Steven M Collier

US Patent:

20130302859, Nov 14, 2013

Filed:

May 9, 2013

Appl. No.:

13/890944

Inventors:

CHEN Haibin - SG, SG
Steven J. Collier - Lexington MA, US
Jovana NAZOR - Santa Clara, US
Joly SUKUMARAN - SG, SG
Derek SMITH - Singapore, SG
Jeffrey C. MOORE - Westfield NJ, US
Gregory HUGHES - Scotch Plains NJ, US
Jacob JANEY - New York NY, US
Gjalt HUISMAN - San Carlos CA, US
Scott NOVICK - Palo Alto CA, US
Nicholas AGARD - San Francisco CA, US
Oscar ALVIZO - Freemont CA, US
Gregory COPE - Menlo Park CA, US
Wan Lin YEO - Singapore, SG
Stephanie NG - Redwood City CA, US

Assignee:

CODEXIS,INC. - Redwood City CA

International Classification:

C12N 9/00

US Classification:

435122, 435191, 536 232, 4353201, 435128, 435121, 4352523, 43525233, 43525231, 43525235, 43525411, 4352542, 43525421, 43525423, 435348, 435358, 435365, 435352, 435419

Abstract:

The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

US Patent:

20220315961, Oct 6, 2022

Filed:

Jun 2, 2022

Appl. No.:

17/830650

Inventors:

- Redwood City CA, US
Steven J. Collier - Concord MA, US
Jovana Nazor - Milpitas CA, US
Joly Sukumaran - Singapore, SG
Derek Smith - Singapore, SG
Jeffrey C. Moore - Westfield NJ, US
Gregory Hughes - Scotch Plains NJ, US
Jacob Janey - New York NY, US
Gjalt W. Huisman - Redwood City CA, US
Scott J. Novick - Palo Alto CA, US
Nicholas J. Agard - San Francisco CA, US
Oscar Alvizo - Fremont CA, US
Gregory A. Cope - Menlo Park CA, US
Wan Lin Yeo - Singapore, SG
Stefanie Ng Minor - Redwood City CA, US

International Classification:

C12P 13/02
C12P 13/00
C12P 17/18
C12P 13/04
C12P 13/06
C12P 17/10
C12P 17/12
C12P 17/16
C12N 9/06

Abstract:

The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

US Patent:

20220267744, Aug 25, 2022

Filed:

Apr 28, 2022

Appl. No.:

17/731635

Inventors:

- Redwood City CA, US
Steven J. Collier - Concord MA, US
Hans-Georg Joerg Hennemann - Bedburg, DE
Seong Ho Oh - Singapore, SG
Wenjuan Zha - Singapore, SG

International Classification:

C12N 9/04
A61K 31/137
C12P 13/00

Abstract:

The disclosure relates to engineered ketoreductase polypeptides and processes of using the polypeptides for production of phenylephrine.

US Patent:

20210348139, Nov 11, 2021

Filed:

Jul 19, 2021

Appl. No.:

17/379843

Inventors:

- Redwood City CA, US
Derek J. Smith - Singapore, SG
Michael A. Crowe - Singapore, SG
Shiwei Song - Singapore, SG
Steven J. Collier - Concord MA, US

International Classification:

C12N 9/10
C12P 17/10

Abstract:

The present disclosure provides engineered transaminase polypeptides for the production of amines, polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to prepare compounds useful in the production of active pharmaceutical agents.

US Patent:

20210277432, Sep 9, 2021

Filed:

May 25, 2021

Appl. No.:

17/330172

Inventors:

- Redwood City CA, US
Steven J. Collier - Concord MA, US
Joly Sukumaran - Singapore, SG
Wan Lin Yeo - Singapore, SG
Oscar Alvizo - Fremont CA, US
Ee Ling Teo - Mauchline East Ayrshire, GB
Robert J. Wilson - San Francisco CA, US
Junye Xu - Singapore, SG

International Classification:

C12P 17/06
C12N 9/10
C12P 7/62
C07K 14/00
C12N 15/52

Abstract:

The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound.

US Patent:

20210269777, Sep 2, 2021

Filed:

May 11, 2021

Appl. No.:

17/317231

Inventors:

- Redwood City CA, US
Helen Hsieh - Singapore, SG
Son Pham - Singapore, SG
Derek Smith - Singapore, SG
Steven J. Collier - Concord MA, US

International Classification:

C12N 9/10
C12P 17/18
C12P 33/00
C12P 15/00
C12P 17/12
C12P 13/00

Abstract:

The present disclosure provides engineered transaminase polypeptides for the production of amines, polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to prepare compounds useful in the production of active pharmaceutical agents.

US Patent:

20210253537, Aug 19, 2021

Filed:

Jun 26, 2019

Appl. No.:

16/973678

Inventors:

- London, GB
Steve POLLINGTON - Billingham, Cleveland, GB
John SWINNEY - Thornaby, GB
Michael David HAMLIN - Devens MA, US
Steven James COLLIER - Devens MA, US

International Classification:

C07D 241/04
C07D 213/20

Abstract:

A process for the production of heterocyclic quaternary ammonium salts or hydroxides is disclosed. The process comprises a continuous hydrogenation step, in which an unsaturated heterocyclic amine is reacted with hydrogen to form a saturated heterocyclic amine; a first continuous N-alkylation step, in which the saturated heterocyclic amine is alkylated to produce an intermediate saturated heterocyclic amine having an increased degree of substitution compared to the saturated heterocyclic amine; and one or more further N-alkylation steps in which the intermediate saturated heterocyclic amine is N-alkylated to the heterocyclic quaternary ammonium salt or hydroxide. A process of producing a saturated heterocyclic amine is also disclosed. The process comprises reacting an unsaturated heterocyclic amine with hydrogen in a vapour phase reaction at a pressure of not more than 70 bar and a temperature in the range of from 150 C. to 350 C. A process of N-alkylating a saturated heterocyclic amine is also disclosed. The process comprises N-alkylating the saturated heterocyclic amine in a vapour phase reaction at a temperature of at least 2 C.

US Patent:

20210071151, Mar 11, 2021

Filed:

Oct 29, 2020

Appl. No.:

17/084405

Inventors:

- Redwood City CA, US
Haibin Chen - Beijing, CN
Anupam Gohel - Bekasi, ID
Steven J. Collier - Concord MA, US
Derek J. Smith - Singapore, SG
Birgit Kosjek - Westfield NJ, US
Jacob Janey - New York NY, US

International Classification:

C12N 9/04
C12P 41/00
C12P 13/00
C12P 13/02

Abstract:

The present disclosure relates to engineered ketoreductase polypeptides for the preparation of hydroxyl substituted carbamate compounds, and polynucleotides, vectors, host cells, and methods of making and using the ketoreductase polypeptides.