the alcohol. The alcohol is selected from n-butanol, benzyl alcohol, crotyl alcohol, n-propanol, isopropanol and sec-butanol. Reactions catalyzed by a. kappa. -carrageenan-immobilized esterase include steroselective transesterifications and hydrolysis reactions.