Ee Lui Ang - Singapore, SG Oscar Alvizo - Fremont CA, US Behnaz Behrouzian - Sunnyvale CA, US Michael Clay - Menlo Park CA, US Steven Collier - Lexington MA, US Ellen Eberhard - Fallbrook CA, US Fan Jaslyn Fu - Singapore, SG Shiwei Song - Singapore, SG Derek Smith - Singapore, SG Magnus Widegren - Craigavon, GB Robert Wilson - San Francisco CA, US Junye Xu - Singapore, SG Jun Zhu - Chandler AZ, US
The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (−)-2-[(R)-(diphenyl-methyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (R)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.
Biocatalysts And Methods For The Synthesis Of Armodafinil
- Redwood City CA, US Oscar Alvizo - Fremont CA, US Behnaz Behrouzian - Sunnyvale CA, US Michael D. Clay - Menlo Park CA, US Steven J. Collier - Concord MA, US Ellen D. Eberhard - Fallbrook CA, US Fu Fan - Singapore, SG Shiwei Song - Singapore, SG Derek J. Smith - Singapore, SG Magnus Widegren - Craigavon, GB Robert Wilson - Meldreth, GB Junye Xu - Singapore, SG Jun Zhu - Chandler AZ, US
International Classification:
C12N 9/02 C12P 11/00 C12P 41/00 C12P 13/02
Abstract:
The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (−)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (R)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.
- Redwood City CA, US Oscar Alvizo - Fremont CA, US Behnaz Behrouzian - Sunnyvale CA, US Yong Koy Bong - Singapore, SG Steven J. Collier - Concord MA, US Anupam Gohel - Bekasi, ID Jagadeesh Mavinahalli - Maharashtra, IN Naga K. Modukuru - Singapore, SG Emily Mundorff - Garden City NY, US Derek J. Smith - Singapore, SG Shiwei Song - Singapore, SG Wan Lin Yeo - Singapore, SG
International Classification:
C12N 9/04 C07K 14/47 C12P 17/10
Abstract:
The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
Biocatalysts And Methods For The Synthesis Of Armodafinil
- Redwood City CA, US Oscar Alvizo - Fremont CA, US Behnaz Behrouzian - Sunnyvale CA, US Michael D. Clay - Menlo Park CA, US Steven J. Collier - Concord MA, US Ellen D. Eberhard - Fallbrook CA, US Fu Fan - Singapore, SG Shiwei Song - Singapore, SG Derek J. Smith - Singapore, SG Magnus Widegren - Craigavon, GB Robert Wilson - San Francisco CA, US Junye Xu - Singapore, SG Jun Zhu - Chandler AZ, US
International Classification:
C12N 9/02 C12P 11/00 C12P 41/00 C12P 13/02
Abstract:
The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (−)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (R)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.
- Redwood City CA, US Oscar Alvizo - Fremont CA, US Behnaz Behrouzian - Sunnyvale CA, US Yong Koy Bong - Singapore, SG Steven J. Collier - Concord MA, US Anupam Gohel - Bekasi, ID Jagadeesh Mavinahalli - Maharashtra, IN Naga K. Modukuru - Singapore, SG Emily Mundorff - Garden City NY, US Derek J. Smith - Singapore, SG Shiwei Song - Singapore, SG Wan Lin Yeo - Singapore, SG
International Classification:
C12N 9/04 C12P 17/10 C07K 14/47
Abstract:
The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
Biocatalysts And Methods For The Synthesis Of Armodafinil
- REDWOOD CITY CA, US Oscar Alvizo - Fremont CA, US Behnaz Behrouzian - Sunnyvale CA, US Michael D. Clay - Menlo Park CA, US Steven J. Collier - Concord MA, US Ellen D. Eberhard - Fallbrook CA, US Fu Fan - Singapore, SG Shiwei Song - Singapore, SG Derek J. Smith - Singapore, SG Magnus Widegren - Craigavon, GB Robert Wilson - San Francisco CA, US Junye Xu - Singapore, SG Jun Zhu - Chandler AZ, US
International Classification:
C12N 9/02 C12P 11/00 C12P 41/00 C12P 13/02
Abstract:
The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (−)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (R)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.
