Steven Reed Collier

US Patent:

20200325510, Oct 15, 2020

Filed:

Jun 26, 2020

Appl. No.:

16/913761

Inventors:

- Redwood City CA, US
Yong Koy Bong - Singapore, SG
Fabien L. Cabirol - DUSSELDORF, DE
Anupam Gohel Prafulchandra - Bekasi, ID
Tao Li - Cincinnati OH, US
Jeffrey C. Moore - Westfield NJ, US
Martina Quintanar-Audelo - Edinburgh, GB
Yang Hong - Singapore, SG
Steven J. Collier - Concord MA, US
Derek Smith - Singapore, SG

International Classification:

C12P 17/12
C12P 17/18
C12N 9/02
C12P 13/24
C12P 13/04

Abstract:

The present disclosure provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.

US Patent:

20190323046, Oct 24, 2019

Filed:

Jun 20, 2019

Appl. No.:

16/446866

Inventors:

- Redwood City CA, US
Yong Koy Bong - Singapore, SG
Fabien L. Cabirol - DUSSELDORF, DE
Anupam Gohel Prafulchandra - Bekasi, ID
Tao Li - Cincinnati OH, US
Jeffrey C. Moore - Westfield NJ, US
Martina Quintanar-Audelo - Edinburgh, GB
Yang Hong - Singapore, SG
Steven J. Collier - Concord MA, US
Derek Smith - Singapore, SG

International Classification:

C12P 17/12
C12P 13/04
C12N 9/02
C12P 17/18
C12P 13/24

Abstract:

The present disclosure provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.

US Patent:

20170121744, May 4, 2017

Filed:

Nov 21, 2016

Appl. No.:

15/357668

Inventors:

- Redwood City CA, US
Yong Koy Bong - Singapore, SG
Fabien L. Cabirol - DUSSELDORF, DE
Anupam Gohel Prafulchandra - Bekasi, ID
Tao Li - Cincinnati OH, US
Jeffrey C. Moore - Westfield NJ, US
Martina Quintanar-Audelo - Edinburgh, GB
Yang Hong - Singapore, SG
Steven J. Collier - Concord MA, US
Derek Smith - Singapore, SG

International Classification:

C12P 13/24
C12N 9/02

Abstract:

The present disclosure provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.

US Patent:

20150118719, Apr 30, 2015

Filed:

May 7, 2013

Appl. No.:

14/399034

Inventors:

- Redwood City CA, US
Yong Koy Bong - Singapore, SG
Fabien L. Cabirol - Dusseldorf, DE
Anupam Gohel Prafulchandra - Bekasi, ID
Tao Li - Cincinnati OH, US
Jeffrey C. Moore - Westfield NJ, US
Martina Quintanar-Audelo - Edinburgh, GB
Yang Hong - Singapore, SG
Steven J. Collier - Concord MA, US
Derek Smith - Singapore, SG

International Classification:

C12P 17/12
C12P 13/24
C12P 13/04
C12N 9/02

US Classification:

435107, 435189, 536 232, 4353201, 43525233, 435122, 435119, 435106

Abstract:

The present disclosure provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents. The present disclosure provides engineered proline hydroxylase biocatalysts, polynucleotides encoding the biocatalysts. methods of their preparation, and processes for preparing hydroxylated compounds using these engineered biocatalysts.