Steven R Clark

US Patent:

6348191, Feb 19, 2002

Filed:

Jun 17, 1991

Appl. No.:

07/704578

Inventors:

Steven C. Clark - Winchester MA
Gordon G. Wong - Jamaica Plain MA
Paul Schendel - Wayland MA
John McCoy - Reading MA

Assignee:

Genetics Institute, Inc. - Cambridge MA

International Classification:

A61K 3820

US Classification:

424 852, 514 2, 514 8, 514 12, 530351, 435 6952, 435 711, 435 712, 435325, 4352523, 43525411, 435471, 4353201

Abstract:

IL-6 is produced via recombinant DNA techniques. The peptide is useful in the treatment of disorders characterized by deficiencies in hematopoietic cells and in combination with other hematopoietins in cancer therapies.

US Patent:

6433142, Aug 13, 2002

Filed:

Sep 10, 1991

Appl. No.:

07/757022

Inventors:

Katherine Turner - Melrose MA
Steven C. Clark - Winchester MA
Kenneth Jacobs - Newton MA
Rodney M. Hewick - Lexington MA
Thomas G. Gesner - Richmond CA

Assignee:

Genetics Institute, LLC - Cambridge MA

International Classification:

C07K 1452

US Classification:

530351, 514 2

Abstract:

Novel human megakaryocyte stimulating factors (MSFS) capable of stimulating the growth and development of colonies of megakaryocytes, pharmaceutical compositions containing same, and methods for their preparation and use are provided.

US Patent:

6445844, Sep 3, 2002

Filed:

Dec 21, 1999

Appl. No.:

09/446540

Inventors:

Armand P. Neukermans - Palo Alto CA
Timothy G. Slater - San Francisco CA
Tyler L. Baughman - Campbell CA
James P. Downing - Saratoga CA
John S. Forker - Palo Alto CA
Gregory A. Reznick - Pleasanton CA
Sam Calmes - Mountain View CA
Steven M. Clark - Palo Alto CA
Jack D. Foster - Los Altos CA
Marc R. Schuman - San Francisco CA
Rajiv Ramaswami - Yorktown Heights NY

Assignee:

XROS, Inc. - Santa Clara CA

International Classification:

G02B 635

US Classification:

385 18, 385 17, 385 33

Abstract:

A fiber optic switch includes a fiber optic switching module that receives and fixes ends of optical fibers. The module includes numerous reflective light beam deflectors which may be selected as pairs for coupling a beam of light between a pair of optical fibers. The module also produces orientation signals from each deflector which indicate its orientation. A portcard included in the switch supplies drive signals to the module for orienting at least one deflector. The portcard also receives the orientation signals produced by that deflector together with coordinates that specify an orientation for the deflector. The portcard compares the received coordinates with the orientation signals received from the deflector and adjusts the drive signals supplied to the module to reduce any difference between the received coordinates and the orientation signals. The switch also employs optical alignment to precisely orient pairs of deflectors coupling a beam of light between optical fibers.

US Patent:

6555658, Apr 29, 2003

Filed:

Aug 9, 2001

Appl. No.:

09/924703

Inventors:

Giorgio Trinchieri - Wynnewood PA
Bice Perussia - Philadelphia PA
Steven C. Clark - Winchester MA
Gordon G. Wong - Jamaica Plain MA
Rodney Hewick - Lexington MA
Michiko Kobayashi - Brookline MA

Assignee:

Wyeth - Madison NJ
The Wistar Institute - Philadelphia PA

International Classification:

C07K 1624

US Classification:

5303881, 53038823

Abstract:

This application relates to antibodies reactive with a novel homogenous human cytokine, Natural Killer Stimulator Factor (NKSF), having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing such antibodies.

US Patent:

6592735, Jul 15, 2003

Filed:

Dec 22, 2000

Appl. No.:

09/746339

Inventors:

Joseph T. Meier - So. Pasadena CA
Steven M. Clark - Palo Alto CA
Charles F. Spence - Arcadia CA

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

G01N 2726

US Classification:

204621, 204616, 204617, 204618

Abstract:

A machine for sequencing DNA using optical techniques. A sample is loaded in the sample loading area, and place through DNA sequencing gel. The voltage across the reservoir may be increased by improving the cooling and thermal characteristics of the gel device. Preferably materials are used which have at least half and preferably a fifth the thermal transfer characteristics of glass. The materials can also be thin e. g. 50-100 microns. A heat sink can be used to dissipate more of the heat, and a fan can be directed at the heat sink. Moreover, the material can be flexible.

