Steven B Clark

US Patent:

6348191, Feb 19, 2002

Filed:

Jun 17, 1991

Appl. No.:

07/704578

Inventors:

Steven C. Clark - Winchester MA
Gordon G. Wong - Jamaica Plain MA
Paul Schendel - Wayland MA
John McCoy - Reading MA

Assignee:

Genetics Institute, Inc. - Cambridge MA

International Classification:

A61K 3820

US Classification:

424 852, 514 2, 514 8, 514 12, 530351, 435 6952, 435 711, 435 712, 435325, 4352523, 43525411, 435471, 4353201

Abstract:

IL-6 is produced via recombinant DNA techniques. The peptide is useful in the treatment of disorders characterized by deficiencies in hematopoietic cells and in combination with other hematopoietins in cancer therapies.

US Patent:

6433142, Aug 13, 2002

Filed:

Sep 10, 1991

Appl. No.:

07/757022

Inventors:

Katherine Turner - Melrose MA
Steven C. Clark - Winchester MA
Kenneth Jacobs - Newton MA
Rodney M. Hewick - Lexington MA
Thomas G. Gesner - Richmond CA

Assignee:

Genetics Institute, LLC - Cambridge MA

International Classification:

C07K 1452

US Classification:

530351, 514 2

Abstract:

Novel human megakaryocyte stimulating factors (MSFS) capable of stimulating the growth and development of colonies of megakaryocytes, pharmaceutical compositions containing same, and methods for their preparation and use are provided.

US Patent:

7030223, Apr 18, 2006

Filed:

Apr 16, 2002

Appl. No.:

10/124557

Inventors:

Katherine Turner - Melrose MA, US
Steven C. Clark - Winchester MA, US
Kenneth Jacobs - Newton MA, US
Rodney M. Hewick - Lexington MA, US
Thomas G. Gesner - Richmond CA, US

Assignee:

Genetics Institute LLC - Cambridge MA

International Classification:

C07K 14/475
C07K 14/47
C12N 15/12
C12P 21/02

US Classification:

530351, 530350, 514 2, 514 12, 435 691, 435 695, 4353201, 435325

Abstract:

Novel polypeptides of human megakaryocyte stimulating factors (MSFs). Pharmaceutical compositions containing same, and methods for their preparation and use are provided.

US Patent:

7506041, Mar 17, 2009

Filed:

Aug 1, 2003

Appl. No.:

10/632098

Inventors:

James Shelton - Cooper City FL, US
Steven Clark - Parkland FL, US

Assignee:

Avocent Corporation - Huntsville AL

International Classification:

G06F 15/173

US Classification:

709223, 709229, 709227, 726 3

Abstract:

A method and apparatus for securely managing managed appliances such as keyboard/video/mouse (KVM) switches using a network communication protocol is described. A client workstation initiates a management session by establishing a secure sockets layer connection with the appliance over a predefined TCP port number. This secure management protocol is used to manage appliances that support SNMP by tunneling SNMP protocol requests through the presently-described protocol. The protocol includes a login sequence to enhance the security of data transmitted according to the protocol. The workstation can read and set object identifiers in the managed appliance. The workstation can also read and write files to and from the managed appliance. In addition, a single managed appliance can have multiple management sessions open at one time.

US Patent:

7622630, Nov 24, 2009

Filed:

Aug 27, 2004

Appl. No.:

10/570116

Inventors:

Joerg Heyer - Cambridge MA, US
Murray Robinson - Boston MA, US
William Rideout, III - Cambridge MA, US
Ronald Depinho - Brookline MA, US
Steven C. Clark - Winchester MA, US
Yinghui Zhou - Belmont MA, US
Tyler Jacks - West Newton MA, US
Ronan C. O'Hagan - Arlington MA, US

Assignee:

AVEO Pharmaceuticals, Inc. - Cambridge MA

International Classification:

C12N 15/00
A01K 67/00
C12N 5/06

US Classification:

800 25, 800 10, 800 18, 435354

Abstract:

Chimeric nonhuman mammals useful as inducible spontaneous cancer models are disclosed. The nonhuman mammals are obtained by introducing one or more genetically modified embryonic stem (ES) cells into an early stage embryo, and then implanting the manipulated embryo into a surrogate mother. The ES cells contain a recombinant oncogene, and also may contain a genetic mutation that deletes or inactivates a tumor suppressor gene. Models of different types of cancer are produced by introducing different combinations of genetic mutations into the ES cells that are introduced into the early stage embryo.

