Steven L Bass

US Patent:

6541011, Apr 1, 2003

Filed:

Feb 10, 1999

Appl. No.:

09/247890

Inventors:

Juha Punnonen - Palo Alto CA
Steven H. Bass - Hillsborough CA
Robert Gerald Whalen - Paris, FR
Russell Howard - Los Altos Hills CA
Willem P. C. Stemmer - Los Gatos CA

Assignee:

Maxygen, Inc. - Redwood City CA

International Classification:

A61K 3912

US Classification:

4242041, 4242181, 530300, 530350

Abstract:

This invention is directed to antigen library immunization, which provides methods for obtaining antigens having improved properties for therapeutic and other uses. The methods are useful for obtaining improved antigens that can induce an immune response against pathogens, cancer, and other conditions, as well as antigens that are effective in modulating allergy, inflammatory and autoimmune diseases.

US Patent:

6569435, May 27, 2003

Filed:

Nov 28, 2000

Appl. No.:

09/724969

Inventors:

Juha Punnonen - Palo Alto CA
Steven H. Bass - Hillsborough CA
Robert Gerald Whalen - Paris, FR
Russell Howard - Los Altos Hills CA
Willem P. C. Stemmer - Los Gatos CA

Assignee:

Maxygen, Inc. - Redwood City CA

International Classification:

A61K 3912

US Classification:

4242021, 4242041, 4242361, 4242341, 4242741, 435 6, 4353201, 514 44

Abstract:

This invention is directed to antigen library immunization, which provides methods for obtaining antigens having improved properties for therapeutic and other uses. The methods are useful for obtaining improved antigens that can induce an immune response against pathogens, cancer, and other conditions, as well as antigens that are effective in modulating allergy, inflammatory and autoimmune diseases.

US Patent:

6576757, Jun 10, 2003

Filed:

Nov 28, 2000

Appl. No.:

09/724852

Inventors:

Juha Punnonen - Palo Alto CA
Steven H. Bass - Hillsborough CA
Robert Gerald Whalen - Paris, FR
Russell Howard - Los Altos Hills CA
Willem P. C. Stemmer - Los Gatos CA

Assignee:

Maxygen, Inc. - Redwood City CA

International Classification:

C07H 2104

US Classification:

536 2372, 536 231, 514 44, 4241841, 4242041, 4242181, 4242281

Abstract:

This invention is directed to antigen library immunization, which provides methods for obtaining antigens having improved properties for therapeutic and other uses. The methods are useful for obtaining improved antigens that can induce an immune response against pathogens, cancer, and other conditions, as well as antigens that are effective in modulating allergy, inflammatory and autoimmune diseases.

US Patent:

7462469, Dec 9, 2008

Filed:

May 23, 2002

Appl. No.:

10/154936

Inventors:

Steven H. Bass - Hillsborough CA, US
S. Christopher Davis - San Francisco CA, US
Phillip A. Patten - Menlo Park CA, US
Matthew Tobin - San Carlos CA, US
Jeremy Minshull - Los Altos CA, US
Mark Welch - Fremont CA, US
Claes Gustafsson - Belmont CA, US
Brian Carr - Raleigh NC, US
Stephane Jenne - Foster City CA, US
Sun Ai Raillard - Mountain View CA, US
Andreas Crameri - Mountain View CA, US
Willem P. C. Stemmer - Los Gatos CA, US
Robin Emig - Belmont CA, US
Pascal Longchamp - Allschwil, CH
Stanley Goldman - Walnut Creek CA, US
Lorraine J. Giver - Sunnyvale CA, US
Joseph A. Affholter - Lake Village Zephyr Cove NV, US

Assignee:

Maxygen, Inc. - Redwood City CA

International Classification:

C12P 19/34
C12Q 1/68

US Classification:

435 912, 435 6, 435 911

Abstract:

Integrated systems and methods for diversity generation and screening are provided. The systems use common fluid and array handling components to provide nucleic acid diversification, transcription, translation, product screening and subsequent diversification reactions.