US Patent:

6694072, Feb 17, 2004

Filed:

Jan 11, 2002

Appl. No.:

10/031159

Inventors:

Armand P. Neukermans - Portola Valley CA 94028
Steven M. Clark - Palo Alto CA 94306
Marc R. Schuman - San Francisco CA 94122
Timothy G. Slater - San Francisco CA 94110
Jack D. Foster - Los Altos CA 94024
Sam Calmes - Mountain View CA 95070

International Classification:

G02B 626

US Classification:

385 18, 385 16

Abstract:

A fiber optic switch ( ) includes a fiber optic switching module ( ) that receives and fixes ends ( ) of optical fibers ( ). The module ( ) includes numerous reflective light beam deflectors ( ) arranged in a V-shape which may be selected as pairs for coupling a beam of light ( ) between a pair of optical fibers ( ). The module ( ) also produces orientation signals from each deflector ( ) which indicate its orientation. A portcard ( ) supplies drive signals to the module ( ) for orienting at least one deflector ( ). The portcard ( ) also receives the orientation signals produced by that deflector ( ) together with coordinates that specify an orientation for the deflector ( ). The portcard ( ) compares the received coordinates with the orientation signals and adjusts the drive signals supplied to the module ( ) to reduce any difference between the received coordinates and the orientation signals. The switch ( ) also employs optical alignment to precisely orient pairs deflectors ( ) coupling a beam of light ( ) between optical fibers ( ).

US Patent:

6795602, Sep 21, 2004

Filed:

Dec 1, 2000

Appl. No.:

09/729336

Inventors:

Armand P. Neukermans - Palo Alto CA 94303
Timothy G. Slater - San Francisco CA 94110
Tyler L. Baughman - Campbell CA 95088
James P. Downing - Saratoga CA 95070
John S. Forker - Palo Alto CA 94301
Gregory A. Reznick - Pleasanton CA 94566
Sam Calmes - Mountain View CA 95070
Steven M. Clark - Palo Alto CA 94303
Jack D. Foster - Los Altos CA 94024
Marc R. Schuman - San Francisco CA 94122
Rajiv Ramaswami - Yorktown Heights NY 10598

International Classification:

G02B 635

US Classification:

385 18

Abstract:

A fiber optic switch ( ) includes a fiber optic switching module ( ) that receives and fixes ends ( ) of optical fibers ( ). The module ( ) includes numerous reflective light beam deflectors ( ) which may be selected as pairs for coupling a beam of light ( ) between a pair of optical fibers ( ). The module ( ) also produces orientation signals from each deflector ( ) which indicate its orientation. A portcard ( ) included in the switch ( ) supplies drive signals to the module ( ) for orienting at least one deflector ( ). The portcard ( ) also receives the orientation signals produced by that deflector ( ) together with coordinates that specify an orientation for the deflector ( ). The portcard ( ) compares the received coordinates with the orientation signals received from the deflector ( ) and adjusts the drive signals supplied to the module ( ) to reduce any difference between the received coordinates and the orientation signals. The switch ( ) also employs optical alignment to precisely orient pairs deflectors ( ) coupling a beam of light ( ) between optical fibers ( ).

US Patent:

6866461, Mar 15, 2005

Filed:

Feb 25, 2003

Appl. No.:

10/375507

Inventors:

Scott M. DeWinter - Oakland CA, US
John B. Rusconi - Dublin CA, US
Steven M. Clark - Palo Alto CA, US
Michael P. Lucas - Milpitas CA, US
Michael G. Youngquist - Palo Alto CA, US

Assignee:

Ciphergen Biosystems, Inc. - Fremont CA

International Classification:

B65G065/00

US Classification:

41422207, 422 63

Abstract:

The present invention comprises a loading device for automating transfer of a plurality of probes between a cassette within which the plurality of probes are initially constrained and an analytical instrument, e. g. , mass spectrometer. The loading device may be configured to accept a single or a plurality of cassettes each removably constraining a plurality of probes to be analyzed. The loading device may permit each of the plurality of cassettes to be independently interchanged with a separate cassette removably constraining a separate plurality of probes during mass spectrometric analysis, or for additional cassettes to be loaded into the device during analysis. In a useful embodiment, the loading device comprises a cassette transport assembly and a probe insertion assembly. The cassette transport assembly linearly translates one or more cassettes to align the cassette(s) with respect to the mass spectrometer so that a probe may be translated therebetween by the probe insertion assembly. The probe insertion assembly also provides means to rotatably engage said probe.