- REDWOOD CITY CA, US John M. Gruber - El Dorado Hills CA, US Emily Mundorff - Garden City NY, US Gjalt W. Huisman - Redwood City CA, US Steven J. Collier - Concord MA, US
International Classification:
C12P 17/00 C12N 9/04 C12P 13/00
Abstract:
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N-methyl-3-keto-3-(2-thienyl)-1-propanamine to (S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine.
- Redwood City CA, US John M. Gruber - El Dorado Hills CA, US Emily Mundorff - Garden City NY, US Gjalt W. Huisman - Redwood City CA, US Steven J. Collier - Concord MA, US
International Classification:
C12P 17/00 C12N 9/04 C12P 13/00
Abstract:
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N-methyl-3-keto-3-(2-thienyl)-1-propanamine to (S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine.
- Redwood City CA, US John M. Gruber - El Dorado Hills CA, US Emily Mundorff - Garden City NY, US Gjalt W. Huisman - Redwood City CA, US Steven J. Collier - Concord MA, US
International Classification:
C12P 17/00 C12P 13/00 C12N 9/04
Abstract:
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N-methyl-3-keto-3-(2-thienyl)-1-propanamine to (S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine.
- Redwood City CA, US John M. Gruber - El Dorado Hills CA, US Emily Mundorff - Garden City NY, US Gjalt W. Huisman - Redwood City CA, US Steven J. Collier - Concord MA, US
International Classification:
C12P 17/00 C12P 13/00 C12N 9/04
Abstract:
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N-methyl-3-keto-3-(2-thienyl)-1-propanamine to (S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine.
- REDWOOD CITY CA, US John M. Gruber - El Dorado Hills CA, US Emily Mundorff - Garden City NY, US Gjalt W. Huisman - Redwood City CA, US Steven J. Collier - Concord MA, US
International Classification:
C12P 17/00 C12N 9/04
Abstract:
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N-methyl-3-keto-3-(2-thienyl)-1-propanamine to (S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine.
- Redwood City CA, US John M. Gruber - El Dorado Hills CA, US Emily Mundorff - Garden City NY, US Gjalt W. Huisman - Redwood City CA, US Steven J. Collier - Concord MA, US
International Classification:
C12P 13/00 C12N 9/04
US Classification:
435128, 435190, 43525233, 4353201, 536 232
Abstract:
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N-methyl-3-keto-3-(2-thienyl)-1-propanamine to (S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine.
Name / Title
Company / Classification
Phones & Addresses
Mr. Steven P. Collier Partner
Connelly, Jackson & Collier, LLP Attorneys & Lawyers. Attorneys (Also See Lawyers)
405 Madison Avenue, Suite 2300, Toledo, OH 43604 4192432100, 4192437119
Steven W. Collier Managing
Defensive Accuracy LLC Fire Arms Training · Ret Sporting Goods/Bicycles
White River Rural HealthArcare 400 Hwy 64 E, Augusta, AR 72006 8703472508 (phone), 8703475556 (fax)
Education:
Medical School University of Arkansas College of Medicine at Little Rock Graduated: 1980
Languages:
English Spanish
Description:
Dr. Collier graduated from the University of Arkansas College of Medicine at Little Rock in 1980. He works in Augusta, AR and specializes in Family Medicine. Dr. Collier is affiliated with North East Arkansas Baptist Memorial Hospital.
Austin, TXVP Business Development at Milsoft Utility Solutio... Past: VP Competitive Intelligence at National Rural Telecommunications Cooperative, President &... Born in Alamogordo, NM.
Grew up in Carlsbad, NM.
One sister, Denise, married to Dan Williams, living in Corona, NM.
6'4" tall. 190 lbs.
Married to Allison... Born in Alamogordo, NM.
Grew up in Carlsbad, NM.
One sister, Denise, married to Dan Williams, living in Corona, NM.
6'4" tall. 190 lbs.
Married to Allison Leigh Conley.
SEVEN CHILDREN! Rachel, Joel, Lori, Ginna, Zoe, twins Harper & Raine
One son-in-law, Mike Wheeler & two granddaughters, Victoria...
Bainbridge-Guilford High School Bainbridge NY 1989-1993
Community:
Bridget Winn, David Louden, Jessica Wright, Kristie Dietrich, Lisa Wayman, Christi Turtur, Scott Leach, Jessica Birdsall, Jennifer Hartwell, Robin Rusweiler, Franklin Devries