US Patent:

7361738, Apr 22, 2008

Filed:

Jun 28, 2005

Appl. No.:

11/169232

Inventors:

Katherine Turner - Melrose MA, US
Steven C. Clark - Winchester MA, US
Kenneth Jacobs - Newton MA, US
Rodney M. Hewick - Lexington MA, US
Thomas G. Gesner - Richmond CA, US

Assignee:

Genetics Institute, Inc. - Cambridge MA

International Classification:

C07K 14/47
C12N 15/10
C12P 21/02

US Classification:

530351, 530350, 435 691, 435 711, 4353201, 435471, 536 235

Abstract:

Novel polypeptides of human megakaryocyte stimulating factors (MSFs). Pharmaceutical compositions containing same, and methods for their preparation and use are provided.

US Patent:

20060198789, Sep 7, 2006

Filed:

Jan 6, 2006

Appl. No.:

11/326795

Inventors:

Zhigang Weng - Brookline MA, US
Jeno Gyuris - Winchester MA, US
Steven Clark - Winchester MA, US

International Classification:

A61K 49/00
C12Q 1/68
C12N 5/08
C12N 15/87

US Classification:

424009200, 435006000, 435455000, 435366000

Abstract:

An method of determining whether a gene of interest is necessary for a tumor cell to maintain its tumorigenicity is disclosed. The method is useful for validation of cancer therapeutic targets in vivo, using shRNAs and tumor xenografts. The inducible shRNA method operates an in vivo RNAi competition assay.

US Patent:

20140025968, Jan 23, 2014

Filed:

Sep 30, 2011

Appl. No.:

13/877513

Inventors:

Bharat A. Khuti - Hntsville AL, US
Steven Geffin - Miami FL, US
Richard Williams - Huntsville AL, US
Joe Kutner - Owens Cross Roads AL, US
Sheldon Altman - New Haven CT, US
Brian Williams - Stamford CT, US
Juarez Carvalho - Boca Raton FL, US
Michael Browner - Lauderhill FL, US
Mitesh Patel - Coral Springs FL, US
Kenneth L. Harper - Coral Springs FL, US
James H. Shelton - Cooper City FL, US
Steven Clark - Parkland FL, US
Donald A. Sturgeon - Huntsville AL, US
David John Cowen - Plantation FL, US
Mark Kershner - Huntsville AL, US
Steven R. Blackwell - Harvest AL, US
Karl Mills - Lynnwood WA, US
Yang Pu - Shenzhen, CN
Dai Jun - Shenzhen, CN
Richard M. Tobin - Marysville OH, US
Aman Khan - Bethel CT, US
Roy D. Pestone - Mount Vernon NY, US
Jean-Maxime Lachapelle - Coral Springs FL, US

Assignee:

AVOCENT HUNTSVILLE CORP. - Huntsville AL

International Classification:

G06F 1/32

US Classification:

713320

Abstract:

A system for monitoring, controlling and optimizing power usage and cooling utilization within a data center infrastructure. The system may make use of a subsystem which is adapted to obtain real time information on both facility devices and information technology (IT) devices. The subsystem may be used to evaluate the real time information to provide an alert and diagnostic information with respect to at least one of the facility devices or at least one of the IT devices. The subsystem may also make use of a mechanism that provides real time control over at least one of the facility devices or at least one of the IT devices to optimize at least one of cooling utilization, power usage or performance of at least one of the facility devices or at least one of the IT devices.