US Patent:

7619067, Nov 17, 2009

Filed:

May 17, 2006

Appl. No.:

11/383798

Inventors:

Madan M. Paidhungat - San Francisco CA, US
Ian J. Sas - Redwood City CA, US
Thomas Bouquin - Kokkedal, DK
David Lin - Mountain View CA, US
Teddy Chen - San Diego CA, US
Douglas Guptill - Mountain View CA, US
Amy Brideau-Andersen - Irvine CA, US
Steven H. Bass - Hillsborough CA, US
Phillip A. Patten - Portola Valley CA, US

Assignee:

Maxygen, Inc. - Redwood City CA

International Classification:

C07K 14/52
C07K 14/00
A61K 38/21

US Classification:

530351, 530350, 530402, 424 857

Abstract:

The present invention provides evolved interferon-alpha polypeptides, and conjugates thereof, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.

US Patent:

7629170, Dec 8, 2009

Filed:

Aug 17, 2006

Appl. No.:

11/506215

Inventors:

Stephen delCardayre - Belmont CA, US
Matthew B. Tobin - San Carlos CA, US
Willem P. C. Stemmer - Los Gatos CA, US
Jon E. Ness - Redwood City CA, US
Jeremy S. Minshull - Los Altos CA, US
Phillip A. Patten - Menlo Park CA, US
Linda A. Castle - Mountain View CA, US
Claus M. Krebber - Palo Alto CA, US
Steven H. Bass - Hillsborough CA, US
Anthony R. Cox - Mountain View CA, US
Gjalt W. Huisman - San Carlos CA, US
Ling Yuan - El Marcero CA, US
Joseph A. Affholter - Zephyr Cove NV, US

Assignee:

Maxygen, Inc. - Redwood City CA

International Classification:

C12N 15/00
C12N 15/87
C12N 15/63

US Classification:

435440, 435455, 435463, 435464, 800 21

Abstract:

The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.

US Patent:

8014961, Sep 6, 2011

Filed:

Feb 21, 2007

Appl. No.:

11/677505

Inventors:

Steven H. Bass - Hillsborough CA, US
Simon Christopher Davis - San Francisco CA, US
Phillip A. Patten - Portola Valley CA, US
Matthew Tobin - San Carlos CA, US
Jeremy S. Minshull - Los Altos CA, US
Mark Welch - Fremont CA, US
Claus Gustafsson - Belmont CA, US
Brian Carr - Raleigh NC, US
Stephan J. Jenne - Foster City CA, US
Sun Ai Raillard - Mountain View CA, US
Andreas Crameri - Mountain View CA, US
Willem P. C. Stemmer - Los Gatos CA, US
Robin Emig - Belmont CA, US
Pascal Longchamp - Lausanne, CH
Stanley Goldman - Walnut Creek CA, US
Lorraine J. Giver - Sunnyvale CA, US
Joseph A. Affholter - Zephyr Cove NV, US

Assignee:

Codexis Mayflower Holdings, LLC - Redwood City CA

International Classification:

G01N 33/48

US Classification:

702 20

Abstract:

Integrated systems and methods for diversity generation and screening are provided. The systems use common fluid and array handling components to provide nucleic acid diversification, transcription, translation, product screening and subsequent diversification reactions.

US Patent:

8076138, Dec 13, 2011

Filed:

Oct 15, 2009

Appl. No.:

12/580056

Inventors:

Stephen DelCardayre - Belmont CA, US
Matthew B. Tobin - San Carlos CA, US
Willem P. C. Stemmer - Los Gatos CA, US
Jon E. Ness - Redwood City CA, US
Jeremy S. Minshull - Los Altos CA, US
Phillip A. Patten - Menlo Park CA, US
Linda A. Castle - Mountain View CA, US
Claus M. Krebber - Palo Alto CA, US
Steven H. Bass - Hillsborough CA, US
Anthony R. Cox - Mountain View CA, US
Gjalt W. Huisman - San Carlos CA, US
Ling Yuan - El Marcero CA, US
Joseph A. Affholter - Zephyr Cove CA, US

Assignee:

Codexis Mayflower Holdings, LLC - Redwood City CA

International Classification:

C12N 15/00
C12N 15/87
C12N 15/63

US Classification:

435440, 435455, 435463, 435464, 800 21

Abstract:

The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.