Biocatalysts And Methods For The Synthesis Of Armodafinil
- Redwood City CA, US Oscar Alvizo - Fremont CA, US Behnaz Behrouzian - Sunnyvale CA, US Michael D. Clay - Menlo Park CA, US Steven J. Collier - Concord MA, US Ellen D. Eberhard - Fallbrook CA, US Fu Fan - Singapore, SG Shiwei Song - Singapore, SG Derek J. Smith - Singapore, SG Magnus Widegren - Craigavon, GB Robert Wilson - San Francisco CA, US Junye Xu - Singapore, SG Jun Zhu - Chandler AZ, US
International Classification:
C12N 9/02 C12P 13/02 C12P 41/00 C12P 11/00
Abstract:
The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (−)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (R)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.
Biocatalysts And Methods For The Synthesis Of Armodafinil
- Redwood City CA, US Oscar Alvizo - Fremont CA, US Behnaz Behrouzian - Sunnyvale CA, US Michael D. Clay - Menlo Park CA, US Steven J. Collier - Concord MA, US Ellen D. Eberhard - Fallbrook CA, US Fu Fan - Singapore, SG Shiwei Song - Singapore, SG Derek J. Smith - Singapore, SG Magnus Widegren - Craigavon, GB Robert Wilson - San Francisco CA, US Junye Xu - Singapore, SG Jun Zhu - Chandler AZ, US
International Classification:
C12N 9/02 C12P 13/02 C12P 11/00 C12P 41/00
Abstract:
The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (−)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (R)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.
Name / Title
Company / Classification
Phones & Addresses
Mr. Steven P. Collier Partner
Connelly, Jackson & Collier, LLP Attorneys & Lawyers. Attorneys (Also See Lawyers)
405 Madison Avenue, Suite 2300, Toledo, OH 43604 4192432100, 4192437119
Nov 1993 to 2000Boeing Downey, CA Oct 1981 to Nov 1993 Member of the Technical Staff - M & P Test EngineerPratt & Whitney Canoga Park, CA Mar 1979 to Aug 1981 Member of the Technical Staff - Analytical ChemistOccidental Petroleum Corp
Aug 1978 to Dec 1979 Research Chemical TechnicianWilliam Thompson Co Carson, CA Aug 1978 to Mar 1979 Quality Control Chemist
Education:
University of California Irvine, CA Sep 1973 to Jun 1977 B.S. in Biological SciencesCalifornia State University Master's in Material ScienceUCLA engineering and computer science
2011 to 2000 Mathematics InstructorRiverside Community College
1993 to 2000 Adjunct Instructor and Computer Lab InstructorMt. San Jacinto College
1996 to 2002 Adjunct InstructorVarsity Coach Girls and Boys tennis 1989 to 1996Assistant Varsity Coach Wrestling 1986 to 1991Woodcrest Christian School Riverside, CA 1983 to 1986 Math teacher
White River Rural HealthArcare 400 Hwy 64 E, Augusta, AR 72006 8703472508 (phone), 8703475556 (fax)
Education:
Medical School University of Arkansas College of Medicine at Little Rock Graduated: 1980
Languages:
English Spanish
Description:
Dr. Collier graduated from the University of Arkansas College of Medicine at Little Rock in 1980. He works in Augusta, AR and specializes in Family Medicine. Dr. Collier is affiliated with North East Arkansas Baptist Memorial Hospital.
Austin, TXVP Business Development at Milsoft Utility Solutio... Past: VP Competitive Intelligence at National Rural Telecommunications Cooperative, President &... Born in Alamogordo, NM.
Grew up in Carlsbad, NM.
One sister, Denise, married to Dan Williams, living in Corona, NM.
6'4" tall. 190 lbs.
Married to Allison... Born in Alamogordo, NM.
Grew up in Carlsbad, NM.
One sister, Denise, married to Dan Williams, living in Corona, NM.
6'4" tall. 190 lbs.
Married to Allison Leigh Conley.
SEVEN CHILDREN! Rachel, Joel, Lori, Ginna, Zoe, twins Harper & Raine
One son-in-law, Mike Wheeler & two granddaughters, Victoria...
Bainbridge-Guilford High School Bainbridge NY 1989-1993
Community:
Bridget Winn, David Louden, Jessica Wright, Kristie Dietrich, Lisa Wayman, Christi Turtur, Scott Leach, Jessica Birdsall, Jennifer Hartwell, Robin Rusweiler, Franklin Devries